Notice bibliographique
Résumé
Background: Estrogen has been known to be involved in development and/or progression of tumor cells arising in several organs including breast, endometrium, ovary, and others. Human skin is also considered the target organs of estrogens, which play some roles in the age-related dermal changes. In primary squamous cell carcinoma (SCC) of the skin, past history of burn and irradiation have been in general considered one of the important local carcinogenetic factors. In normal skin, fibroblasts in dermis have been demonstrated to express aromatase, one of the estrogen-producing enzymes, has also been proposed based on these findings but their details remain unknown. These injuries to skin above may also be considered to result in the disruption of estrogenrelated physiological functions of the skin, which cause tumor. In this study, we therefore examined whether estrogen receptor (ER) , ER and aromatase are expressed in SCC of the skin or not. Design: Forty-eight cases (male: female 33:15, age range 44-99 yo.) with primary SCC of the skin were retrieved for imuunohistochemical study of ER, ER, aromatase and Ki67. The specimens had been all fixed in 10% formaldehyde solution and embedded in paraffin. Serial tissue sections were used for hematoxylin-eosin staining and immunohistochemistry, performed by LSAB method. Nuclear immunoreactivity for ER and ER was evaluated in 500 cancer cells, and the percentage of positive cells was subsequently obtained. Cytoplasmic immunoreactivity for armoatase with more than 10% of carcinoma cells was defined as "positive ". Ki67 labeling index was also obtained by counting 500 carcinoma cells. The statistical calculations, STATA version 7 (College Station, Texas) was used. P value under 0.05 was considered significant. Research protocols for this study were approved by Ethics Committee at University School of Medicine. Results: ER, ER and aromatase were positive in 93.75% (45/48 cases), 97.9% (47/48 cases) and 58.3% (28/48 cases), respectively. The positive rate of ER among aromatase-positive cases was significantly higher among aromatse-negative cases (p<0.05, Mann-Whitney test). The age of aromatase-positive cases was significantly younger than aromatase-negative ones (p<0.05, Mann-Whitney test). Conclusions: These results suggest that the combined expression of ER and aromatase could be related to carcinogenesis and/or progression of SCC of human skin.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».