Abstract 206: CIViC knowledgebase adapts to field experts and community input
Notice bibliographique
Résumé
Abstract CIViC (civicdb.org) is an open access, expertly moderated knowledgebase for crowdsourcing Clinical Interpretations of Variants in Cancer. Stakeholders globally-including those in government, academia, industry and medicine-use CIViC to find and curate actionable interpretations of genomic variants in their therapeutic, prognostic, predisposing, diagnostic and functional contexts. Through engagement with curators and leaders in the field, CIViC has implemented several features including Assertions, Organizations and expanded help documentation. The foundational unit of CIViC is the Evidence Item, which describes the clinical relevance of a specific variant curated from a single published source within peer-reviewed literature or ASCO abstract. Assertions aggregate Evidence Items for a given variant-disease or variant-disease-therapy combination. In response to the 2017 AMP-ASCO-CAP guidelines and collaborations with ClinGen, Assertions were modified to integrate ACMG variant pathogenicity classifications, AMP-ASCO-CAP tier designations and associations with NCCN guidelines and FDA approvals to provide a ‘state of the field' interpretation. At present, 12 Assertions spanning eight variants have been submitted by CIViC to ClinVar with one-star submitter status (Submitter ID: 506594), and CIViC has been cited as supporting information in two variants. Assertions exemplify CIViC's responsiveness to new field guidelines, expert collaborators' recommendations and its contributions to other resources. To enhance community involvement, CIViC created Organization-attributed actions. Each action performed by a curator is tagged with their Organization. Curators may switch between Organizations if they belong to more than one. Currently, nine Organizations are recognized in CIViC, the largest being ClinGen with 79 members, 4 sub-organizations and over 24,000 actions. Organizations enable groups to prominently display and track their submissions, activity, and users. CIViC's wide adoption has necessitated the development of robust educational material. CIViC has created nine YouTube videos, one of which is linked by the NIH ITCR homepage. CIViC has migrated help documents to a stand alone site (civic.readthedocs.io) and has made over 60 page modifications since 2019. Help documentation expansion was fueled by user feedback via the CIViC interface, collaborator meetings and in-person events (Curation Jamborees). Improved documentation allows CIViC to grow at scale, unhindered by the need for direct training. CIViC's rapid adaptation to the needs of the community is derived from its open access nature, commitment to data provenance, active connection with users, and abundance of educational material. CIViC rapidly integrates the guidelines, regulatory standards and community recommendations in a freely accessible resource that is flexible enough to evolve with the dynamic field of cancer genomics. Citation Format: Lana M. Sheta, Arpad M. Danos, Jason Saliba, Kilannin Krysiak, Alex H. Wagner, Erica K. Barnell, Susanna Kiwala, Joshua F. McMichael, Adam Coffman, Shahil Pema, Lynzey Kujan, Kelsy C. Cotto, Cody Ramirez, Zachary L. Skidmore, Cameron J. Grisdale, Shruti Rao, Subha Madhaven, Malachi Griffith, Obi L. Griffith. CIViC knowledgebase adapts to field experts and community input [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 206.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,020 | 0,087 |
| Méta-épidémiologie (sens strict) | 0,002 | 0,001 |
| Méta-épidémiologie (sens large) | 0,001 | 0,002 |
| Bibliométrie | 0,010 | 0,006 |
| Études des sciences et des technologies | 0,003 | 0,001 |
| Communication savante | 0,008 | 0,009 |
| Science ouverte | 0,005 | 0,013 |
| Intégrité de la recherche | 0,004 | 0,003 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,102 | 0,057 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».