09 / Optimal dose horse antithymocyte globulin for the treatment of adult patients with aplastic anemia: a p rospective randomized comparative study
Notice bibliographique
Résumé
ASSESSMENT OF SYMPTOM BURDEN AMONG PATIENTS DIAGNOSED WITH MULTIPLE MYELOMA (MM) ADMITTED TO RECEIVE CHEMOTHERAPY AT THE INSTITUTE FOR ONCOLOGY AND RADIOLOGY OF SERBIA (IORS)F. Djordjevic 1, N.Stanic11Institute of Oncology and Radiology of Serbia, Belgrade, SerbiaKEY WORDS: multiple myeloma, symptom burden, The Edmonton Symptom Assessment System (ESAS)IntroductionPatients with MM represent a vulnerable population of patients who may experience a range of symptoms induced by cancer or its treatment. The data describing the incidence and severity of symptoms before, during and after chemotherapy are lacking. Better description of symptom burden will enable individual, symptom-based tailoring of anti-cancer treatment. Better patient education to report symptoms leads to better symptom management, and improvement in quality of life. ObjectivesThe objective of this paper is to assess the symptom burden using the Edmonton Symptom Assessment System (ESAS) in patients with MM, who were scheduled to receive first cycle of chemotherapy at the IORS.AimsTo improve symptom control for patients with MM.MethodsESAS questionnaire (Edmonton system assessment scale) is designed to assist in the assessment of the most frequent symptoms in patients with advanced cancer, namely: pain, tiredness, nausea, depression, anxiety, drowsiness, loss of appetite, shortness of breath, overall well-being. The severity at the time of assessment of each symptom is rated from 0 to 10 on a numerical scale; with 0 meaning that the symptom is absent and 10 that it is the worst possible severity. ESAS was used to assess symptoms in patients with MM who were admitted to start chemotherapy at the IORS for the first time. Descriptive statistics methods were used to analyze collected data.ResultsESAS records were collected from 20 patients (11 male and 9 female) with the median age of 63 years (range 41-80). Majority of patients (90%) had performance status (PS) of 2. All nine ESAS symptoms were reported as moderate to severe (more than 4/10) by majority of patients with mean scores of 5.46, 4.71, 5.80, 4.01, 6.03, 7.02, 4.04, 7.19, 7.06 for pain, nausea, lack of appetite, shortness of breath, fatigue, depression, drowsiness, anxiety and well-being, respectively.ConclusionsHospitalized patients with MM experience substantial physical and psychological symptoms. There is a concerning proportion of reported depression and anxiety. Our data demonstrate the need for efforts to alleviate the physical symptoms experienced by this population, while also seeking to understand and address their psychological needs. Our research supports use of ESAS as a useful, easy and not time-consuming screening tool for symptom burden. Further research will be conducted in order to examine the impact of ESAS in treatment decision-making process.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,002 | 0,002 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,005 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».