Impact of the Coronavirus Disease 2019 Pandemic on Global Lung Cancer Clinical Trials: Why It Matters to People With Lung Cancer

The past decade of lung cancer research has seen rapid advances in early detection and treatment and many new Food and Drug Administration–approved therapies for lung cancer. This has largely been possible because of clinical trials. Therapeutic, interventional clinical trials have become a critical component of lung cancer care. The National Comprehensive Cancer Network, the American Society of Clinical Oncology, and the European Society for Medical Oncology guidelines support clinical trial enrollment as standard of care for people with advanced-stage NSCLC and extensive-stage SCLC in first- and subsequent-line settings. As of September 2021, worldwide, there are approximately 1500 actively recruiting interventional lung cancer trials that would require 405,786 participants.1ClinicalTrials.govActively recruiting interventional trials in lung cancer.https://clinicaltrials.gov/Google Scholar Given that an estimated 2.2 million people were diagnosed with lung cancer globally in 2020,2Sung H. Ferlay J. Siegel R.L. et al.Global cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.CA Cancer J Clin. 2021; 71: 209-249Google Scholar these recruitment goals may seem attainable. However, owing to various barriers, only 2% to 8% of people with cancer participate in clinical trials.3Unger J.M. Hershman D.L. Till C. et al.“When Offered to Participate”: a systematic review and meta-analysis of patient agreement to participate in cancer clinical trials.J Natl Cancer Inst. 2021; 113: 244-257Google Scholar This issue has only been exacerbated by the coronavirus disease 2019 (COVID-19) pandemic. Declared a global pandemic in March 2020, COVID-19 has severely disrupted clinical trial conduct. The International Association for the Study of Lung Cancer commissioned a study to understand the impact of the pandemic on global early detection and therapeutics lung cancer trials and mitigation steps taken by trial sites and sponsors to overcome the impact of the pandemic.4Smeltzer M. PL02.09 International Association for the Study of Lung Cancer (IASLC) study of the impacts of COVID-19 on international lung cancer clinical trials.J Thorac Oncol. 2021; 16: S847-S848Google Scholar The study reported a 14% decline in patient enrollment between 2019 (prepandemic) and 2020 (postpandemic). Disruptions were more notable in Phase 1 trials, which have numerous monitoring procedures, and those trials which involve infusion of investigational agents requiring frequent travel to study sites. Study sites reported fewer eligible participants, more deviation from protocol compliance, and increased trial suspensions. Regionally, Latin American sites took longer to recover from low recruitment than North American and Western European sites, suggesting that the impact was amplified in regions that already have fewer trials available. Participants’ top concerns included fear of COVID-19 infection, travel restrictions to trial sites, and securing transportation. This led to logistical challenges such as impaired ability to travel to clinical trial sites. The most effective mitigation strategies reported by sites included flexibility on location requirements (e.g., remote monitoring/diagnostics or using telehealth visits) or timing of procedures (e.g., spacing out visits or assessments) (Fig. 1). Whereas some of these strategies may reduce the burden of trial participation, others may lead to more participant anxiety and increase the impact of disparities among patients in terms of, for example, internet access, device access, or comfort with technology, further impacting trial enrollment. This study provides an excellent framework to reimagine therapeutic, interventional clinical trial design beyond the pandemic. Approaches should not compromise scientific rigor of trials but should be patient centric, equitable, and minimize burden of participation. As a team of thoracic oncology leaders and international patient advocates, we provide recommendations (Table 1) for clinical trial stakeholders to consider as the lung cancer community prepares for the postpandemic era.Table 1Patient-Centric Recommendations for Conduct of Clinical Trials for Thoracic Oncology StakeholdersStakeholdersRecommendationsClinical trial investigators and sponsors•Conduct remote clinical, laboratory, and radiological assessment of on-trial patients as applicable to the phase of the trial•Allow for remote infusions (when risk is deemed to be low; distribution, storage, and recording usage of the study drug is possible at local infusion centers; and adverse event monitoring is carried out real-time) or mail-order targeted therapy delivery•Develop, train staff, and implement digital protocols for:○Patient recruitment, engagement, and retention in clinical trials○ePROs for remote symptom monitoring○Telehealth visits that incorporate video or telephone conferencing—based on individual patient preferencesRegulatory agencies•Provide recommendations on how registrational trials provisionally halted during the pandemic should proceed so that registration is not hampered•Allow flexibility in patient-centric pandemic regulations (e.g., electronic consent, mail-order medication, and remote monitoring) to proceed in the post–COVID-19 era•Provide guidance on how history of or current exposure to SARS-CoV-2 will affect eligibility, trial design, and drug approval and labelingCOVID-19, coronavirus disease 2019; ePRO, electronic patient-reported outcome; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2. Open table in a new tab COVID-19, coronavirus disease 2019; ePRO, electronic patient-reported outcome; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2. Clinical trial complexity has increased over the past decade, with trials requiring 59% more trial-related procedures from 2011 to 2015 compared with those from 2001 to 2005.5Getz K.A. Campo R.A. New benchmarks characterizing growth in protocol design complexity.Ther Innov Regul Sci. 2018; 52: 22-28Google Scholar Almost half of sites surveyed in International Association for the Study of Lung Cancer’s study reported a desire to continue utilizing telehealth, remote monitoring (such as the use of routine blood and urine panels), and electronic consent processes. This focus on increased flexibility will allow more people to participate. Indeed, research suggests that structural barriers, such as travel burden, play an outsized role in low trial participation rates relative to other barriers, such as people not being offered trials or refusing participation.6Unger J.M. Vaidya R. Hershman D.L. Minasian L.M. Fleury M.E. Systematic review and meta-analysis of the magnitude of structural, clinical, and physician and patient barriers to cancer clinical trial participation.J Natl Cancer Inst. 2019; 111: 245-255Google Scholar Flexibility in access to trials can help those who are motivated to join but are deterred owing to burdensome logistics. We encourage investigators and sponsors to develop standardized protocols for remote monitoring (allowing clinical, laboratory, and radiology examinations to be performed close to a participant’s home, with easy assessment by the central trial site), telehealth visits (providing training to trial staff on the use of telehealth for remote procedures and developing and using validated electronic patient-reported outcome measures for symptom monitoring), electronic consent procedures (training staff, including patient advocates in developing electronic consent procedures), providing flexible options (such as video or telephone conferencing), and remote infusions (when risk is deemed to be low, adverse event monitoring is conducted in real-time, and delivery, storage, and recording usage of experimental drug are streamlined) as mechanisms to foster enrollment and participation.7Castelo-Branco L. Awada A. Pentheroudakis G. et al.Beyond the lessons learned from the COVID-19 pandemic: opportunities to optimize clinical trial implementation in oncology.ESMO Open. 2021; 6: 100237Google Scholar,8Flaherty K.T. Doroshow J.H. Galbraith S. et al.Rethinking cancer clinical trial conduct induced by COVID-19: an academic center, industry, government, and regulatory agency perspective.Cancer Discov. 2021; 11: 1881-1885Crossref Scopus (8) Google Scholar It is important to note that digital technologies such as telehealth come with challenges in reimbursement, medical protection, and legal issues with regard to practice of medicine across state or equivalent boundaries. Until there is clarity on how these challenges will be resolved, continued implementation of telehealth will not be possible in the postpandemic era. Digital technologies can facilitate participation for those who need to travel long distances to study sites. However, they need to be implemented in a manner that permits scalability and national and international applicability and that does not introduce additional inequities in access for patients. Another important consideration is the incorporation of optional COVID-19 vaccination as part of trial design.9Desai A. Gainor J.F. Hegde A. et al.COVID-19 vaccine guidance for patients with cancer participating in oncology clinical trials.Nat Rev Clin Oncol. 2021; 18: 313-319Google Scholar Such designs will help people understand that they can choose to be vaccinated and participate in a clinical trial at the same time. Lung cancer research is funded by many different private and public sources, varying by country, and the impact of the pandemic on lung cancer research is still being evaluated. The role of nonpharmaceutical funders in drug development was underscored in a recent study that revealed that a substantial fraction of spending by the National Institutes of Health, the largest government funding agency in the United States, is contributing directly or indirectly to new therapies for all diseases, including lung cancer.10Galkina Cleary E. Beierlein J.M. Khanuja N.S. McNamee L.M. Ledley F.D. Contribution of NIH funding to new drug approvals 2010-2016.Proc Natl Acad Sci U S A. 2018; 115: 2329-2334Google Scholar Governments and industry have focused pandemic-era funding on diagnostics, vaccines, and treatments for COVID-19, leaving research charities and not-for-profit organizations uncertain of future funding. Half of the Global Lung Cancer Coalition’s members have seen income decreases since the start of the pandemic.11Global Lung Cancer CoalitionImpact of COVID-19: findings from a GLCC members survey.https://www.lungcancercoalition.org/2020/06/19/impact-of-covid-19-findings-from-a-glcc-members-survey/Date accessed: September 21, 2021Google Scholar Large cancer research funders, such as the American Cancer Society, Canadian Cancer Society, and Cancer Research UK have seen large income reductions, leading to reduced research funding.12Burki T.K. Cuts in cancer research funding due to COVID-19.Lancet Oncol. 2021; 22: e6Google Scholar Lung cancer has traditionally been underfunded as a disease, with the National Institutes of Health allocating only 6% of their overall cancer research funding to lung cancer. We urge government funding agencies and private philanthropies to continue to invest in life-saving research that will fuel the drug development pipeline. Lung cancer now leads the solid tumor oncology space with the highest number of treatment options in clinical trials. A decrease in funding will impede progress against this disease. During the early stages of the pandemic, regulatory agencies, such as the U.S. Food and Drug Administration (Silver Spring, MD), the European Medicines Agency, Health Products Regulatory Authority (Dublin, Ireland), and the Healthcare Products Regulatory Agency (London, United Kingdom), rapidly issued guidance on clinical trial conduct. Common themes with direct participant impact revolved around allowing remote monitoring of certain trials through local labs, the impact of COVID-19 status on trial eligibility and participation, mail-order medication delivery, and use of electronic consent procedures. As advocates, we applaud regulators for reacting to the pandemic to ensure that clinical trials continue. It is currently unclear how regulators see these strategies being incorporated into clinical trial design beyond the pandemic. We hope that positive changes made during the pandemic will remain in postpandemic times, given that these changes reduced existing (pre–COVID-19) barriers. Clinical investigators and sponsors will be open to adopting flexible trial designs only if regulators and health technology assessments do not see these designs as impeding registration, drug approval, and reimbursement. Another worry is that changes or a temporary halt to existing trials early in the pandemic will affect the quality or interpretability of trial data and therefore influence future licensing decisions. We encourage regulators to weigh current modifications and issue guidance on how they propose to proceed with regulatory decisions, especially for pivotal clinical trials that are still ongoing. Finally, we request regulators to provide clear guidance on how history of or current exposure to severe acute respiratory syndrome coronavirus 2 will affect eligibility, trial design, and drug approval and labeling. The COVID-19 pandemic presented an unprecedented global health challenge, the effects of which will continue to be felt for years to come. It also revealed how the global scientific community rapidly pivoted and partnered to develop life-saving vaccines that become available in a time frame that most felt was unattainable. The lung cancer community also rapidly mobilized and formed international consortiums, such as the COVID-19 and Lung Cancer Consortium and TERAVOLT, to understand the impact of the pandemic on the care of patients. This momentum bears testimony to the power of science and collaboration. Government agencies (such as the National Cancer Institute in the United States) and professional organizations (such as the American Society of Clinical Oncology and the European Society for Medical Oncology) have issued guidance on clinical trial conduct during the pandemic.7Castelo-Branco L. Awada A. Pentheroudakis G. et al.Beyond the lessons learned from the COVID-19 pandemic: opportunities to optimize clinical trial implementation in oncology.ESMO Open. 2021; 6: 100237Google Scholar,8Flaherty K.T. Doroshow J.H. Galbraith S. et al.Rethinking cancer clinical trial conduct induced by COVID-19: an academic center, industry, government, and regulatory agency perspective.Cancer Discov. 2021; 11: 1881-1885Crossref Scopus (8) Google Scholar,13Doherty G.J. Goksu M. de Paula B.H.R. Rethinking cancer clinical trials for COVID-19 and beyond.Nat Cancer. 2020; 1: 568-572Google Scholar The purpose of this commentary is to provide the patient advocacy perspective to these recommendations. We acknowledge that incorporating recommendations provided in the framework in this commentary is complex and contingent on several site-specific, policy-specific, and country-specific factors. As advocates, we remain optimistic that the lung cancer clinical trial ecosystem will continue to learn, partner, and innovate—to ensure that clinical trial designs become more patient-centric and that more people continue to have access to life-saving therapies through these trials. Upal Basu Roy: Conceptualization. Upal Basu Roy, Anne-Marie Baird, Andrew Ciupek, Jesme Fox, Eugene Manley, Jr., Kim Norris: Writing - original draft. Upal Basu Roy, Anne-Marie Baird, Andrew Ciupek, Jesme Fox, Eugene Manley, Jr., Kim Norris, Giorgio V. Scagliotti, Heather A. Wakelee, Tetsuya Mitsudomi, Russell J. Clark, Renee Arndt, Fred R. Hirsch, Paul A. Bunn, Matthew P. Smeltzer: Writing - review & editing.

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