Carotid Chemoreflex Regulation of Post‐Exercise Cardiac Autonomic Control in Healthy Humans: Influence of Exercise Intensity
Notice bibliographique
Résumé
The recovery of cardiac autonomic control from exercise has two phases. The fast phase lasts about 60 s after exercise, and is largely dependent on the cardiac vagal reactivation. The slow phase is 300 s in duration, and is dependent on both the cardiac vagal reactivation and sympathetic withdrawal. Indexes of post‐exercise cardiac autonomic control are widely used in the clinical practice to predict morbidity and mortality. However, the mechanisms that regulate the post‐exercise cardiac autonomic control remain unclear. The carotid chemoreflex regulates cardiac autonomic control at rest, and carotid chemoreceptors are stimulated by humoral and neural signals related to exercise. As the extent of the humoral and neural responses are dependent upon exercise intensity, we hypothesized the carotid chemoreflex could regulate post‐exercise cardiac autonomic control in an exercise‐intensity‐dependent manner. Thirteen healthy humans performed ramp incremental exercise up to either moderate‐intensity (MI; i.e., ventilatory threshold) or high‐intensity exercise (HI; i.e., 90% peak workload). Both MI and HI exercise were followed by 5 min of active recovery (i.e., unloaded cycling) while breathing, in random order, normoxia (21% of O 2 , control), hyperoxia (100% of O 2, carotid chemoreflex inhibition) or hypoxia (12% of O 2, carotid chemoreflex stimulation). Gas administration started 10 s before the onset of recovery from exercise. The fast phase of cardiac autonomic control recovery from exercise was assessed by the heart rate (HR) reduction at 60 s post‐exercise (HRR60s). The slow phase was assessed by the time constant of exponential HR decay (HRRτ) over 300 s and the HR reduction at 300 s post‐exercise (HRR300s). Fast and slow phases were assessed by the square root of mean squared differences of successive R‐R intervals of 30‐s data segments (RMSSD 30s ). As compared to normoxia, hyperoxia did not change HRR60s at either exercise intensities. Hypoxia did not change HRR60s at MI, but decreased HRR60s at HI (normoxia: 29 ± 8 vs hypoxia: 17 ± 9 bpm; P < 0.01). Hyperoxia and hypoxia did not change HRRτ. Hyperoxia did not affect HRR300s, but hypoxia decreased HRR300s similarly at both exercise intensities (MI: normoxia = 32 ± 14 vs hypoxia = 26 ± 17 bpm; HI: normoxia = 55 ± 7 vs hypoxia = 48 ± 11 bpm; post hoc for gas main effect: P = 0.03). Finally, regardless of the time, hyperoxia increased RMSSD 30s (MI: normoxia = 15 ± 7 vs hyperoxia = 19 ± 10 ms; HI: normoxia = 5 ± 3 vs hyperoxia = 6 ± 3 ms, post hoc for gas main effect: P < 0.01), whereas hypoxia decreased RMSSD 30s (MI: hypoxia = 13 ± 9 ms vs normoxia; HI: hypoxia = 4 ± 2 vs normoxia, post hoc for gas main effect: P < 0.01) at both exercise intensities. In conclusion, the carotid chemoreflex regulates both the fast and slow phases of post‐exercise cardiac autonomic control in healthy humans; however, only the fast phase regulation is dependent on the exercise intensity. These results suggest that sensitization of the carotid chemoreflex with exercise plays an important role for the post‐exercise cardiac vagal reactivation. Support or Funding Information FAPESP 2015/22198‐2; 2018/03501‐4 This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».