Variation in retinal microvascular parameters is associated with mild cognitive impairment and Alzheimer’s disease
Notice bibliographique
Résumé
Abstract Background Alzheimer's disease (AD) is a neurodegenerative condition characterised by cognitive decline. Mild Cognitive Impairment (MCI) represents a transitional state between ageing normally and all forms of dementia, although those with MCI will not automatically convert to dementia. The retinal and cerebral microvasculature share similar embryological origins and physiological characteristics. Improved imaging technologies enable non‐invasive measurement of retinal microvascular parameters (RMPs). We investigated associations between RMPs and cognitive function in participants with AD and MCI. Method RMPs (arteriolar/venular diameter, fractal dimension, vessel tortuosity) were measured from optic disc centred fundus images and analysed using semi‐automated software. Thirty‐four MCI and thirty‐two AD participants were recruited for the study from the Belfast Health and Social Care Trust memory clinics. Nine MCI and thirteen AD participants were excluded as their retinal images were of insufficient quality for image analysis. Associations were assessed by logistic regression with comparison to an age and sex‐matched control group from the NICOLA study as the reference category. Models were adjusted for potential confounders including smoking, diabetes, hypertension, total cholesterol and Mini Mental State Exam (MMSE) score. P<0.05 was considered significant. Result Data were included for 126 participants with cognitive function measures and sufficient retinal images. Twenty‐five participants had a clinical diagnosis of MCI and nineteen AD. Eighty‐two age and gender‐matched controls with no previous history of cognitive impairment, and MMSE and Montreal Cognitive Assessment scores >26/30 were included. Decreased arteriolar fractal dimension (OR: 0.30; 95%CI: 0.10, 0.91; P=0.03) was significantly associated with AD in all models. Decreased venular fractal dimension and both arteriole and venular diameter were significantly associated with MCI in all models (P <0.05). No further associations were detected (P >0.05). Conclusion Our findings identified variation in RMPs in association with MCI and AD in an older population. Additionally, previous studies have reported associations between reduced fractal dimension with MCI and AD. We were able to replicate these associations in unadjusted analyses, and following adjustment for confounders. These non‐invasive retinal measures may help identify mechanistic pathways of microvascular complications early in the disease process in individuals at increased risk of MCI and AD.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».