An MRI Investigating of the Lower Limb Musculature in Patients with Chronic Inflammatory Demyelinating Polyneuropathy
Notice bibliographique
Résumé
Introduction Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease characterized by peripheral nerve demyelination. Patients present with sensory and motor deficits, including symmetrical diffused muscle weakness especially in distal muscles. Studies have focused mainly on the neuropathic aspects of CIDP and its involvement in paresis, showing lesions in various nerve plexes including the lumbar nerve roots. Weakness in patients with CIDP has been reported predominantly in the distal musculature. However, changes in muscle quality and quantity have not been explored systematically throughout the lower limb. Thus, the purpose of this study was to use magnetic resonance imaging (MRI) to compare anatomical differences in the quadriceps femoris and triceps surae muscle complexes in a group of patients with CIDP and control subjects. Methods To date, five patients with CIDP (3 males, 2 females) and six healthy controls (4 males, 2 females) and matched on age (45 to 68 years) have been investigated. On separate days, MRI (T1) of the lower limb musculature was acquired via serial axial plane scans in a 3.0‐Tesla magnet with a 3D FLASH sequence: (0.9mm slice thickness with slice separation of 1mm ranging from 280 to 400 slices). All MRI scans were analyzed using OsiriX imaging processing software. On a single thigh slice (two‐thirds distance proximal to distal) and leg slice (one‐third distance proximal to distal) total muscle area was computed for the quadriceps femoris (rectus femoris, vastus lateralis, vastus intermedius, vastus medialis), and the triceps surae (soleus, lateral and medial gastrocnemii) groups, respectively. Contractile muscle area (fat and connective tissue removed) for each muscle group was determined using a pixel threshold intensity algorithm. Percentage of fat infiltration was computed by subtracting contractile muscle area from total muscle area. Results Patients with CIDP had ~24% less total anatomical cross‐sectional area (ACSA) in both quadriceps femoris and the triceps surae compared to controls. Patients with CIDP, however had ~35% less contractile muscle tissue in the quadriceps femoris whereas the triceps surae were ~51% lower in contractile tissue, compared with controls. The ACSA of the triceps surae of CIDP patients consisted of ~40% fat whereas the quadriceps femoris ACSA had ~16% fat infiltration. Furthermore, the control group's ACSA consisted of ~9% and 5% fat, respectively in the triceps surae and quadriceps. Conclusion Patients with CIDP have less total thigh ACSA with increased intramuscular fat infiltration compared with controls indicative of lower muscle quality in CIDP. Fatty infiltration in the CIDP group are greater in the anterior thigh compared to posterior leg. This indicates that in addition to lower muscle quantity and quality in CIDP, distal musculature seems to be affected to a greater degree by the nerve impairments noted in CIDP. Support or Funding Information Supported by NSERC This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».