P202 Impact of ‘moderate' active RA on patient lives
Notice bibliographique
Résumé
Abstract Background/Aims The objective of this survey was to highlight the everyday impact of living with active Rheumatoid Arthritis for people not meeting the eligibility criteria (pre-July 2021), to be treated with advanced therapies. Methods NRAS wanted to reach people living with RA for more than 2 years but not being treated with any advanced therapies with a national survey to gauge if they had active disease that was not well controlled and the impact of that active disease on their lives. The survey was designed to capture demographics, current treatment, frequency of RA flares, impact of disease (utilising the validated tool of RAID) as well as work status and restrictions on lifestyle. The national online survey was distributed via all NRAS social media platforms as well as email. Results 612 responses from across the UK with a mean age of 59 years were gathered. 88% were female and 37.7% had a disease duration of 2-5 years with a further 27.9% with disease duration of 5-10 years. 90% declared having RA flare in the previous 12 months with 23% reporting having had six or more flares within the year. A total RAID score was calculated for 611 respondents. A RAID patient acceptable state was recorded in only 12.4%. 74.3% scored sleep problems and 72% fatigue in the high range. Working hours alteration was reported by 70% of respondent. The RAID scores were significantly predictive of number of flares. Conclusion Patients not currently treated with biologics/biosimilars or targeted synthetic DMARDs experience profound difficulties affecting their health, emotional state, work and families. NRAS advocate that patient reported measures be used to facilitate holistic care, addressing inflammation and other consequences of RA on everyday life. Since this piece of work was carried out the threshold for accessing some advanced therapies has been lowered by NICE meaning that in England and Wales many of these people will now have access to being treated on an advanced therapy however there still exists issues in Scotland and Northern Ireland in being able to offer such treatments to those with RA disease activity score of less than 5.1 as well as cost barriers. Disclosure C. Jacklin: None. E. Nikiphorou: None. P. Kiely: None. H. Jacklin: None. A. Bosworth: None.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,005 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,002 | 0,001 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,028 | 0,003 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».