0254 Association of Slow Wave Activity and Odds Ratio Product with Internalizing and Externalizing Problems in Children and Adolescents
Notice bibliographique
Résumé
Abstract Introduction The association of metrics of sleep microstructure with internalizing and externalizing problems in youth has remained elusive. While one study found increased frontal slow wave activity (SWA) in depressed adolescents, there is lack of evidence for a relationship between dimensional measures of behavior and metrics of sleep depth/intensity. We examined the association between two measures of sleep depth/intensity, slow wave activity (SWA) and odds ratio product (ORP), with internalizing and externalizing problems in children and adolescents. Methods We calculated SWA and ORP during non-rapid eye movement (NREM) sleep at central, frontal and fronto-occipital derivations in 639 children (5-12y, median 9y) and 418 adolescents (12-23y, median 16y) from the Penn State Child Cohort via in-lab polysomnography. ORP provides a standardized measure of NREM sleep depth, while ORP-9 (average ORP in the 9-seconds following NREM arousals) provides a metric of arousability. SWA (0.4-4Hz) absolute power (µV2) was determined during NREM sleep. Internalizing and externalizing problems were assessed on Achenbach’s Behavior Checklist by parent (subjects≤17y) or self-report (subjects≥18y). For each scale, T-scores with a mean of 50 and standard deviation of 10 were obtained following standardized scoring. Multivariable-adjusted linear regression models examined the association between SWA/ORP and clinical outcomes. Results At ages 5-12, fronto-occipital SWA was negatively associated with externalizing behaviors (p=0.05), while fronto-occipital and frontal ORP, and frontal ORP-9 were positively associated with internalizing symptoms (all p<0.01). At ages 12-23, central SWA was negatively associated with internalizing symptoms (p=0.05), while central (p=0.05) and frontal (p=0.03) ORP and central ORP-9 (p=0.03) were positively associated with externalizing behaviors. Conclusion Reductions in SWA in childhood or adolescence are associated with developmentally appropriate behavioral problems, as depression/anxiety are more prevalent in adolescence. In contrast to SWA, increased ORP (lighter sleep) and ORP-9 (greater arousability) are associated with more anxiety/depression in childhood, yet more externalizing behaviors in adolescence. These distinct associations, such as SWA with externalizing behaviors and ORP with internalizing symptoms during childhood, may reflect how SWA captures local/synaptic control, while ORP global/state control, of sleep depth, making both sleep EEG biomarkers important from a developmental standpoint. Support (If Any) National Institutes of Health (R01MH118308, UL1TR000127)
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».