Dog Ownership at 3 Months of Age is Associated With Protection Against Food Allergy

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AAP Policy SupplementsSupplements Publish Supplement MultimediaVideo Abstracts Pediatrics On Call Podcast Subscribe Alerts Careers Discover Pediatric Collections on COVID-19 and Racism and Its Effects on Pediatric Health Allergy Dog Ownership at 3 Months of Age is Associated With Protection Against Food Allergy Elinor Simons Pediatrics December 2020, 146 (Supplement 4) S332; DOI: https://doi.org/10.1542/peds.2020-023861S ArticleInfo & MetricsComments Download PDF T Marrs, K Logan, J Craven. Allergy. 2019;74(11):2212–2219PURPOSE OF THE STUDY:A secondary, ad hoc analysis evaluating the association between dog ownership and food allergy development was performed in The Inquiring About Tolerance (EAT) cohort.STUDY POPULATION:The EAT study enrolled 1303 healthy and exclusively breastfed 3-month-old infants from the general population across England and Wales into a randomized trial investigating whether the early dietary introduction of six allergenic solids (egg, peanut, milk, wheat, cod and sesame) reduced the prevalence of food allergy diagnosed from 12–36 months of age.METHODS:At enrollment, pet ownership was reported by questionnaire and infants were examined for atopic dermatitis. Reactions to foods were reported on monthly questionnaires. Sensitization to foods and aeroallergens was elicited by skin prick and serum IgE testing at 3, 12 and 36 months. Food allergy status was determined by double-blind placebo-controlled oral food challenges (DBPC-OFC) between 1 and 3 years.RESULTS:Food allergy was diagnosed in 6.1% (68/1124) of infants with complete data. After adjusting for familial atopic disease, maternal dog/cat sensitization and infant atopic dermatitis, living with dogs was associated with a 90% reduction in the odds of infants developing food allergy (OR 0.10, 95% CI 0.01–0.71, P = .02), with dose responses for owning an increasing number of dogs (OR 0.12, 95% CI 0.02–0.81, P = .03) and closer infant–dog cohabitation (OR 0.11, 95% CI 0.02–0.79, P = .03). There was no relationship between dog ownership and atopic dermatitis (P = .89), interaction between dog ownership and atopic dermatitis on the likelihood of developing food allergy (P = .78), or confounding by randomization group from the original study.CONCLUSIONS:Dog ownership in infancy is inversely associated with food allergy development, after adjusting for infant atopic dermatitis and maternal sensitization.REVIEWER COMMENTS:This study demonstrates an inverse association between dog ownership and food allergy diagnosed by DBPC-OFC in a general-population cohort of breastfed infants. Study strengths include the prospective reporting of dog ownership and of conscious avoidance of dog ownership and the objective measurement of maternal dog sensitization, all of which help to avoid reverse causation bias from infants being at higher risk of food allergy if their parents avoid dogs because of their own allergies. The study is observational and cannot demonstrate causation, although it strongly contributes to the literature evaluating environmental exposure and childhood allergy associations.Copyright © 2020 by the American Academy of Pediatrics PreviousNext Back to top Advertising Disclaimer » In this issue Pediatrics Vol. 146, Issue Supplement 4 1 Dec 2020 Table of ContentsIndex by author View this article with LENS PreviousNext Email Article Thank you for your interest in spreading the word on American Academy of Pediatrics.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. 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Or Sign In to Email Alerts with your Email Address Email * Citation Tools Dog Ownership at 3 Months of Age is Associated With Protection Against Food Allergy Elinor Simons Pediatrics Dec 2020, 146 (Supplement 4) S332; DOI: 10.1542/peds.2020-023861S Citation Manager Formats BibTeXBookendsEasyBibEndNote (tagged)EndNote 8 (xml)MedlarsMendeleyPapersRefWorks TaggedRef ManagerRISZotero Share Dog Ownership at 3 Months of Age is Associated With Protection Against Food Allergy Elinor Simons Pediatrics Dec 2020, 146 (Supplement 4) S332; DOI: 10.1542/peds.2020-023861S Share This Article: Copy Print Download PDF Insight Alerts Table of Contents Jump to section ArticlePURPOSE OF THE STUDY:STUDY POPULATION:METHODS:RESULTS:CONCLUSIONS:REVIEWER COMMENTS:Info & MetricsComments Related ArticlesNo related articles found.Google Scholar Cited By...No citing articles found.Google Scholar More in this TOC SectionAllergy Postnatal Probiotics and Allergic Disease in Very Preterm Infants: Sub-study to the ProPrems Randomized Trial Non–β-Lactam Antibiotic Hypersensitivity Reactions Markers of Microbial Exposure Lower the Incidence of Atopic Dermatitis Show more Allergy Risk Factors and Prevention of Atopy Skin Care and Synbiotics for Prevention of Atopic Dermatitis or Food Allergy in Newborn Infants: A 2 X 2 Factorial, Randomized, Non-Treatment Controlled Trial Early-Life Exposure to Oral Antibiotics and Lung Function Into Early Adulthood Increased Moraxella and Streptococcus Species Abundance After Severe Bronchiolitis Is Associated With Recurrent Wheezing Show more Risk Factors and Prevention of Atopy Similar Articles Journal Info Editorial Board Editorial Policies Overview Licensing Information Authors/Reviewers Author Guidelines Submit My Manuscript Open Access Reviewer Guidelines Librarians Institutional Subscriptions Usage Stats Support Contact Us Subscribe Resources Media Kit About International Access Terms of Use Privacy Statement FAQ AAP.org shopAAP Follow American Academy of Pediatrics on Instagram Visit American Academy of Pediatrics on Facebook Follow American Academy of Pediatrics on Twitter Follow American Academy of Pediatrics on Youtube RSS © 2021 American Academy of Pediatrics

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