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Enregistrement W4220940264 · doi:10.31989/ffhd.v12i4.905

Effective body recomposition vs. misconceptions of the traditional weight loss strategies: TRCAP21 - a novel technological breakthrough in body recomposition

2022· article· en· W4220940264 sur OpenAlexaff
Debasis Bagchi, Bernard W. Downs, Samudra Prosad Banik, Manashi Bagchi, Steve Kushner, Sanjoy Chakraborty, Bruce J. Morrison, Stephen Hesson

Notice bibliographique

RevueFunctional Foods in Health and Disease · 2022
Typearticle
Langueen
DomaineBiochemistry, Genetics and Molecular Biology
ThématiqueGenetics, Aging, and Longevity in Model Organisms
Établissements canadiensNutrition International
Organismes subventionnairesnon disponible
Mots-clésMedicineWeight lossObesityWaistPlaceboOverweightInternal medicinePhysiologyPathology

Résumé

récupéré en direct d'OpenAlex

Background: The prevalence of obesity has increased an astounding 30.5% to 42.2% over the last two decades despite numerous weight loss products and programs, thus qualifying it as an epidemic. Fat is the lightest of macromolecules, the highest energy reserve of the body, and the last reservoir of survival insurance to be expended. Water, muscle, and electrolytes are diminished prior to the expenditure of fat resources, the primary cause of rapid weight loss. Contrary to popular belief that only “weight gain” is the sole and correct parameter for evaluating healthy body recomposition, there are no less than 10 additional factors that contribute to a reduction in metabolic rate and an increase in fat storage. These are mostly ignored from considerations regarding the etiology of obesity. Our laboratory developed a novel formulation of D-ribose nicotinamide, alpha glycerol phosphorylcholine and four other evidence-based botanical constituents encapsulated in a Prodosomed stimulant- and sugar-free TRCAP21 (TrimRoxTM) formulation that effectively addresses those contributing factors. To investigate the feasibility of doing a 90-day randomized, double-blind placebo-controlled investigation, we conducted a 21-day concept validation pilot study on TRCAP21 in 9 subjects to assess changes in various body parts, including chest, upper arms, waist/belly, hips, and thighs, as well as body weight. Objective: This physician-supervised 21-day concept validation pilot study on TRCAP21 was conducted on 9 subjects to determine changes in anthropometric parameters including chest, upper arms, waist/belly, hips, and thighs, as well as body weight, and determine the effect of TRCAP21 on energy, mood, satiety, and sugar cravings. Materials and Methods: The study was conducted on nine male and female subjects (age: 47-70 years) to assess the efficacy of TrimRoxTM over a period of 21 consecutive days. Body weights and anthropometric measurements were conducted at the initiation and termination of the study. The effect of TRCAP21 was evaluated on energy level, mood elevation, satiety level, sugar cravings, overall health, and adverse events in the subjects. Results: The results demonstrated that all subjects experienced a reduction in size of one or more these body parts. In addition, it also led to significant improvements in mood elevation, satiety, reduced sugar cravings, elevated energy levels and overall mental and physical health. Intake of 1 packet twice a day (BID) before meals resulted in a significantly greater reduction of body measurements than consuming it once a day (OID). Surprisingly, body weight was reduced in all nine subjects from 2 lbs. to 11 lbs. The randomized double-blind placebo-controlled study is underway to confirm and further substantiate these findings. Conclusion: The TRCAP21 Prodosomed nutraceutical formulation combines the evidence-based efficacy of 6 key constituents, mostly of botanical origin, that act synergistically to restore aerobic cellular metabolism, boost energy level, mood elevation, improve satiety, reduce sugar cravings, reduce body fat in various body compartments as well as weight and improve overall health. Owing to the encapsulation of the components in unique concentric layers of liposome, their release takes place in a sustained and sequential manner. It will be worthwhile to explore its effect on the Gut-Brain Axis, especially the associated microbiome in order to obtain further insights to more accurately define the multiple mechanisms of action. Keywords: obesity, weight management, body recomposition, Aerobic body homeostasis, prodosome®, herbal nutraceuticals

Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.

Comment cette classification a été obtenuedéplier

Prédiction distillée sur la base complète

Imitation des enseignants

Ni prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.

score de la tête « metaresearch » (Codex)0,000
score de la tête « metaresearch » (Gemma)0,000
Version: codex-gemma-dda1882f352aStatut de validation: machine_predicted_unvalidated
Catégories candidatesaucune
Catégories consensuellesaucune
DomaineSignal candidat: aucune · Signal consensuel: aucune
Devis d'étudeSignal candidat: Observationnel · Signal consensuel: Observationnel
GenreSignal candidat: Empirique · Signal consensuel: Empirique
Score de désaccord entre enseignants0,556
Score d'incertitude au seuil0,540

Scores Codex et Gemma par catégorie

CatégorieCodexGemma
Métarecherche0,0000,000
Méta-épidémiologie (sens strict)0,0000,000
Méta-épidémiologie (sens large)0,0000,000
Bibliométrie0,0000,000
Études des sciences et des technologies0,0000,000
Communication savante0,0000,000
Science ouverte0,0000,000
Intégrité de la recherche0,0000,000
Charge utile insuffisante (le modèle a refusé de juger)0,0000,000

Scores machine (provisoires)

Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.

Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.

Tête enseignante Opus0,017
Tête enseignante GPT0,254
Écart entre enseignants0,237 · la distance entre les deux têtes enseignantes sur ce seul travail
Statut de validationscore_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle

Classification

machine, non validée

Prédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.

Les modèles n’ont appliqué aucune catégorie : rien dans la taxonomie ne correspondait à ce travail.
Devis d'étudeObservationnel
Domainenon disponible
GenreEmpirique

Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».

En bref

Citations2
Publié2022
Routes d'admission1
Résumé présentoui

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