Cover Picture: Proteomics 20'11
Notice bibliographique
Résumé
Abstract A cell of two minds Stem cells have two principal tasks: (i) being prepared to replicate vegetatively on command, and (ii) being prepared to replicate differentially on command. It is always helpful if there is a way of recognizing the small pools of cells with these capabilities, preferably biomarkers that can be recognized quickly, cleanly and sensitively. One source that has not been thoroughly explored is very small peptides, MW <5 kDa. Maltman et al. report here on an enhanced protocol that has some interesting properties when used with neural progenitor cells. The procedure does not require a label, and uses LC‐MALDI‐TOF/TOF for analysis. It identified 12 different proteins on the basis of differentiated abundance, including nestin, vimentin, and GFAP, which are associated with neural development, some up‐regulated, some down‐regulated. Maltman, D. J. et al., Proteomics 2011, 11 , 3992–4006. Re‐virginized mouse mammary glands You might think the mouse mammary gland system was designed by Richard Branson but we cannot give Sir Richard credit for this one. The mouse system, unlike the human mammary gland can, in large part, be recycled. During pregnancy, the luminal cells are directed to re‐differentiate into the milk‐producing aveoli (MaSC) until the end of lactation. The MaSC niche also directs neural cell reprogramming. Ji et al. purified fractions from cultured mammary tissue, adherent plasma membrane and sub‐fractions. Comparative proteomic analysis revealed a number of molecules and signaling pathways were involved, such as Wnt and Eph/ephrin signaling, and integrin‐mediated interactions. The analysis hinted at a number of solutions, but none answers all the issues all the time. Ji, H. et al., Proteomics 2011, 11 , 4029–4039. The mystery in the can kicked down the road If you were a small boy who lived in a small US town in the 1950s, an image from the recent US congressional hearings resonated. You, too, kicked a can all the way home. You also wore blue jeans with pre‐patched knees and had to wait until Saturday for the next episode of “Sergeant Preston of the Yukon” at the only movie theater in town. You shared your bedroom with your younger brother, so the mess was always his. Moving to the future now with SAHA (a potent blocker of histone deacetylase inhibitor) and HDAC (a histone deacetylase), they too, exhibit can‐can interactions if examined closely, so Fischer et al. created a small, three‐pronged binding molecule that could selectively identify a non‐canonical SAHA binder. The most interesting target found was isochorismatase (ISOC2), which has been implicated in regulation of tumor suppressor p16(INK4A). Interesting soup in that can... Fischer, J. J. et al., Proteomics 2011, 11 , 4096–4104.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,001 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,003 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».