Notice bibliographique
Résumé
Oliver Brady and colleagues (May, 2017)1Brady OJ Slater HC Pemberton-Ross P et al.Role of mass drug administration in elimination of Plasmodium falciparum malaria: a consensus modelling study.Lancet Glob Health. 2017; 5: e680-e687Summary Full Text Full Text PDF PubMed Scopus (69) Google Scholar collaborated with independent modelling groups and reached consensus on a few non-obvious points related to malaria elimination, one of which we find difficult to agree with. They recommend that, in areas close to elimination thresholds, mass drug administration (MDA) is most effective when conducted during the nadir of malaria transmission and prevalence. If the desired outcome of MDA is minimal transmission, the proposed timing during the dry season might be biologically plausible, but it is unlikely to result in success. Unsurprisingly, all modelling groups agree that coverage is essential for success; coverage during the malaria season is critical. MDA during the nadir of malaria transmission only works if the population does not change between administration and malaria transmission season. Under the non-ideal, real-life conditions in which MDA takes place, continued human migration over the months following MDA will reduce the effective coverage below the lower limit of 80% stated by Brady and colleagues as crucial for success. In western Cambodia, roughly a quarter of the human population changes location between the dry and rainy seasons. Our experience during MDA in west Africa was that young people return to their villages to help with planting and harvesting.2von Seidlein L Walraven G Milligan PJ et al.The effect of mass administration of sulfadoxine-pyrimethamine combined with artesunate on malaria incidence: a double-blind, community-randomized, placebo-controlled trial in The Gambia.Trans R Soc Trop Med Hyg. 2003; 97: 217-225Summary Full Text PDF PubMed Scopus (69) Google Scholar Seasonal migration is an important factor to consider during MDA plans, because high coverage of at-risk groups, such as farm and forest workers, is particularly urgent. The asymptomatic reservoir of plasmodium infections is not homogeneously distributed within villages, and foci of transmission could persist. MDA during the dry season might be the most practicable option, and all models have suggested that it has the best chance of interruption of local transmission. However, if this timing of MDA is adopted, then a strategy for the identification and treatment of subsequent migrants into the affected areas will probably be necessary. This course of action highlights the need for empirical data, which will not always support the expectations of modellers, not even multiple modelling groups. We declare no competing interests. Role of mass drug administration in elimination of Plasmodium falciparum malaria: a consensus modelling studyMass drug administration has the potential to reduce transmission for a limited time, but is not an effective replacement for existing vector control. Unless elimination is achieved, mass drug administration has to be repeated regularly for sustained effect. Full-Text PDF Open AccessModel citizen – Authors' replyTom Peto and colleagues point out, reasonably, that the effect of mass drug administration (MDA) on malaria could be affected substantially by patterns of human movement, and that our Article1 does not consider the effects of the specific patterns of movement they observed in Cambodia and west Africa. The purpose of our Article1 was to derive general results about the possible effect of MDA and to test how robust these are to the assumptions in different models, so we avoided assumptions about population movement that are specific to any particular place. Full-Text PDF Open Access
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,005 | 0,025 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,001 |
| Méta-épidémiologie (sens large) | 0,001 | 0,002 |
| Bibliométrie | 0,002 | 0,002 |
| Études des sciences et des technologies | 0,002 | 0,001 |
| Communication savante | 0,009 | 0,009 |
| Science ouverte | 0,004 | 0,007 |
| Intégrité de la recherche | 0,004 | 0,003 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,409 | 0,248 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».