IJU this issue

Masato Fujisawa md phdAssociate Editor This issue consists of one Guidelines, one Review Article, four Original Articles, three Short Communications and two other reports. These studies mainly focus on topics closely associated with clinical aspects, which urologists frequently encounter in the clinical practice; accordingly, I believe that the content of this issue might help provide useful information to resolve several problems in various fields of clinical urology. This issue starts with updated guidelines on prostate-specific antigen (PSA)-based screening for prostate cancer by Ito et al. (Maebashi, Japan). Considering the significantly low exposure rate of prostate cancer screening using PSA in Japan compared with those in the Western countries, both the committee of these guidelines and the Japanese Urological Association strongly emphasize that PSA screening should be offered to all men at risk of developing prostate cancer to improve the prostate cancer-specific survival. This issue also includes an interesting review on semen tests by Samplaski et al. (Cleveland, USA). In this review, the authors describe the utility of specialized semen tests developed to assess functional aspects of sperm for the diagnosis of male infertility. Of these, several tests using molecular biological techniques, such as microarray technology, could also be particularly promising tools to elucidate the mechanism involved in male infertility that is undetected by conventional semen tests. Consequently, four excellent Original Articles are provided. Kondo et al. (Tokyo, Japan) report the prognostic significance of complete lymphadectomy in patients with urothelial carcinoma of the upper urinary tract. In this series, the total number of removed lymph nodes had no impact on the survival of patients with this disease, whereas lymph node dissection according to the template appeared to result in the significant improvement of cancer-specific survival in these patients. Based on these findings, dissecting all the regional nodes would be recommended as a final goal of lymphadenectomy for upper urinary tract cancer. Consistent with several approaches applied to improve the outcomes of prostate biopsy, Miyagawa et al. (Hitachi, Japan) report a novel device, namely real-time virtual sonography (RVS), introduced into targeted prostate biopsy. A total of 192 biopsy cores were obtained with RVS, and 62 of the 192 (32%) were positive for prostate cancer; however, just 75 of the 833 cores obtained by conventional random biopsy were diagnosed as containing cancer. This finding suggests the effectiveness of RVS for diagnosing suspicious lesions detected with radiological modalities. Budas et al. (Montreal, Canada) report an interesting model for identifying appropriate candidates for low-dose rate brachytherapy considering the impact of Gleason sum upgrading. In their series consisting of 414 patients fulfilling the criteria for low-dose brachytherapy, but undergoing radical prostatectomy, 35% of these patients showed Gleason sum upgrading. When applied to this cohort, the novel nomogram for low-dose brachytherapy established in this study showed high accuracy compared with the existing nomogram. Miyakita et al. (Oiso, Japan) carried out a randomized multicenter study comparing the short-term effects of crossover treatment with silodosin and tamsulosin hydrochloride on benign prostatic hyperplasia patients with lower urinary tract symptoms. According to this trial, silodosin showed excellent efficacy in both subjective symptoms and quality of life during initial, as well as crossover, treatments compared with tamsulosin. However, the incidence of adverse drug reactions was frequently observed in the silodosin group. This issue also includes three short communications describing important topics. Minagawa et al. (Nagano, Japan) introduce a new technique of prostate biopsy, known as high-consistency area-targeting biopsy. Terakawa et al. (Kobe, Japan) report the preliminary outcomes of salvage chemotherapy using methotrexate, etoposide and actinomycin D in men with non-seminomatous germ cell tumor with a choriocarcinoma component. Heer et al. (Newcastle, UK) investigated the detailed clinicopathological features of Leydig cell tumors, the most common intestinal neoplasm of the testes. It is expected that the studies carried out in these three short articles will be expanded to strengthen the currently described findings.

Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.