The relative effectiveness of action potential therapy versus local action transcutaneous patches containing Flurbiprofen, for the treatment of osteoarthrltls of the knee
Notice bibliographique
Résumé
The purpose of this study was to determine the relative effectiveness of action potential therapy versus local action transcutaneous patches containing Flurbiprofen in the treatment of Osteoarthritis of the knee. The study was a prospective, randomized, study involving 60 subjects, 30 in each group, which were selected from the general population. Group one received action potential therapy and a sham patch, while group two received Local Action Transcutaneous Flurbiprofen and sham action potential therapy. Patients received six treatments over a period of two weeks. For the first five visits the patients received action potential therapy, if they were in group one active APT while if they were in group two, sham action potential therapy. Both groups of people received two patches after each visit which they were to use the following day. Those patients in group one received sham patches whilst those in group two received genuine LAT Flurbiprofen patches. Subjective assessment was by means of the short form Me Gill pain Questionnaire, Numerical Pain Rating Scale - 101 Questionnaire and the Western Ontario and McMaster Univerisities Osteoartritis index (Pain, stiffness and physical function subsections). Objective assessment of tenderness was made, by means of an algometer, range of motion was measured through the use of the universal goniometer, and assessment of effusion (swelling) through the use of a standard tape measure. Assessments were taken on the first, third and sixth consultations for all subjective and objective measures. The sixth visit was a data capture visit only. Statistical analysis was completed under the supervision ofMr K Thomas at Technikon Natal, at a 95% confidence interval. The parametric two-sample paired t-test and the non-parametric Wilcoxon signed rank tests were used to analyze data within each group, while the parametric two-sample unpaired t-test and non-parametric Mann-Whitney unpaired U test were used to analyse the data between each group. In terms of objective findings both groups showed a significant overall increase in pressure pain threshold (algometeric readings), a decrease in effusion (ifit was present) and improvement in the range of knee flexion. In terms of patients' subjective response to treatment, both groups showed a significant overall decrease in pain perception (NRS-lOl and McGill Pain Questionnaire) and furthermore an improvement in pain, stiffuess and physical function (as measured by the WOMAC OA index) was also seen in both groups. No significant differences were found between the groups for the subjective measures, a statistically significant difference was however found between the algometric measures of the first, third and sixth visits indicating a greater improvement within treatment group 2 (LAT flurbiprofen patches) in terms of pressure pain threshold
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,004 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».