Investigating the Triceps Surae in Chronic Inflammatory Demyelinating Polyneuropathy Patients using Magnetic Resonance Imaging
Notice bibliographique
Résumé
Introduction Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired autoimmune disease, primarily characterized by peripheral nerve demyelination. Patients present with sensory and motor deficits, including but not limited to symmetrical diffused muscle weakness. Studies to date have mainly focused on the neuropathic aspects of CIDP and its involvement in paresis. Impairments in skeletal muscle quality and quantity may be a consequence of motor nerve deficits, but these aspects have not been investigated comprehensively. Thus, the purpose of this study was to use magnetic resonance imaging (MRI) to explore anatomical and functional differences in the triceps surae muscle complex in a group with CIDP with a healthy control group. Methods To date, five patients with CIDP and six healthy control subjects were matched on anthropomorphic characteristics. Both groups underwent isometric plantar flexion strength measurements on a custom dynamometer. On separate days, MRI (T1 and T2) of the leg musculature was acquired via serial axial plane scans in a 3.0‐Tesla magnet. All MRI scans were analyzed using OsiriX imaging processing software. Total muscle volume was computed using the T1 weighted anatomical images with a 3D FLASH sequence: (0.9mm slice thickness with slice separation of 1mm ranging from 280 to 400 slices). T2 weighted relaxation times were determined from images with a spin‐echo sequence (5.0mm slice thickness; 16 echoes between 13.2–211.2ms). Both total volume (T1) and relaxation times (T2) were calculated separately for the three components of the triceps surae: soleus, medial gastrocnemius (MG), and lateral gastrocnemius (LG). Results CIDP patients had ~34% less plantar flexion strength compared with controls. CIDP patients had ~14%, ~28% and ~38% smaller muscle total volumes in the soleus, MG and LG, respectively, compared to controls. When strength was normalized to total triceps surae volume it was ~26% lower in CIDP. T2 relaxation times were significantly longer in CIDP with the soleus, MG and LG showing ~37%, ~31% and ~29% longer relaxation times, respectively. Conclusion CIDP patients were significantly weaker compared to control subjects. When strength was normalized to total triceps surae volume the difference remained indicating CIDP patients have lower intrinsic muscle contractile quality. This is further reinforced by the significantly longer T2 relaxation times, which likely reflects an increase in intramuscular fat infiltration in the CIDP group. The results indicate that muscle quantity and quality are affected by alterations in axonal function due to CIDP. Support or Funding Information Supported by NSERC This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».