Program: Friday, October 10, 2003

89. CSBMCB-Roche Diagnostics Award Lecture08:00–08:40, Room 71089.1 The Role of Genomics in Cancer ResearchVictor Ling, University of British Columbia, Vancouver, BC, Canada90. Severo Ochoa Lecture08:45–09:25, Room 71090.1 TFIIH Enters the ClinicJean-Marc Egly, Institut de Génétique et de Biologie Moleculaire et Cellulaire, Strasbourg, France09:25 Coffee Break91. Concurrent Session 27Splicing and Editing of RNAChair: Liam P. Keegan, Medical Research Council, Edinburgh, United KingdomCo-Chair: Benoit Chabot, Départment of Microbiology and Infectious Diseases, Faculty of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada09:35–12:45, Room 520CF91.1 Proteins That Function at Early Stages of Spliceosome AssemblyAngela Krämer, University of Geneva, Geneva, Switzerland91.2 Modulation of A-to-I Editing by Functional Nucleolar SequestrationRonald Emeson, Vanderbilt University, Nashville, TN, United States91.3 Roles of the Proteins in the Trypanosome RNA Editing ComplexBarbara Sollner-Webb, The Johns Hopkins University School of Medicine, Baltimore, MD, United States91.4 Editing Flies to DeathLiam P. Keegan, Medical Research Council, Edinburgh, United Kingdom92. Concurrent Session 28Education in the Molecular Life Sciences: The Central Role of Biochemistry and BiologyChair: Cecilia Hidalgo, University of Chile, Santiago, ChileCo-Chair: Ellis J. Bell, University of Richmond, Gottwald Science Center, Richmond, VA, United States09:35–11:45, Room 514ABC92.1 Bridging the Gap in Biochemistry Between Secondary School and UniversityJoan Guinovart, University of Barcelona, Barcelona, Spain92.2 An “Inverted Pyramid” Approach to Upgrade Biology Teachers' Skills That Starts with Newspaper ReportsYedy Israel, Universidad de Chile, Santiago, Chile92.3 More About Less: Defining the Essential CoreRobert Learmonth, University of Southern Queensland, Toowoomba, Australia92.4 Education in the Molecular Life Sciences: The Central Role of Biochemistry and Molecular BiologyEllis J. Bell, University of Richmond, Richmond, VA, United States93. Concurrent Session 29Mitochondrial Biogenesis and EvolutionChair: Michael Gray, Dalhousie University, Halifax, NS, CanadaCo-Chair: Heidi McBride, University Of Ottawa Heart Institute, Ottawa, ON, Canada09:35–11:05, Room 520BE93.1 Diversity and Evolution of Mitochondrial Genome Architecture and Information ContentGertraud Burger, Université de Montréal, Montréal, QC, Canada93.2 Regulating Mitochondrial DNA Replication and TranscriptionDavid Clayton, Howard Hughes Medical Institute, Chevy Chase, MD, United States93.3 Diversity and Evolution of Mitochondrial RNA Editing SystemsMichael Gray, Dalhousie University, Halifax, NS, Canada94. Concurrent Session 30Cell Cycle RegulationThis session was made possible through an unrestricted educational grant by the Institute of Cancer Research/CIHR.Chair: Elaine Elion, Harvard Medical School, Boston, MA, United StatesCo-Chair: Dan Durocher, University of Toronto, Toronto, ON, Canada09:35–11:05, Room 520AD94.1 The Yeast Kinetochore Protein Complex and its Role in Genome StabilityPhil Hieter, University of British Columbia, Vancouver, BC, Canada94.2 Regulatory Links Between Scaffold Proteins That Regulate MAPK Cascades and the Actin CytoskeletonElaine Elion, Harvard Medical School, Boston, MA, United States94.3 Regulation of the F-box Protein Skp2 by Growth Factors and Tumor SuppressorsSylvain Meloche, Institut de Recherches Clinique de Montéal, QC, Canada95. Concurrent Session 31ApoptosisThis session was made possible through an unrestricted educational grant by the Institute of Cancer Research/CIHR.Chair: Jerry Adams, Walter and Eliza Hall Institute, Melbourne, AustraliaCo-Chair: Vincent Duronio, University of British Columbia, Vancouver, BC, Canada09:35–11:05, Room 520CF Please note: This session has been rescheduled for 14:45–16:1595.1 Life and Death Decisions at the Cellular LevelJerry Adams, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia95.2 Pathways to Granzyme-induced DeathChris Bleackley, University of Alberta, Edmonton, AB, Canada95.3 p53-dependent and -independent Apoptosis of Glioma CellsBozena Kaminska, Nencki Institute of Experimental Biology, Warsaw, Poland96. Concurrent Session 32Biochemistry and Molecular Biology of Severe Acute Respiratory Syndrome (SARS)This session was made possible through unrestricted educational grants by the Institute of Infection and Immunity/CIHR and the Office of Vice-President Research University of British Columbia.Chair: Bhagi Singh, University of Western Ontario, London, ON, CanadaCo-Chair: David Andrews, McMaster University, Hamilton, ON, Canada09:35–11:05, Room 519AB96.1 SARS Virus: A Bioinformatic AnalysisChris Upton, University of Victoria, Victoria, BC, Canada96.2 Structural Studies on Coronavirus Main Proteinases: Basis for the Design of Anti-SARS DrugsRolf Hilgenfeld, University of Luebeck, Luebeck, Germany96.3 Science During Epidemic: Lessons from SARSFrank Plummer, National Microbiology Laboratory, Winnipeg, MB, Canada97. Concurrent Session 33Mice, Protein, and MessageChair: Alexander Archakov, Institute of Biomedical Chemistry of Rams, Moscow, Russia09:35–11:05, Room 518ABC97.1 Genetic Analysis of Apoptotic PathwaysTak Mak, Princess Margaret Hospital, Toronto, ON, Canada97.2 Protein-Protein Interactions as a Target for Drugs in ProteomicsAlexander Archakov, Institute of Biomedical Chemistry of Rams, Moscow, Russia97.3 Integrating “Omic” Information: A Bridge Between Genomics and Systems BiologyMarc Vidal, Boston, MA, United States11:05 Break98. Concurrent Session 34Transcription: RNA Polymerase and Transcription FactorsChair: Mary Osborn, Max Planck Institute for Biophysical Chemistry, Goettingen, GermanyCo-Chair: Gilles Lajoie, University of Western Ontario, London, ON, Canada11:15–12:45, Room 520BE98.1 DNA Damage Signaling to the TATA Box Binding ProteinMike Schultz, University of Alberta, Edmonton, AB, Canada98.2 Regulation of FCP1P, a Phosphatase that Acts Upon RNA Polymerase II in Saccharomyces cerevisiaeCaroline Kane, University of California, Berkeley, Berkeley, CA, United States98.3 Regulation of Cell Fate by Combinational Interactions of Transcription FactorsMona Nemer, Clinical Research Institute of Montreal, Montreal, QC, Canada99. Concurrent Session 35Mammalian and Fungal PrionsChair: Roger Morris, King's College London, London, United KingdomCo-Chair: Marica Bakovic, University of Guelph, Guelph, Ontario, Canada11:15–12:45, Room 520AD99.1 Mutational Control of Amyloid Conformations: Implications for the Generation of Prion Transmission BarriersJonathan Weissman, UCSF/HHMI, San Francisco, CA, United States99.2 Structural Comparisons of the Recombinant and Natural Prion ProteinSimone Hornemann, Institute for Molecularbiology and Biophysics, Zürich, Switzerland99.3 The Changing Membrane Environment of Mouse Prion Protein and Its Influence Upon Susceptibility to Pathogenic ConversionRoger Morris, King's College London, London, United Kingdom100. Concurrent Session 36In Vivo/Whole Body Metabolism by NMR and SpectroscopyChairs: Ian Smith, Institute for Biodiagnostics, Winnipeg, MB, CanadaCo-Chair: Carolyn Mountford, Institute for Magnetic Resonance Research, St. Leonards, Australia11:15–12:45, Room 518ABC100.1 A Spetroscopic Approach to the Early Diagnosis of Colon Cancer: NMR and IRIan Smith, Institute for Biodiagnostics, Winnipeg, MB, Canada100.2 MRS Is in the Clinic and Improving Patient ManagementCarolyn Mountford, Institute for Magnetic Resonace Research, Sydney, Australia100.3 1H MR Spectroscopy and 23Na MR Imaging Correlates of Tissue Damage in Cerebral IschemiaRobert Bartha, University of Western Ontario, London, ON, Canada101. Concurrent Session 37Integration of Signalling PathwaysChair: Carlos Fernandez-Patron, University of Alberta, Edmonton, AB, CanadaCo-Chair: John Scott, Oregon Health Science University, Portland, OR, United States11:15–12:45, Room 524ABC101.1 Functional Responses to BCR-mediated Signaling Pathways Alter During B Cell DevelopmentMargaret Harnett, University of Glasgow, Glasgow, United Kingdom101.2 Signaling Through the Extracellular Signal-regulated Kinase (ERK) Cascade in Cardiac MyocytesAngela Clerk, Imperial College London, London, United Kingdom101.3 Molecular Organization of Cytoskeletal Transduction ComplexesJohn Scott, Howard Hughes Medical Institute, Portland, OR, United States102. Concurrent Session 38Proteomics: Past, Present, and the FutureChair: Samir Hanash, Human Proteome Initiative Committee, University of Michigan, Ann Arbor, MI, United States11:15–12:45, Room 519AB102.1 Opportunities for Major Initiatives in ProteomicsSamir Hanash, Human Proteome Initiative Committee, University of Michigan, Ann Arbor, MI, United States102A. Concurrent Session 38AClinical and Fundamental Advances in Proteomics102A.1 The Oxidative Stress Response, as Viewed by ProteomicsThierry Rabilloud, DRDC/BECP, CEA-Grenoble, France102A.2 The Five Dimensions of DiseaseDenis Hochstrasser, Geneva University Hospital, Geneva, Switzerland103. Concurrent Session 39Tissue to DiscoveryThis session was made possible through an unrestricted educational grant by the Ontario Genomics Institute.Chair: Jim Woodgett, University of Toronto, Toronto, ON, Canada14:45–16:15, Room 520BE103.1 Next Generation in MicrorraysJim Woodgett, University of Toronto, Toronto, ON, Canada103.2 Metabolic Profiling and Functional ProteomicsDavid Wishart, University of Alberta, Edmonton, AB, Canada103.3 Human Genome on a Chip for Stem Cell ResearchWilhelm Ansorge, EMBL, Heidelberg, GermanyPharmaceutical ProteomicsChair: Stanley Bellowski, United States103.4 Integration of Proteomics with Pathology and HistologyStanley Belkowski, United States103.5 Proteomics in Drug Discovery and DevelopmentMark Molloy, Pfizer Global Research and Development, Ann Arbor Laboratories, MI, United States104. Concurrent Session 40Regulation of Myosin II in the Actin CytoskeletonChair: Kristine Kamm, UT Southwestern Medical Center, Dallas, TX, United StatesCo-Chair: Terry Hébert, Montreal Heart Institute, Montreal, QC, Canada14:45–16:15, Room 524ABC104.1 Regulation of Myosin Light Chain Kinase In Vitro and In VivoKristine Kamm, UT Southwestern Medical Center, Dallas, TX, United States104.2 Regulation of Myosin PhosphataseDavid Hartshorne, University of Arizona, Tucson, AZ, United States104.3 Regulation of Phosphorylation of Myosin Light Chain by RhoKozo Kaibuchi, Nagoya University Graduate School of Medicine, Nagoya, Japan105. Concurrent Session 41Educational Session: NanotechnologyChair: Stephan Dahms, San Diego State University College Sciences, San Diego, CA, United States14:45–17:10, Room 514ABC105.1 Microfluidics & ProteomicsLaurell Thomas, Lund Unversity, Lund, Sweden105.2 Microfluidics and ProteomicsFred Regnier, Purdue University, IN, United States105.3 Protein Microarrays Main SessionPaul Predki, Yale University, New Haven, CT, United States105.4 Genomics as an Alternative to ProteomicsCharles Cantor, Sequenom, Inc., United States106. Oral Session 22Proteomes of Human TissuesChair: Alexey Pshezhetsky, Montreal University-Service de Génétique Médicale, Hôpital Sainte-Justine, Montréal, QC,Canada14:45–16:15, Room 518ABC14:45 106.1 Systematic Analysis of Human Fetal Liver Proteome and Integration with Its TranscriptomeFuchu He, Beijing Institute of Radiation Medicine, Beijing, P.R. China14:57 106.2 Proteomic Analysis of Human Stem Cell Plasma Membranes by Mass SpectrometryPatricia Anne-Marie Zeemann, University of Southern Denmark, Odense, Denmark15:09 106.3 Multidimensional Proteome Profiling of Human PlasmaMichael Simonian, Beckman Coulter Inc., Fullerton, CA, United States15:21 106.4 The Cerebrospinal Fluid Proteome: Quantification of the Differences Between the Ictal and Interictal States of MigraineRoger Biringer, Thermo Electron, San Jose, CA, United States15:33 106.5 Proteome Analysis of Cerebrospinal FluidsJerome Bailey, Proteomics Bioreagen, Agilent Technologies, Wilmington, United States15:45 106.6 Removal of Albumin and IgG from Serum Facilitates Proteomic AnalysisDavid Colantonio, Queen's University, Kingston, ON, Canada15:57 106.7 Human Proteomes: New Advances and ChallengesAlexey Pshezhetsky, Associate Professor, Montreal University—Service de génétique médicale, Hôpital Sainte-Justine, Montreal, QC, Canada107. Oral Session 23Medical Proteomics—Other DiseasesChair: Rafik Sekaly, University of Montreal, Montréal, QC, Canada14:45–16:15, Room 520AD14:45 107.1 Regulation of Matrix Metalloproteinases (MMPs), and Tissue Inhibitor of Metalloproteinases (TIMP) by Anti Transforming Growth Factor-B Antibodies, and in United Proteomic Analysis of Serum and Plasma by and to Proteomics National Laboratory, CA, United States15:21 Proteomic Analysis of the Protein in SARS Beijing Genomics Institute, Beijing, P.R. of the Molecular in Actin Upon and in Human University, Montréal, QC, Canada15:57 The Human Proteome and Its to the of and University of The Oral Session Montréal, QC, Canada14:45–16:15, Room Proteomic the from AB, Proteomic National of MD, United the Proteomics Analysis for the University, Montreal, QC, of Analysis on Discovery Mass Johns Hopkins Medical Baltimore, MD, United States15:45 Analysis for Proteomic Cancer Research Center, United for Discovery and of Johns Hopkins Medical Baltimore, MD, United Coffee Oral Session Montreal, QC, Room The Mouse The Laboratory, United a New for Genome Analysis of Proteomic in Yeast MA, United for of Protein University of New Concurrent Session of Sciences, Institute of Molecular and Room Structural Basis for Ontario Cancer Institute, Toronto, ON, in the the to the University of the Signaling in the Cardiac Institute of Molecular and of Sciences, Oral Session University of Michigan, Ann Arbor, Michigan, United Room The Plasma Proteome and and University of Michigan, Ann Arbor, Michigan, United in on Human Proteomic a Proteome London, United the of for Mass Analysis of a The Johns Hopkins University School of Medicine, Baltimore, MD, United and Analysis of Proteins to the Human Serum Proteome in University of Michigan, Ann Arbor, MI, United of Plasma Proteins from AB, Analysis of Human Inc., United Oral Session ProteomicsChair: David Thomas, University, Montréal, QC, Room Protein and Diagnostics by Serum to the of Hospital, Montréal, QC, of Protein to Protein-Protein Interactions and of Molecular Human Protein for Systems Johns Hopkins University, Baltimore, MD, United Human Protein in the Signalling Oral Session He, Beijing Institute of Radiation Medicine, Beijing, P.R. 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