S3227 The Risk of Ischemic Cerebrovascular Accident and All-Cause: Mortality Among Patients With Inflammatory Bowel Disease
Notice bibliographique
Résumé
INTRODUCTION: Patients with inflammatory bowel disease (IBD) have an increased risk of venous thrombotic events compared to non-IBD population. The risk of arterial thrombotic events in IBD patients is not well characterized. We aim to identify the risk of ischemic cerebrovascular accidents (CVA) in patients with IBD. METHODS: This is a retrospective cohort study utilizing the Agency for Healthcare Research and Quality’s Healthcare cost and Utilization Project National Inpatient Sample (NIS) for the year 2017. We identified patients with a principal diagnosis of ischemic CVA. The exposure of interest was a secondary diagnosis of either Crohn’s disease (CD) or ulcerative colitis (UC). The primary outcome was prevalence of IBD among patients with ischemic CVA. The secondary outcome was in-hospital all-cause mortality. Univariable linear regression analysis was used to calculate unadjusted odds ratios for the primary and secondary outcomes. Multivariable regression models were built by including all confounders that were significantly associated with the outcome on univariable analysis. Significance was defined as the 2-tailed P value of 0.05. RESULTS: Out of 524,045 patients with a diagnosis of acute ischemic CVA, 2,200 (0.41%) had a concurrent diagnosis of IBD. Of these, 905 (0.17%) patients had UC while 1,315 (0.25%) had CD. The overall incidence of IBD among patients with acute ischemic CVA was 0.41%. After adjusting for potential confounders, patients with acute ischemic CVA were less likely to have IBD [OR 0.61 (95% CI: 0.55–0.67), P < 0.01] compared with those who did not have an ischemic CVA. Patients with acute ischemic CVA had significantly lower adjusted odds of CD [OR 0.61, (95% CI: 0.54–0.70), P < 0.01] as well as UC [OR 0.61, (95% CI: 0.53–0.71), P < 0.01] compared with those who did not have acute ischemic CVA. The in-hospital mortality rate among patients with acute ischemic CVA with and without IBD was 4.09% and 4.01%. On multivariate analysis, there was no significant difference in-hospital mortality among patients with acute ischemic CVA with or without IBD [OR 1.07 (95% CI: 0.65–1.76), P = 0.78]. There was no significant difference in mortality on subgroup analysis of patients with UC (OR 0.91, [95% CI: 0.39–2.09], P = 0.82), and CD (OR 1.17, [95% CI: 0.62–2.19], P = 0.62). CONCLUSION: Both UC and CD are not associated with a disproportionately higher risk of ischemic CVA. Cardiovascular risk assessment in IBD patients is important but should be done in the same way as the general population.Table 1.: Baseline characteristics of study populationTable 2.: Co-morbid conditions of subjects in the studyTable 3.: Primary and secondary outcomes of patients admitted to the hospital with ischemic stroke with and without inflammatory bowel disease
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,003 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,008 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».