The effects of exercise training on antitumor efficacy of doxorubicin in MDA-MB-231 breast cancer xenografts
Notice bibliographique
Résumé
1092 In recent years a growing number of reports have examined the role of exercise as a supportive intervention for cancer patients during adjuvant chemotherapy. All studies to date have focused exclusively on the ability of exercise to improve physical functioning or help patients cope with side-effects of treatment in order to improve quality of life. However, a critical and previously unexplored question is whether exercise training influences the efficacy of chemotherapy. To address this question, MDA-MB-231 breast carcinoma cells (5 X 106) were subcutaneously injected into the right flank of female athymic mice (age 3-4 weeks). Following tumor establishment (14 days), mice were stratified by tumor volume and randomly assigned to one of four groups (n=21 per group): (i) control (CO), (ii) exercise only (EX), (iii) chemotherapy only (CT), or (iv) exercise + chemotherapy (EX+CT). Doxorubicin was administered through weekly intravenous lateral tail vein injections at 4mg/kg for 8 weeks. Exercise groups performed progressive treadmill running up to 18m/min at 0% grade for 45mins, 5 days/wk for 8 weeks. Mice were sacrificed when tumor volume reached 1100mm3 as required by institutional guidelines or 48 hours following the final exercise training session. Tumor volume was measured twice weekly. The primary endpoint was tumor growth delay, calculated as the median number of days for tumor burden to reach 1100mm3. Survival times were compared using the log-rank test and all tests were two-sided. Median tumor growth delay was significantly longer in the CT and EX+CT groups compared with the CO (42 days vs. 25 days, RR 0.38, p=0.0084; 36 days vs. 25 days, RR 0.46, p=0.029, respectively) and EX groups (42 days vs. 25 days, RR 0.45, p=0.029; 36 days vs. 25 days, RR 0.54, p=0.080, respectively). There was no significant difference between CT and EX+CT groups (42 days vs. 36 days, RR 1.44, p=0.33). At 56 days, Kaplan-Meier estimates indicated a 35% (95% CI=17% to 54%) survival rate for the CT mice compared with 20% (95% CI=7% to 33 %) in the EX+CT group, 16% (95% CI=2% to 31%) in the EX group and 0% in the CO group. This data suggests that moderate intensity endurance exercise does not significantly influence doxorubicin-induced tumor growth delay in athymic mice implanted with breast carcinoma cell line MDA-MB 231. However, the trend for longer survival with doxorubicin only, suggests that exercise training during chemotherapy may inhibit the efficacy of this therapy. Future studies are underway to explore mechanisms of this potential interaction. This study was supported by a grant from the United States Department of Defense Breast Cancer Research Program - Concept Award.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».