Moderated Posters: Congenital heart diseaseP374Classic-pattern dyssynchrony in adult patients with a Fontan circulationP375Outcome of pregnancy in patients with coarctation of aortaP376Diffuse myocardial fibrosis is not associated with decreased contractility: a magnetic resonance T1 mapping and feature tracking studyP377Cardiovascular abnormalities in patients with osteogenesis imperfecta: case-control studyP378Serial assessment of left ventricular systolic function by speckle tracking in patients with coarctation of the aorta undergoing stentingP379Longitudinal function and ventricular dyssynchrony are restored in children with pulmonary stenosis after percutaneous balloon pulmonary valvuloplastyP380Evaluation of the relationship between ventricular end-diastolic pressure and echocardiographic measures of cardiac function in adults with a Fontan circulationP381Right ventricular remodelling after percutaneaous pulmonary valve replacement in corrected tetralogy of Fallot with severe pulmonary regurgitation.Time matters
Notice bibliographique
Résumé
Background: Fontan palliation has contributed to a growing adult population with univentricular hearts (UVH).However, patients with UVH often suffer from progressive heart failure and arrhythmias leading to transplantation or death.Some previous studies on children have suggested the presence of dyssynchrony in different UVH morphologies.Purpose: Since cardiac resynchronization therapy (CRT) might be an effective treatment in carefully selected patients, we investigated the presence of classic-pattern dyssynchrony (CPD) and its relation to increased QRS duration and association with systolic and diastolic dysfunction.Methods: In a retrospective cross-sectional study, we investigated 101 adult patients with Fontan circulation.By post-processing a short axis and long-axis 2D images we generated strain curves that were visually assessed for the presence of early and late activated deformation, if the typical activation pattern was present patients were assigned to CPD group.Peak systolic strain, diastolic strain-rate (SR), and mean tissue velocities were automatically extracted from the strain-and displacement curves.Cardiac ultrasound images of 99 age-and gender matched control subjects were analyzed in the same way.Results: 101 patients were included at an mean age of 21, range 14-59 years and 60% were male, with differing anatomic lesions: unbalanced AV-canal (n¼19), hypoplastic left heart syndrome (n¼15), tricuspid atresia (n¼23), double inlet left ventricle (n¼21), single ventricles and others (n¼23).Eighteen of 101 Fontan-palliated patients had CPD.A high percentage (47%) of patients with unbalanced AV-canal displayed CPD, mostly with prolonged QRS, while the number of CPD in RV (9%) and LV (12%) anatomy was lower (p¼0.016),with still a significant number (18%).Only six patients out of 18 with CPD had a ventricular pacemaker with predominant ventricular pacing.Four patients with ventricular pacing showed neither CPD nor a widened QRS.CPD ventricles (n¼18), compared to other Fontan-palliated patients (n¼83) and healthy controls displayed significantly larger QRS width (143619 vs 107 616 vs 87 612 ms), lower EF (30613 vs 46613 vs 5568% p<0.05), lower early diastolic SR (0.760.5 vs1.260.8 vs 1.760.5s-1),systolic circumferential (-965 vs-1667 vs -2264%) and longitudinal strain (-865 vs -14 65 vs -196% p<0.05), respectively.Conclusion: CPD is present in a significant percentage of adults with Fontan palliation.CPD ventricles have reduced systolic and diastolic function compared to other Fontan-palliated patients.Since the presence of CPD predicts response to CRT in normal biventricular circulation, our findings might have important potential implications for prospective evaluation of CRT in this specific patient-population.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,011 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».