Sympathetic Changes through the Menstrual Cycle are Absent in Women with Diabetes
Notice bibliographique
Résumé
Background Glycemic variability (GV) can contribute to autonomic dysfunction in diabetes (Jaiswal et al. 2014), and autonomic dysfunction can be apparent as early as childhood (Metwalley et al. 2018). In women with diabetes, GV can differ throughout the menstrual cycle where hyperglycemia and decreased insulin sensitivity are often present in the luteal phase (Brown et al. 2015). Therefore, we investigated the role of the menstrual cycle in autonomic control in women with diabetes. Methods Women with diabetes (n=7; age 23.6 ± 1.0years; BMI 24.4 ± 1.1kg/m 2 ) were tested in the early follicular (EF; day 2–5) and mid‐luteal (ML; day 18–24) phases of the menstrual cycle. Blood glucose was 8.6 ± 1.1mmol/L in the EF phase and 8.1 ± 0.7mmol/L in the ML phase (P=0.71). Trials included resting heart rate variability (HRV), paced deep breathing, Valsalva, and 10 minutes of 70‐degree upright tilt. Heart rate (HR), stroke volume index (SVi), and mean arterial pressure (MAP) were measured. Frequency domain analysis of HRV was conducted on 5 minutes of resting ECG (low frequency power (LF) and high frequency power (HF)). Results The expiration to inspiration HR ratio during paced deep breathing (EF: 1.40 ± 0.06, ML: 1.43 ± 0.05, P=0.39) and the Valsalva HR ratio (EF: 2.29 ± 0.16, ML: 2.16 ± 0.13, P=0.48) were similar between the phases. During the Valsalva maneuver, the increase in MAP from Phase II minimum to the end of Phase II was similar between phases (EF: +18.6 ± 3.8mmHg, ML: +18.4 ± 1.5mmHg, P=0.64). Upright tilt resulted in higher HR (P=0.005) and lower SVi (P=0.011) with no interaction effects between tilt and menstrual phase (P≥0.64). The maximum HR response to tilt was similar between the phases (EF: 101.2 ± 5.7bpm, ML: 99.5 ± 5.9bpm, P=0.69). There were no differences between phases in resting heart rate variability (LF(nu): EF: 37.5 ± 6.0, ML: 40.2 ± 6.8, P=0.68; HF(nu): EF: 45.0 ± 8.3 ML: 58.0 ± 6.3, P=0.66). Conclusion Abidi et al. (2017) found a strong tendency for a greater MAP response to Valsalva in the ML phase compared to the EF phase in healthy women. They also found higher heart rate and cardiac output in the ML phase compared to the EF phase throughout 10min of standing supporting greater sympathetic output in the ML phase. Further, in healthy participants, Brar et al. (2015) and Carter et al. (2013) found higher LF control of HR and higher resting muscle sympathetic nerve activity in the ML phase, respectively. Therefore, we suggest that the expected increase of sympathetic activity in the ML phase is absent in women with diabetes. Support or Funding Information Faculty of Health, York University Canadian Foundation for Innovation ‐ Infrastructure Operating Fund Natural Sciences and Engineering Research Council of Canada This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».