Notice bibliographique
Résumé
We are now well into 2021, and the COVID-19 vaccination roll-out is in progress, but we are still trying to handle a global pandemic. I hope people take heart from this issue that looks back 100 years, and to the future, to celebrate the discovery of insulin and how this paved the way for saving millions of lives globally. Diabetes is still a disease that has no cure but our knowledge of its biochemistry means it is now manageable and this has transformed the lives of those with the disease within an extremely short period of time.I want to speak about this discovery at the start of this special themed issue. The first use of insulin for treatment of type 1 diabetes in humans was in January 1922, less than 12 months after it had been first successfully extracted by surgeon Sir Frederick Banting and physiologist Charles Best in the labs of Professor John MacLeod at the University of Toronto. James Collip, a Canadian biochemist, had joined the team in Toronto and was able to help concentrate and extract a purer form of insulin from cattle which could then be used in humans.The first treatment involved two injections of insulin that were given to Leonard Thompson, a 14-year-old boy and, for the first time, they were able to lower high blood sugar and he recovered. As is the case with most scientific discoveries, it involved knowledge and input from multiple people to enable people around the world to be treated by insulin. The Nobel Prize was awarded to Banting and Macleod in 1923 with Banting then splitting half of his prize money with Best and Macleod splitting his half with Collip.We are still learning about diabetes today, and with higher numbers of people being diagnosed with type 2 diabetes, it is important to continue the search for a cure for the disease.I am humbled that this is the theme for my first issue of The Biochemist and I want to thank the previous editor Chris Willmott for confirming this as a theme and for his work with The Biochemist over the past few years. The magazine has introduced new features and now has a more easily accessible online presence. I hope that I can maintain the high standard that has been set, and continue to grow the publication.The role of molecular bioscience in society has never been in more focus than it has been over the past 12 months and I want to ensure that The Biochemist continues to highlight the importance of that work.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,003 | 0,024 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,001 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,002 | 0,001 |
| Études des sciences et des technologies | 0,002 | 0,001 |
| Communication savante | 0,008 | 0,005 |
| Science ouverte | 0,002 | 0,003 |
| Intégrité de la recherche | 0,006 | 0,011 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,093 | 0,051 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».