PD50-02 PROSTATE SPECIFIC ANTIGEN DYNAMICS AND PROSTATE CANCER RISK: A POPULATION-BASED STUDY
Notice bibliographique
Résumé
INTRODUCTION AND OBJECTIVE: While there is disagreement between professional medical organizations about which patients should undergo Prostate Specific Antigen (PSA) screening, there are no guidelines that recommend PSA screening more often than annually.Despite this, there are patients who have their PSA tested more frequently, which we have termed "Prosteria".We aimed to characterize patient demographic and temporal trends of frequent PSA testing.METHODS: Adult men with at least three PSA tests and two or more years of continuous insurance enrollment in the Optum Deidentified ClinformaticsÒ Data Mart were included in this study.Men were censored at the end of their insurance enrollment or 30 days prior to a diagnosis of prostate cancer, prostatitis, or UTI.PSA tests were excluded if they occurred within 30 days of a prior PSA test."High frequency PSA testing" was defined as an average of one or more PSA tests every 9 months.Multivariable logistic regression evaluated associations between demographic features and PSA testing frequency.RESULTS: 9,547,876 PSA tests obtained between January 2003 and June 2019 on 1,996,472 men were included.While 55% of men were tested less than annually, 19% of men underwent high frequency testing.The distribution of time between PSA tests was notable for spikes around 90, 180, and 365 days.Patients were less likely to undergo high frequency testing if they were White (OR: 0.73, 95% CI: [0.72, 0.73]), educated (OR: 0.91, 95% CI: [0.91, 0.92]), and younger (OR: 0.98 per year, 95% CI: [0.97-0.98]).However, a U-shaped distribution was observed with men aged 55-65 being less likely to undergo high frequency testing than younger or older men.Of men with PSA levels available, men with high frequency testing had higher average PSA values (1.99 (SD: 1.94) vs 1.31 (SD: 1.30); p < 0.001).Over the study period, the proportion of patients getting high frequency testing increased at a rate of 1.17% per year (figure).CONCLUSIONS: In this large cohort study, high-frequency PSA testing was common, increasing over time, and significantly associated with demographic characteristics.Future work will investigate variations between ordering providers based on geographic region and specialty, as well as the impact of screening frequency on rates of prostate biopsy, cancer detection and treatment.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,001 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,001 | 0,003 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».