<p>Ethics of conducting the study "Oral 24% sucrose associated with nonnutritive sucking for pain control in healthy term newborns receiving venipuncture beyond the first week of life" [Letter]</p>
Notice bibliographique
Résumé
We refer to the pilot study by De Bernardo et al, 1 in which 66 healthy infants were randomized to 24% sucrose or 10% glucose during venipuncture.Findings were 24% sucrose statistically significantly reduced pain compared to 10% glucose.This is not surprising as the efficacy of sweet tasting solutions in reducing pain in newborn infants has been known since the early 2000s, 2 and less concentrated solutions, including the 10% glucose used in this study had already been shown to be ineffective.Therefore, this trial, which studied an already known effective intervention compared to an already known ineffective intervention, does not comply with the principle of equipoise.2,3 Clinical research trials require equipoise, defined as "a state of genuine uncertainty on the part of the clinical investigator regarding the comparative therapeutic merits of each arm in a trial".3 This requires that the investigator is fully aware of the current knowledge regarding benefits of intervention and control arms and existing knowledge gaps before planning a trial.Unfortunately, it is evident the authors were not aware of the knowledge concerning analgesic effects of sweet solutions before they commenced their study.The authors state "The study was conducted in accordance with the Declaration of Helsinki".However, this implies that: "Medical research involving human subjects must conform to generally accepted scientific principles, be based on a thorough knowledge of the scientific literature…".4 As stated earlier, this had obviously not occurred as evidenced by the omission in the reference list of key systematic reviews on the topic.Another concern with this paper relates to parental informed consent.The authors stated that informed consent from the families was obtained.However, were parents truly informed about the study?Were they informed of the fact that there was already abundant evidence to support 25% sucrose during venipuncture?Were they informed about analgesic effects of other strategies they could use during their infants' venipuncture, such as breastfeeding? 5 Engaging with and involving parents of hospitalized infants from the beginning of the study may have resulted in more relevant research being conducted.In conclusion, extensive research conducted over the past two decades has clearly demonstrated that sweet solutions, if sufficiently sweet, reduce acute
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,009 | 0,033 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,001 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,002 | 0,003 |
| Communication savante | 0,002 | 0,001 |
| Science ouverte | 0,002 | 0,001 |
| Intégrité de la recherche | 0,015 | 0,015 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,026 | 0,013 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».