P016 Smoking Status Increases Likelihood of Advanced Disease Phenotype in Crohn’s Disease
Notice bibliographique
Résumé
BACKGROUND: The relationship between the smoking status and advanced disease phenotype (stricturing or penetrating) in patients with Crohn's disease (CD) is not well known. This study aims to determine whether smoking status increases the likelihood of advanced disease phenotype in CD patients. METHODS: This was a retrospective study of CD patients seen at McMaster University Medical Centre, in Hamilton, ON, Canada from 2012-2020. Smoking status was dichotomized into two groups, current smokers and ex- or never smokers. Patients were classified as having the primary outcome if their gastroenterologist documented the presence of advanced disease phenotype either during the baseline assessment or during the period of follow-up. Prior knowledge in combination with forward selection was used to develop a multivariate logistic regression model and examine relationships with presence of advanced disease phenotype. The variables considered for the forward selection model included current biologic use, sex, disease duration, disease location, age at diagnosis, and presence of extraintestinal manifestations. RESULTS: A total of 625 CD patients were included in the analysis, of which 186 had stricturing phenotype, 126 had penetrating phenotype and 313 had inflammatory phenotype only. Of the 625 CD patients, 492 had smoking status available – 67 patients were active smokers (13.6%), compared to 85 ex-smokers (17.3%) and 340 non-smokers (69.1%). A univariate regression analysis indicated that the odds ratio (OR) of advanced disease phenotype is 1.80 (95% CI, 1.06 - 3.04) for smokers compared to non/ex-smokers. In the multivariate regression analysis, current biologic use was found to have a significant relationship with advanced phenotype (OR 2.14; 95% CI, 1.47 - 3.11). After adjustment for biologic use, active smokers have 1.93 times higher odds of having advanced phenotype disease (95% CI, 1.11 - 3.35). A sub-analysis of patients with CD penetrating type only displayed smoking (OR 2.01; 95% CI, 1.14 - 3.56) and current biologic use (OR 2.06; 95% CI, 1.33 - 3.18) are significantly associated with penetrating disease. A sub-analysis of patients with CD stricturing type only did not show a significant association with smoking (OR 1.52; 95% CI, 0.88 - 2.62). However, sex [male (OR 1.62; 95% CI, 1.09 - 2.39)] and current biologic use (OR 1.61; 95% CI 1.09 - 2.38) were significantly associated with stricturing disease. CONCLUSION: Current smoking is associated with increased likelihood of advanced disease phenotype in CD patients. Additionally, current biologic use and male sex were found to be have increased odds of advanced phenotype in CD patients. Patients with CD should continue to be advised on the importance of smoking cessation.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,004 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,005 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».