Book Review: Psychopharmacology: Stahl's Essential Psychopharmacology: Neuroscientific Basic and Practical Applications. Third Edition
Notice bibliographique
Résumé
Psychopharmacology Stahl's Essential Psychopharmacology: Neuroscientific Basic and Practical Applications. Third Edition Stephen M Stahl. New York (NY): Cambridge University Press; 2008. 1117 p. US$125 Reviewer rating: Very Good In preface, this book purports to be aimed at psychiatric clinician and not the sophisticated subspecialist in psychopharmocology - sacrificing precision for simplification. This is an aim in which it fails. This is a highly sophisticated text. It is double size of second edition and almost 4 times size of first edition and it has extremely detailed descriptions of mechanisms of drugs. This is a brilliant book, but has far too much information for essential needs of a psychiatrist, even one devoted to psychopharmacology. The author is definitely a unique expert in this subject. Anyone who has attended his lectures is aware of his clarity of thought and vivid, clever graphics he uses to illuminate and demonstrate. In first 5 chapters, Stahl describes activity of neurones and neurotransmitters very clearly, using his typical explanatory figures. This is fascinating material, but of minimal clinical usefulness. In Chapter 6, there is an excellent description and explanation of stress diathesis hypothesis. Chapter 7 explains brain circuits and functional loops - areas of brain talking to each other. The next chapter helps one understand dorsolateral prefrontal cortex and its role in executive functions. Stahl states that circuits that are repeatedly stressed become stress sensitized and vulnerable to breakdown, awaiting provocation leading to precipitation of symptoms. Stahl will help you comprehend diabolical learning, circuit breakdown leading to relapse, and begetting symptoms. Stahl claims that symptoms and circuits can provide a rational approach to selecting and combining treatments. However, his algorithm has: Step 6 add or switch to another treatment if symptom is not relieved; and Step 7 repeat for each symptom until patient is asymptomatic or in remission whenever possible. It appears to me, a detailed knowledge of circuits does not improve my current practice of trial and error based on clinical experience of myself and colleagues. I find myself somewhat dismayed when colleagues talk as if we can use our knowledge of neurotransmitters in this way; I have heard them talk of tickling dopamine receptor. Stahl also states that treatment may reverse vulnerability of circuit and prophylaxis may do same. The absence of treatment may facilitate diabolical learning, recruiting additional sick circuits. He says positron emission tomography and functional magnetic resonance imaging may be avenues to looking at these sick circuits. …
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,010 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».