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Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019

2020· review· en· 11 066 citations· W3113178943 sur OpenAlex· 10.1016/j.jacc.2020.11.010

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Résumé

Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disease (GBD) Study 2019. GBD, an ongoing multinational collaboration to provide comparable and consistent estimates of population health over time, used all available population-level data sources on incidence, prevalence, case fatality, mortality, and health risks to produce estimates for 204 countries and territories from 1990 to 2019. Prevalent cases of total CVD nearly doubled from 271 million (95% uncertainty interval [UI]: 257 to 285 million) in 1990 to 523 million (95% UI: 497 to 550 million) in 2019, and the number of CVD deaths steadily increased from 12.1 million (95% UI:11.4 to 12.6 million) in 1990, reaching 18.6 million (95% UI: 17.1 to 19.7 million) in 2019. The global trends for disability-adjusted life years (DALYs) and years of life lost also increased significantly, and years lived with disability doubled from 17.7 million (95% UI: 12.9 to 22.5 million) to 34.4 million (95% UI:24.9 to 43.6 million) over that period. The total number of DALYs due to IHD has risen steadily since 1990, reaching 182 million (95% UI: 170 to 194 million) DALYs, 9.14 million (95% UI: 8.40 to 9.74 million) deaths in the year 2019, and 197 million (95% UI: 178 to 220 million) prevalent cases of IHD in 2019. The total number of DALYs due to stroke has risen steadily since 1990, reaching 143 million (95% UI: 133 to 153 million) DALYs, 6.55 million (95% UI: 6.00 to 7.02 million) deaths in the year 2019, and 101 million (95% UI: 93.2 to 111 million) prevalent cases of stroke in 2019. Cardiovascular diseases remain the leading cause of disease burden in the world. CVD burden continues its decades-long rise for almost all countries outside high-income countries, and alarmingly, the age-standardized rate of CVD has begun to rise in some locations where it was previously declining in high-income countries. There is an urgent need to focus on implementing existing cost-effective policies and interventions if the world is to meet the targets for Sustainable Development Goal 3 and achieve a 30% reduction in premature mortality due to noncommunicable diseases.

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La notice

Revue
Journal of the American College of Cardiology
Thématique
Cardiovascular Health and Risk Factors
Domaine
Medicine
Établissements canadiens
University of British Columbia
Organismes subventionnaires
National Institute of Neurological Disorders and StrokeNational Heart, Lung, and Blood InstituteMedical Research CouncilRegeneron PharmaceuticalsMylanNational Institutes of HealthEsperion TherapeuticsFundação de Amparo à Pesquisa do Estado de Minas GeraisNational Human Genome Research InstituteDepartment for International DevelopmentDaiichi-SankyoVirginia Marine Resources CommissionConselho Nacional de Desenvolvimento Científico e TecnológicoFondazione CariploAmgenNational Research FoundationAmryt PharmaIonis PharmaceuticalsDepartment for International Development, UK GovernmentNational Institute of Diabetes and Digestive and Kidney DiseasesSanofiNational Kidney FoundationKowa CompanyEli Lilly and CompanyAstraZenecaBill and Melinda Gates FoundationAmerican Heart Association
Mots-clés
MedicineBurden of diseasePopulationDisease burdenYears of potential life lostDemographyEnvironmental healthIncidence (geometry)Disability-adjusted life yearGlobal healthCause of deathCase fatality rateLife expectancyPublic healthDisease
Résumé présent dans OpenAlex
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