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RevueThe Lancet Oncology · 2021
Typearticle
Langueen
DomaineMedicine
ThématiqueChildhood Cancer Survivors' Quality of Life
Établissements canadiensnon disponible
Organismes subventionnairesEIT HealthFogarty International CenterNational Cancer InstituteNational Human Genome Research InstituteGuy's and St Thomas' NHS Foundation TrustInstituto de Salud Carlos IIISydney Medical SchoolFundação para a Ciência e a TecnologiaNational Health and Medical Research CouncilMedical Research CouncilSchool of Public Health and Family Medicine, University of Cape TownCollege of Science and Engineering, University of MinnesotaUniversity of Florida HealthUniversity of Oklahoma Health Sciences CenterCollege of Engineering, Michigan State UniversityUniversity of Veterinary and Animal SciencesDirectorate for Biological SciencesDebre Markos UniversityGeorge Institute for Global HealthKing Faisal UniversityUniversité de Versailles Saint-Quentin-en-YvelinesMadda Walabu UniversityKing Saud bin Abdulaziz University for Health ScienceAlfaisal UniversityLaboratório Associado para a Química VerdeRUDN UniversityUniversitas PadjadjaranJahrom University of Medical SciencesUniversity at BuffaloSamara UniversityImam Abdulrahman Bin Faisal UniversityRazi Vaccine and Serum Research InstituteLorestan University of Medical SciencesKwame Nkrumah University of Science and TechnologyPeking Union Medical CollegeUniversity of TorontoImperial College LondonSyöpäsäätiöUniversidade Federal do Rio Grande do SulUniversity of ColomboNovo Nordisk FondenWalailak UniversityUniversity of CalcuttaThe Wellcome Trust DBT India AllianceShenzhen UniversityNSW Ministry of HealthUniversità degli Studi di MilanoPomorski Uniwersytet Medyczny W SzczecinieUniversitas AirlanggaYasuj University of Medical SciencesTarbiat Modares UniversityDepartment of Biotechnology, Ministry of Science and Technology, IndiaUniversity of SulaimaniUniversity of California, Los AngelesChina Medical UniversityCairo UniversitySecretaría Nacional de Ciencia, Tecnología e InnovaciónUniversidade do PortoUniversity of TsukubaUniversity of DhakaUniversitatea SapientiaUniversitat de BarcelonaFasa University of Medical SciencesUniversity of South CarolinaQazvin University of Medical SciencesChinese Center for Disease Control and PreventionOulun YliopistoHokkaido UniversityUniversità di BolognaUniversitatea de Medicină şi Farmacie "Carol Davila" BucureştiShahid Beheshti University of Medical SciencesZanjan University of Medical SciencesUniversity of GondarUnited Arab Emirates UniversityKermanshah University of Medical SciencesAutoritatea Natională pentru Cercetare StiintificăWolkite UniversityUniversiti Sultan Zainal AbidinMenofia UniversityGöteborgs UniversitetShahrekord University of Medical SciencesLiverpool University Hospitals NHS Foundation TrustCentro de Investigación Biomédica en Red de Salud MentalMonash UniversityUniversità degli Studi del Piemonte OrientaleUniversidade de São PauloBloomberg PhilanthropiesDepartment of Social Services, Australian GovernmentJawaharlal Institute Of Postgraduate Medical Education and ResearchUniversitetet i OsloTartu ÜlikoolDanmarks Tekniske UniversitetBirjand University of Medical SciencesUniversitetet i BergenMazandaran University of Medical SciencesShahrekord UniversityHaramaya UniversityTanta UniversityHamadan University of Medical SciencesSemmelweis EgyetemUniversiti Kebangsaan MalaysiaUniversity of WaterlooKuwait UniversityTabriz University of Medical SciencesAddis Ababa UniversitySultan Qaboos UniversitySeoul National University HospitalQatar UniversityBabol University of Medical SciencesShahroud University of Medical SciencesNational Center for Advancing Translational SciencesPäivikki ja Sakari Sohlbergin SäätiöIndian Council of Medical ResearchMahidol UniversityKing Abdulaziz UniversityKarolinska InstitutetUniversità degli Studi di GenovaUniversidade Federal de Santa CatarinaEastern Virginia Medical SchoolIsfahan University of Medical SciencesUniversitas Ahmad DahlanIslamic Azad UniversitySeoul National UniversityGachon UniversityAjou UniversityCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorAlborz University of Medical SciencesUniversidad Nacional de ColombiaNankai UniversityFlinders UniversityDebre Tabor UniversityUniversiteit UtrechtCurtin University of TechnologyUniversity of South AustraliaInstituto Politécnico do PortoUniversity of Science and Technology of ChinaUniversity of PennsylvaniaTsinghua UniversityNational Taiwan Normal UniversityNational and Kapodistrian University of AthensTehran University of Medical Sciences and Health ServicesSouth Eastern Sydney Local Health DistrictMcGovern Medical SchoolUniversity of Technology SydneyCharles Sturt UniversityUniversity of LeicesterDeutsche ForschungsgemeinschaftAmity UniversityMinistério da Ciência, Tecnologia e Ensino SuperiorSigrid Juséliuksen SäätiöQueensland University of TechnologyLondon South Bank UniversityUniversity of OxfordKing's College LondonUniversity of QueenslandNational Institute for Health and Care ResearchAmerican Lebanese Syrian Associated CharitiesUniwersytet Jagielloński Collegium MedicumShaheed Benazir Bhutto UniversitySanjay Gandhi Postgraduate Institute of Medical SciencesTechnische Universität MünchenArabian Gulf UniversityTulane UniversityNeyshabur University of Medical SciencesKashan University of Medical SciencesMacquarie UniversityJordan University of Science and TechnologyHamad Bin Khalifa UniversityShanghai Jiao Tong UniversityKasturba Medical College, ManipalKrishna Institute Of Medical Sciences Deemed To Be UniversitySamsungApplied Molecular Biosciences UnitPublic Health Foundation of IndiaAustralian Catholic UniversityUniversity of Cape TownKhalifa University of Science, Technology and ResearchUniversity of OttawaNational Authority for Scientific Research and InnovationAksum UniversityJames Cook UniversityTrường Đại học Duy TânSocial Science Research CouncilOhio State UniversityJohns Hopkins UniversityWellcome TrustInstitució Catalana de Recerca i Estudis AvançatsUniversidade Federal de Juiz de ForaBill and Melinda Gates FoundationIran University of Medical SciencesStudent Research Committee, Tabriz University of Medical SciencesLa Trobe UniversityDeakin UniversityUniwersytet ŁódzkiHelsingin YliopistoTufts Medical CenterUniversidade de LisboaOttawa Hospital Research InstituteXiamen UniversityJazan UniversityUniversiti Brunei DarussalamUniversity of RochesterChinese University of Hong KongFlorida Department of HealthGeorgetown UniversityNational Center of Neurology and PsychiatryUniversity of Agriculture, FaisalabadAlexander von Humboldt-StiftungUniversity of Southern CaliforniaUniversity of OklahomaUniversity of ZanjanFlorida International UniversityJimma UniversityZahedan University of Medical SciencesHarvard UniversityDeutsches KrebsforschungszentrumConselho Nacional de Desenvolvimento Científico e TecnológicoUniverzita Karlova v PrazeMichigan State UniversityTaipei Medical UniversityU.S. President’s Emergency Plan for AIDS ReliefCleveland ClinicUniversità di CataniaEesti TeadusagentuurWayne State UniversityNational Institutes of HealthBanaras Hindu UniversityCase Western Reserve UniversityHamad Medical CorporationUniversity of TabrizEuropean CommissionYasouj UniversityOhio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research InstituteJackson State UniversityUnited Nations Population FundRush UniversityCentre Hospitalier Universitaire VaudoisNew Mexico State UniversityNazarbayev UniversityWuhan UniversityAlberta Health ServicesSt. Baldrick's Foundation
Mots-clésBurden of diseaseDiseaseMedicineCancerDisease burdenGerontologyInternal medicine
Résumé
récupéré en direct d'OpenAlexBACKGROUND: In estimating the global burden of cancer, adolescents and young adults with cancer are often overlooked, despite being a distinct subgroup with unique epidemiology, clinical care needs, and societal impact. Comprehensive estimates of the global cancer burden in adolescents and young adults (aged 15-39 years) are lacking. To address this gap, we analysed results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, with a focus on the outcome of disability-adjusted life-years (DALYs), to inform global cancer control measures in adolescents and young adults. METHODS: Using the GBD 2019 methodology, international mortality data were collected from vital registration systems, verbal autopsies, and population-based cancer registry inputs modelled with mortality-to-incidence ratios (MIRs). Incidence was computed with mortality estimates and corresponding MIRs. Prevalence estimates were calculated using modelled survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated as age-specific cancer deaths multiplied by the standard life expectancy at the age of death. The main outcome was DALYs (the sum of YLLs and YLDs). Estimates were presented globally and by Socio-demographic Index (SDI) quintiles (countries ranked and divided into five equal SDI groups), and all estimates were presented with corresponding 95% uncertainty intervals (UIs). For this analysis, we used the age range of 15-39 years to define adolescents and young adults. FINDINGS: There were 1·19 million (95% UI 1·11-1·28) incident cancer cases and 396 000 (370 000-425 000) deaths due to cancer among people aged 15-39 years worldwide in 2019. The highest age-standardised incidence rates occurred in high SDI (59·6 [54·5-65·7] per 100 000 person-years) and high-middle SDI countries (53·2 [48·8-57·9] per 100 000 person-years), while the highest age-standardised mortality rates were in low-middle SDI (14·2 [12·9-15·6] per 100 000 person-years) and middle SDI (13·6 [12·6-14·8] per 100 000 person-years) countries. In 2019, adolescent and young adult cancers contributed 23·5 million (21·9-25·2) DALYs to the global burden of disease, of which 2·7% (1·9-3·6) came from YLDs and 97·3% (96·4-98·1) from YLLs. Cancer was the fourth leading cause of death and tenth leading cause of DALYs in adolescents and young adults globally. INTERPRETATION: Adolescent and young adult cancers contributed substantially to the overall adolescent and young adult disease burden globally in 2019. These results provide new insights into the distribution and magnitude of the adolescent and young adult cancer burden around the world. With notable differences observed across SDI settings, these estimates can inform global and country-level cancer control efforts. FUNDING: Bill & Melinda Gates Foundation, American Lebanese Syrian Associated Charities, St Baldrick's Foundation, and the National Cancer Institute.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
score de la tête « metaresearch » (Codex)0,002
score de la tête « metaresearch » (Gemma)0,001
Version: codex-gemma-dda1882f352aStatut de validation: machine_predicted_unvalidated
Catégories candidatesaucune
Catégories consensuellesaucune
DomaineSignal candidat: aucune · Signal consensuel: aucune
Devis d'étudeSignal candidat: Observationnel · Signal consensuel: Observationnel
GenreSignal candidat: Empirique · Signal consensuel: Empirique
Score de désaccord entre enseignants0,083
Score d'incertitude au seuil0,986
Scores Codex et Gemma par catégorie
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
Tête enseignante Opus0,033
Tête enseignante GPT0,379
Écart entre enseignants0,346 · la distance entre les deux têtes enseignantes sur ce seul travail
Statut de validationscore_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle
