Rheumatoid arthritis: comorbidities
Notice bibliographique
Résumé
Background: RA is a chronic inflammatory disease of the synovial joints leading to progressive joint destruction, functional impairment and, in severe cases, the need for joint replacement.There is a need to identify which of these patients are more likely to need a joint replacement in order to plan both clinically and economically for patient care.Previous research has identified several biomarkers that may be associated with inflammation and disease activity in RA.Hepatocyte growth factor (HGF) is a pleiotropic cytokine that regulates cell growth, cell motility and tissue regeneration.Expression of HGF has been reported in the synovium of patients with RA and may be associated with disease activity.The objective of our study was to investigate the association between levels of HGF and total joint replacement of the hip and knee in patients with RA.Methods: Data were collected from 412 RA patients with established disease who were followed prospectively.The mean (S.D.) age of the cohort was 61 (10.8) years with a disease duration of 11(4.8) years and 279 (67.7%) of the cohort were female.Clinical indices of disease severity were recorded including whether each patient had undergone hip or knee replacement.Of the 412 patients enrolled, 209 have reached 5 year follow-up (50.7%).Serum levels of HGF at recruitment were quantified using a fluorescent bead-based assay system (Luminex) and at the 5-year follow-up using enzyme-linked immunosorbent assays (ELISA).Associations between joint replacement and HGF levels were analysed using the Mann-Whitney U test for non-parametric data.Results: High levels of HGF were associated with joint replacement of the hip or knee at baseline and at 5-year follow-up.At baseline, significantly higher levels of serum HGF were found in patients who had previously had a hip or knee replacement (n ¼ 63) compared with patients who had not received a joint replacement: median (IQR) HGF level (1502 (665) vs 1388 (554) pg/ml, P ¼ 0.048).This association was significantly greater for knee replacement alone: median (IQR) HGF level (1610 (683) vs 1382 (548) pg/ml, P ¼ 0.016).At 5-year follow-up, serum HGF levels were significantly higher in patients who had received a new hip or knee replacement since baseline (n ¼ 33) compared with those who had not had these joints replaced: median (IQR) HGF level (1296 (1894) vs 1115 (862) pg/ml, P ¼ 0.040).Conclusion: Joint replacement of the hip or knee in patients with RA is associated with high circulating levels of HGF and may reflect a role for HGF in joint damage.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,038 | 0,009 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».