P314. Biosimilar infliximab in inflammatory bowel diseases: first interim Results from a prospective nationwide observational cohort
Notice bibliographique
Résumé
Background: Medication use in females with IBD of child-bearing age is challenging and has to be dealt with individually. Patients are young and want to take an active role in their own management. Some tend to stop medications before or during pregnancy. However, they fail to realize that most drugs are considered low risk for congenital anomalies. Maintaining remission with medical treatment outweighs the potential risks of adverse drug effects. Stopping medications carries the risk of flair ups during pregnancy. Methods: This was a retrospective study were patients were recruited from 5 European centres. Female IBD patients were recruited and they were interviewed through a purposely designed questionnaire. Results: 233 patients were recruited (mean age 40 SD11.9). The mean age of diagnosis was 31.4 years (SD11.2). 85.5% of patients with ulcerative colitis (UC) had a Montreal classification of E2 or E3. 64.7% of Crohn's disease (CD) patients, had non-stricturing and non-penetrating disease. 4.3% were not compliant to treatment. Reasons given included, well-being, long standing remission, fear of medications, problems with employers and suppositories and enemas being uncomfortable. 15.0% thought that all medications should be stopped during pregnancy. 63.1% of patients were unsure and 12% claimed that only some medications should be stopped. 5-ASA was considered as a very safe medication by more than 99% of patients. Medications were stopped by the patient's doctor in 13.9%. This consisted of biologics stopped in the third trimester (2.7%), 5-ASA (9.4%), methotrexate (0.9%) and prednisolone (0.9%). Medications were added by the doctor in 3.9% mainly by adding 5-ASA, folic acid, azathioprine and prednisolone. Dose of steroids and 5-ASA were increased in 2.6%. There was no reported reduction in dose of medications. 1.7% stopped medications on their own accord. Reasons given included fear of harm to the baby and being in remission. 26.6% patients were uncertain if patients with IBD could breast feed. 40.8% thought that they could not breast feed. 54.5% breast fed their babies. In those who did not breastfeed, only 10.7% did not do so because of the medications that they were having. The rest did not breastfeed due to fear and misconceptions about IBD and breastfeeding. Conclusions: Unfortunately, 5-ASA is still regarded as unsafe during pregnancy by some physicians. There is still lack of awareness amongst patients about why patients should continue medications during pregnancy. More awareness is needed about breast feeding in patients with IBD.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».