Abstract PS12-28: Phase 1b study evaluating a triplet combination of ipatasertib (IPAT), atezolizumab, and a taxane as first-line therapy for locally advanced/metastatic triple-negative breast cancer (TNBC)
Notice bibliographique
Résumé
Abstract Background: The combination of immune checkpoint modulators with chemotherapy improves efficacy compared with chemotherapy alone in PD-L1+ advanced TNBC (IMpassion130; KEYNOTE-355). The addition of IPAT to paclitaxel (PAC) improved efficacy in a phase 2 trial in advanced TNBC (LOTUS). Preliminary overall response rate (ORR) data from a multicenter phase 1b study (NCT03800836) evaluating a triplet combination of IPAT, atezolizumab, and taxane chemotherapy showed promising anti-tumor activity in a similar patient population, irrespective of PD-L1 status [Schmid, AACR 2019]. Here, we report follow-up results including progression-free survival (PFS) from this study. Patients and Methods: Eligible patients had measurable unresectable locally advanced/metastatic TNBC, ECOG performance status 0/1, and had received no prior systemic therapy for advanced disease (prior [neo]adjuvant chemotherapy and/or radiation permitted if all chemotherapy was completed ≥12 months before first dose). Patients with brain metastases were excluded. Patients received oral IPAT 400 mg/day on days 1–21 and IV atezolizumab 840 mg on days 1 & 15 in combination with PAC 80 mg/m2 (Arm A) or nab-PAC 100 mg/m2 (Arm B) on days 1, 8, & 15. Cycles were repeated every 28 days until loss of clinical benefit, unacceptable toxicity, or consent withdrawal. Arms C and D evaluated sequential regimens comprising a doublet induction therapy with the third agent added on day 15 (Arm C: IPAT + PAC, then + atezolizumab; Arm D: atezolizumab + PAC, then + IPAT). Tumors were assessed every 8 weeks. Key endpoints were confirmed ORR (per RECIST v1.1), duration of response (DoR), PFS, and safety. Results: At the data cut-off (26 Jul 2020), results were available from 114 patients (Arm A n=70, Arm B n=20, Arm C n=12, Arm D n=12). Median duration of follow-up was 11.1 months. Efficacy results are summarized in the table. Safety of the combination appeared to be consistent with the known safety profile of the individual drugs. Grade ≥3 adverse events (AEs) occurred in 55% of patients (including rash [13%], diarrhea [12%], and neutropenia [10%]) and serious AEs in 34%. AEs led to discontinuation of IPAT in 6% of patients and atezolizumab in 4%. No new safety signals were identified. Conclusions: Updated results demonstrate a lower ORR than in the preliminary report of the first 26 patients. Subgroup analyses according to PD-L1 or PIK3CA/AKT1/PTEN alteration status or taxane backbone show no consistent trend across endpoints, although small sample sizes limit interpretation. Further biomarker analyses focusing on subgroups and biology may identify subsets of patients deriving a benefit. PopulationConfirmed ORR, n (%) [95% CI]Median DoR, months (95% CI)aMedian PFS, months (95% CI)All patients (n=114)61 (54) [44–63]7.3 (5.6–7.8)7.2 (5.5–7.4)PD-L1 statusbPositive (n=51)32 (63) [48–76]7.4 (5.0–12.9)7.3 (5.4–7.4)Negative (n=45)20 (44) [30–60]5.6 (3.7–7.4)7.2 (5.4–9.1)Unknown (n=18)9 (50) [26–74]11.1 (5.8–NE)6.3 (4.9–11.0)Arm (taxane backbone)A (PAC) (n=70)36 (51) [39–64]7.4 (5.6–12.9)7.2 (5.3–7.4)B (nab-PAC) (n=20)13 (65) [41–85]7.3 (3.9–7.4)6.6 (3.4–9.0)C+D (PAC) (n=12+12)12 (50) [29–71]6.8 (3.9–14.7)7.5 (5.5–11.3)PIK3CA/AKT1/PTEN statuscAltered (n=36)d19 (53) [35–70]6.8 (3.9–7.6)7.4 (5.5–9.1)Non-altered (n=45)28 (62) [47–76]7.3 (5.5–9.4)6.6 (5.2–9.0)Unknown (n=33)14 (42) [25–61]10.2 (5.8–NE)6.0 (5.1–9.1)aIn responding patients. bAssessed by VENTANA SP142 immunohistochemistry assay (Ventana Medical Systems, Tucson, AZ, USA); PD-L1+ defined as immune cell expression in ≥1% of the tumor area. cAssessed using FoundationOne CDx (Foundation Medicine, Cambridge, MA, USA). dPIK3CA/AKT mutation (n=12) or PTEN alteration (n=24). CI = confidence interval; nab = nanoparticle albumin-bound; NE = not estimable. Citation Format: Peter Schmid, Peter Savas, Enrique Espinosa, Valentina Boni, Antoine Italiano, Shane White, Karen Cheng, Lisa Lam, Lidia Robert, Victor Laliman, Kalpit Shah, Marie-Paule Sablin. Phase 1b study evaluating a triplet combination of ipatasertib (IPAT), atezolizumab, and a taxane as first-line therapy for locally advanced/metastatic triple-negative breast cancer (TNBC) [abstract]. In: Proceedings of the 2020 San Antonio Breast Cancer Virtual Symposium; 2020 Dec 8-11; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2021;81(4 Suppl):Abstract nr PS12-28.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».