PD51-12 WHOLE-PELVIS COMPARED TO BLADDER-ONLY RADIATION THERAPY PROLONGS OVERALL SURVIVAL IN MUSCLE-INVASIVE BLADDER CANCER PATIENTS: RESULTS FROM A CANADIAN MULTI-CENTER COLLABORATIVE STUDY
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Résumé
You have accessJournal of UrologyBladder Cancer: Invasive III (PD51)1 Sep 2021PD51-12 WHOLE-PELVIS COMPARED TO BLADDER-ONLY RADIATION THERAPY PROLONGS OVERALL SURVIVAL IN MUSCLE-INVASIVE BLADDER CANCER PATIENTS: RESULTS FROM A CANADIAN MULTI-CENTER COLLABORATIVE STUDY Ronald Kool, Gautier Marcq, Ionut Busca, Hamidreza Abdi, Rodney Breau, Mark Dawidek, Peter Black, Gagan Fervaha, Robert Siemens, Nimira Alimohamed, Claudio Jeldres, Michael Uy, Bobby Shayegan, Jonathan Izawa, Michael Kim, Girish Kulkarni, and Wassim Kassouf Ronald KoolRonald Kool More articles by this author , Gautier MarcqGautier Marcq More articles by this author , Ionut BuscaIonut Busca More articles by this author , Hamidreza AbdiHamidreza Abdi More articles by this author , Rodney BreauRodney Breau More articles by this author , Mark DawidekMark Dawidek More articles by this author , Peter BlackPeter Black More articles by this author , Gagan FervahaGagan Fervaha More articles by this author , Robert SiemensRobert Siemens More articles by this author , Nimira AlimohamedNimira Alimohamed More articles by this author , Claudio JeldresClaudio Jeldres More articles by this author , Michael UyMichael Uy More articles by this author , Bobby ShayeganBobby Shayegan More articles by this author , Jonathan IzawaJonathan Izawa More articles by this author , Michael KimMichael Kim More articles by this author , Girish KulkarniGirish Kulkarni More articles by this author , and Wassim KassoufWassim Kassouf More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002078.12AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Previous randomized data failed to show a clear oncological benefit of whole-pelvis (WP-RT) compared to bladder-only radiation (BO-RT) in highly selected patients with non-metastatic muscle-invasive bladder cancer (MIBC) undergoing chemoradiation. Our objective was to evaluate the impact of WP-RT vs. BO-RT on overall survival (OS) in an unselect population of MIBC patients treated with RT-based bladder preserving therapy. METHODS: We conducted a collaborative Canadian study of 943 non-metastatic MIBC patients (cT2-4b, cN0-3, M0) who underwent bladder-preserving RT-based therapy with curative intent (≥40Gy) at 10 academic centers across Canada. Baseline clinico-pathological characteristics and follow-up data were collected. Kaplan-Meier survival estimates were performed. A multivariable Cox regression model was used to explore independent predictors of OS. RESULTS: Median age was 77 years [IQR 68-82], 694 (74%) patients were males. A total of 719 patients (76%) were cT2, 220 (24%) cT3-4b, 90 (10%) were N+, and 188 (20%) had concomitant CIS. WP-RT was delivered to 552 (52%) patients. At 3 months post RT, 71% had a complete response (CR). Median follow-up was 54 months (95% CI 49-58) and 439 patients (46.6%) died. Median time to death was 52 months (95% CI 44-66). On multivariable analysis, WP-RT was associated with prolonged OS (HR 0.61, p<0.001), independently of age (HR 1.03, p=0.004), ECOG (HR 1.80, p<0.001), high cT stage (HR 1.39, p=0.035), presence of hydronephrosis (HR 1.59, p=0.007) and CR (HR 0.55, p<0.001). CONCLUSIONS: WP-RT is associated with improved OS in MIBC patients undergoing bladder-preserving therapy. Prospective trials are needed to validate these findings, as RT-based therapy is increasingly utilized in patients with higher risk MIBC. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e910-e910 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ronald Kool More articles by this author Gautier Marcq More articles by this author Ionut Busca More articles by this author Hamidreza Abdi More articles by this author Rodney Breau More articles by this author Mark Dawidek More articles by this author Peter Black More articles by this author Gagan Fervaha More articles by this author Robert Siemens More articles by this author Nimira Alimohamed More articles by this author Claudio Jeldres More articles by this author Michael Uy More articles by this author Bobby Shayegan More articles by this author Jonathan Izawa More articles by this author Michael Kim More articles by this author Girish Kulkarni More articles by this author Wassim Kassouf More articles by this author Expand All Advertisement Loading ...
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,004 | 0,006 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,003 |
| Bibliométrie | 0,001 | 0,003 |
| Études des sciences et des technologies | 0,002 | 0,001 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,002 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».