<i>Cis</i> -diamminedichloroplatinum, vinblastine, and bleomycin combination chemotherapy in disseminated testicular cancer
Notice bibliographique
Résumé
No AccessJournal of Urology1 Feb 2002Cis-diamminedichloroplatinum, vinblastine, and bleomycin combination chemotherapy in disseminated testicular cancer Lawrence H. Einhorn and M.D., F.A.C.P. John DonohueM.D. Lawrence H. EinhornLawrence H. Einhorn From the Indiana University Medical Center; Indianapolis, Indiana. More articles by this author and John DonohueJohn Donohue From the Indiana University Medical Center; Indianapolis, Indiana. More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(02)80301-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Fifty patients with disseminated testicular cancer were treated with a three-drug combination consisting of cis-diamminedichloroplatinum, vinblastine, and bleomycin. Three patients were considered inevaluable due to early death. This chemotherapy regimen produced 74% complete and 26% partial remissions. Furthermore, five patients with partial remission became disease-free after surgical removal of residual disease, producing an overall 85% disease-free status. Toxicity, although significant during remission induction with cis-platinum, vinblastine, and bleomycin, was usually manageable, although there were two drug-related deaths during this period. Thirty-eight of these patients remain alive and 32 remain alive and disease-free at 6+ to 30+ months. We believe this regimen represents a major advance in the management of patients with disseminated testicular cancer. References 1. : A statistical review of malignant testicular tumors based on the experience of the Ontario Cancer Foundation Clinics, 1938–1961. Can Med Assoc J1966; 94: 889. Google Scholar 2. : Treatment and prognosis in seminoma of the testis. J Urol1968; 99: 72. Link, Google Scholar 3. : Recurrent seminoma: management of late metastases, recurrence of a second primary tumor. Am J Roentgenol Radium Ther Nucl Med1960; 83: 25. Google Scholar 4. : Effects of combined drug therapy on metastatic cancer of the testis. JAMA1960; 174: 145. Google Scholar 5. : Triple therapy in testicular tumors. Cancer1969; 24: 442. Google Scholar 6. : Chemotherapy of metastatic testis cancer-results in 154 patients. Cancer1966; 19: 1369. Google Scholar 7. : Vinblastine in the management of testicular cancer. Cancer1970; 25: 1009. Google Scholar 8. : A clinical review of bleomycin—a new antineoplastic agent. Cancer1973; 31: 903. Google Scholar 9. : Mithramycin therapy in advanced testicular neoplasms. Cancer1970; 26: 755. Google Scholar 10. : Combination chemotherapy in the treatment of advanced Hodgkin's disease. Ann Intern Med1970; 73: 881. Google Scholar 11. : Continuous intravenous bleomycin therapy with vinblastine in stage III testicular neoplasia. Cancer Chemother Rep1975; 59: 563. Google Scholar 12. : Inhibition of cell division in E. Coli by electrolysis products from a platinum electrode. Nature1965; 205: 678. Google Scholar 13. : Diaminodichloroplatinum: a phase I study showing responses in testicular and other tumors. Cancer1974; 33: 1219. Google Scholar 14. : Kinetic scheduling of vincristine (NSC-67574) and bleomycin (NSC-125066) in patients with lung cancer and other malignant tumors. Cancer Chemother Rep1973; 57: 219. Google Scholar 15. : The effects of bleomycin on survival and cell progression in Chinese hamster cells in vitro. Cancer Res1971; 31: 1218. Google Scholar 16. : Chemoimmunotherapy of adult acute leukemia. Prolongation or remission in myeloblastic leukemia with BCG. Lancet1974; 2: 1405. Google Scholar 17. : Chemoimmunotherapy of disseminated malignant melanoma with dimethyl triazeno imidazole carboxamide and bacillus Calmette-Guerin. N Engl J Med1974; 291: 592. Google Scholar 18. in press for : Bleomycin serum pharmacokinetics as determined by a radioimmunoassay and a microbiologic assay in a patient with compromised renal function. Cancer1977; . Google Scholar 19. : A chemotherapeutic approach to advanced testicular carcinoma. Can J Surg1967; 10: 421. Google Scholar 20. : Combination chemotherapy of testicular tumors. J Urol1970; 103: 619. Link, Google Scholar 21. : Combination chemotherapy of metastatic testicular germinal cell tumors and soft part sarcomas. Cancer1970; 25: 324. Google Scholar 22. : Primary combination chemotherapy (VAB III) for metastatic or unresectable germ cell tumors. Proc Am Soc Clin Oncol1976; 17: 296. Google Scholar 23. : Survival after surgery for germinal malignancies of the testis. Cancer1972; 30: 1225. Google Scholar 24. : Testis tumors: review of 125 cases at the Cleveland Clinic. Urology1975; 6: 588. Google Scholar 25. : Histologically benign teratoid metastasis of testicular embryonal carcinoma: report of five cases. Am J Clin Pathol1973; 59: 338. Google Scholar 26. : Combination radical surgery and multiple sequential chemotherapy for the treatment of advanced carcinoma of the testis (stage III). Cancer1976; 37: 20. Google Scholar 27. : Effect of the vinca alkaloids on RNA synthesis in relation to mitotic arrest. Fed Proc1968; 27: 760. Google Scholar 28. : Decrease of melting temperature and single strand scission of DNA by bleomycin in the presence of hydrogen peroxide. J Antibiol1969; 22: 624. Google Scholar 29. : Template inactivation: the mechanism of action of cis-dichlorodiammineplatinum. Proc Am Assoc Cancer Res1976; 17: 80. Google Scholar 30. : Serum alpha-fetoprotein and human chorionic gonadotropin in the diagnosis and management of non-seminomatous germ-cell testicular cancer. N Engl J Med1976; 295: 1237. Google Scholar 31. : The surgical management of testis tumors. J Urol1971; 106: 84. Link, Google Scholar 32. : Re-exploration for retroperitoneal lymph node metastases from testis tumor. J Urol1976; 115: 569. Link, Google Scholar © 2002 by American Urological Association, IncFiguresReferencesRelatedDetails Volume 167Issue 2 Part 2February 2002Page: 928-932 Advertisement Copyright & Permissions© 2002 by American Urological Association, IncMetricsAuthor Information Lawrence H. Einhorn From the Indiana University Medical Center; Indianapolis, Indiana. More articles by this author John Donohue From the Indiana University Medical Center; Indianapolis, Indiana. More articles by this author Expand All Advertisement PDF downloadLoading ...
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».