464 FOCAL LASER ABLATION FOR PROSTATE CANCER FOLLOWED BY RADICAL PROSTATECTOMY –VALIDATION OF FOCAL THERAPY AND IMAGING ACCURACY
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Résumé
You have accessJournal of UrologyProstate Cancer: Localized II1 Apr 2010464 FOCAL LASER ABLATION FOR PROSTATE CANCER FOLLOWED BY RADICAL PROSTATECTOMY –VALIDATION OF FOCAL THERAPY AND IMAGING ACCURACY Uri Lindner, Nathan Lawrentschuk, Robert A. Weersink, Sean R.H. Davidson, Orit Raz, Eugen Hlasny, Deanna L. Langer, Mark R. Gertner, Theodorus Van der Kwast, Massom A. Haider, and John Trachtenberg Uri LindnerUri Lindner Kiryat Ono, Israel More articles by this author , Nathan LawrentschukNathan Lawrentschuk Toronto, Canada More articles by this author , Robert A. WeersinkRobert A. Weersink Toronto, Canada More articles by this author , Sean R.H. DavidsonSean R.H. Davidson Toronto, Canada More articles by this author , Orit RazOrit Raz Toronto, Canada More articles by this author , Eugen HlasnyEugen Hlasny Toronto, Canada More articles by this author , Deanna L. LangerDeanna L. Langer Toronto, Canada More articles by this author , Mark R. GertnerMark R. Gertner Toronto, Canada More articles by this author , Theodorus Van der KwastTheodorus Van der Kwast Toronto, Canada More articles by this author , Massom A. HaiderMassom A. Haider Toronto, Canada More articles by this author , and John TrachtenbergJohn Trachtenberg Toronto, Canada More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.537AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To evaluate the effects of focal laser ablation (FLA) on prostate cancer (PC) tissue, and to assess the accuracy of magnetic resonance imaging (MRI) in determining the ablated lesion volume by comparing to histology. METHODS Four patients with biopsy proven PC underwent FLA followed by radical prostatectomy (RP) one week later. MRI was done prior to FLA and immediately before RP. Meticulous step-sectioned, whole-mount histopathologic examination of the RP specimens was performed. Areas of necrosis were demarcated using standard hematoxylin and eosin (H&E) and immunohistochemical stains for cytokeratin 8, to assess treatment effect and for purpose of correlation against imaging findings. RESULTS The ablated areas were characterized by homogeneous coagulation necrosis, entirely lacking cytokeratin 8 expression. The median index tumor volume for ablation as calculated by MRI was 0.46cc (range 0.16-0.9cc); the median total ablated volume based on MRI was 2.7cc (range 2.5-4.5cc). The ablated area was 7.6 times the tumor volume (range 3-28x).The MRI calculated ablated volume was 1.4 times the histopathologically-calculated volume derived from H&E (range 1-1.6x,r=0.79) and 1.1 times that derived from vital staining (range 0.95-1.2x,r=0.89). The correlation between MRI findings of viable tissue between the ablation zone and the prostatic capsule and histopathology was very high (r=0.95). CONCLUSIONS FLA creates confluent ablation with no evidence of viable cells in treated regions. Post-ablation MRI is able to determine the ablation volume and the presence of viable tissue adjacent to the ablated zone. Laser energy appears suited for focal therapy for PC and should be evaluated further in well-designed clinical trials. © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e183 Peer Review Report Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Uri Lindner Kiryat Ono, Israel More articles by this author Nathan Lawrentschuk Toronto, Canada More articles by this author Robert A. Weersink Toronto, Canada More articles by this author Sean R.H. Davidson Toronto, Canada More articles by this author Orit Raz Toronto, Canada More articles by this author Eugen Hlasny Toronto, Canada More articles by this author Deanna L. Langer Toronto, Canada More articles by this author Mark R. Gertner Toronto, Canada More articles by this author Theodorus Van der Kwast Toronto, Canada More articles by this author Massom A. Haider Toronto, Canada More articles by this author John Trachtenberg Toronto, Canada More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,014 | 0,037 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,002 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,010 | 0,003 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».