Esophagectomy postallogenic hematopoietic stem cell transplantation for hematologic malignancy: A case series

Central MessageEsophagectomy is feasible in high-risk patients following allogenic hematopoietic stem cell transplantation for hematologic malignancy.Survival rates following allogenic hematopoietic stem cell transplantation (AHSCT) for hematologic malignancies continue to improve.1Saunders I.M. Tan M. Koura D. Young R. Long-term follow-up of hematopoietic stem cell transplant survivors: a focus on screening, monitoring, and therapeutics.Pharmacotherapy. 2020; 40: 808-841Crossref PubMed Scopus (4) Google Scholar Patients undergo aggressive chemotherapy with or without radiation therapy, followed by relapse of their primary disease, leading to AHSCT. Preparation for transplantation requires intensive preconditioning with immune suppression and chemotherapy, followed by long-term immune suppression to modulate complications such as graft versus host disease (GvHD), an independent risk factor for solid-organ malignancy.1Saunders I.M. Tan M. Koura D. Young R. Long-term follow-up of hematopoietic stem cell transplant survivors: a focus on screening, monitoring, and therapeutics.Pharmacotherapy. 2020; 40: 808-841Crossref PubMed Scopus (4) Google Scholar These patients form a difficult cohort for esophagectomy due to their previous chemotherapy or radiation therapy in addition to necessary ongoing immune modulation. This series reports 3 consecutive patients, all with AHSCT and significant GvHD, developing interval esophageal squamous cell carcinoma (SCC) at varying remote intervals from their primary diagnosis and undergoing minimally invasive esophagectomy (MIE).Case SeriesOur institutional database was reviewed to identify appropriate cases. Patients provide consent for inclusion in this database and any research activity arising from it at diagnosis. Patient demographics and broad treatment approaches are outlined in Table 1. Patient 1 was initially diagnosed with chronic lymphocytic leukemia, which subsequently underwent transformation to non-Hodgkin lymphoma. Following relapse with non-Hodgkin lymphoma, he had induction therapy with busulfan and cyclophosphamide, followed by human leukocyte antigen–matched AHSCT. He had GvHD of the oral mucosa, connective tissue, and skin and 18 years following transplant was diagnosed with a T3N1 SCC due to symptomatic dysphagia. Following neoadjuvant CROSS chemoradiotherapy (41.4-Gy radiation with carboplatin and paclitaxel), he underwent an uncomplicated 2-field MIE with a 7-day hospital stay. His final histopathology showed a T2N1 tumor. He remains disease-free 3 years' postresection.Table 1Patient details for those with esophageal cancer following allogenic hematopoietic stem cell transplantationPatient 1Patient 2Patient 3SexMaleFemaleMalePrimary hematologic malignancyChronic lymphocytic leukemia with transformation to non-Hodgkin lymphoma and immune mediated thrombocytopeniaAcute lymphoblastic leukemiaAcute lymphoblastic leukemiaAge at diagnosis, y475040Primary chemotherapyCHOPDana Farber induction protocol∗Dana Farber induction protocol generally consists of doxorubicin, vincristine, dexamethasone, mercaptopurine, pegaspargase, methotrexate and subsequent intrathecal methotrexate, cytarabine, and hydrocortisone.Dana Farber induction protocol∗Dana Farber induction protocol generally consists of doxorubicin, vincristine, dexamethasone, mercaptopurine, pegaspargase, methotrexate and subsequent intrathecal methotrexate, cytarabine, and hydrocortisone.Age at hematopoietic stem cell transplant, y485044Induction regimenBusulfan and cyclophosphamideBusulfan and cyclophosphamide, TBI and whole-body irradiation with 400 cGyBusulfan, fludarabine, TBI, and whole-body irradiation with 400 cGyMaintenance immune suppressionCyclosporine and methotrexateCyclosporineNoneComplications secondary to BMTChronic GvHD, predominantly affecting skin and subcutaneous tissuesGvHD, predominantly affecting skin, oral mucosa and causing benign esophageal strictureGvHD affecting mouth, alimentary tract, liver, eyes and skin. AVN of both femoral headsInterval to diagnosis of esophageal cancer, y1846HistologyModerately differentiated SCC distal esophagusModerately differentiated SCC of distal third of esophagusInvasive moderately differentiated SCC of midesophaguscTNMcT3N1M0cT1bN0M0cT3N1M0Perioperative therapyCROSSNone, straight to surgeryCROSSOperative intervention2-field (Ivor Lewis with stapled intra-thoracic anastomosis) MIE2-field (Ivor Lewis with stapled intra-thoracic anastomosis) MIE3-field (McKeown with stapled modified Collard cervical anastomosis) MIEFinal TNMypT2N1MxpT1bN0MxypTxN0Mx (complete pathologic response)30-d morbidityNoneNoneNone30-d mortalityNoNoNoNotesPrevious whole-brain irradiation. Also has synchronous floor of mouth SCC resected at time of MIEPrevious whole-brain irradiationCHOP, Cyclophosphamide, doxorubicin, vincristine, prednisolone; TBI, total brain irradiation; BMT, bone marrow transplant; GvHD, graft versus host disease; AVN, avascular necrosis; SCC, squamous cell carcinoma; CROSS, 41.4-Gy radiation with carboplatin and paclitaxel; MIE, minimally invasive esophagectomy; TNM, tumor-node-metastasis.∗ Dana Farber induction protocol generally consists of doxorubicin, vincristine, dexamethasone, mercaptopurine, pegaspargase, methotrexate and subsequent intrathecal methotrexate, cytarabine, and hydrocortisone. Open table in a new tab Patient 2 was initially diagnosed with acute lymphoblastic leukemia (ALL) aged 50 years. Following chemotherapy, and total brain irradiation, she relapsed and underwent induction therapy with busulfan and cyclophosphamide and total body irradiation with 400 cGy and successful human leukocyte antigen–matched AHSCT. She had GvHD affecting the oral mucosa (frequent ulcers), skin, and alimentary tract, with a benign esophageal stricture requiring multiple serial dilatations over 2 years and occasional cramps. During endoscopy, she was incidentally found to have a T1bN0 SCC of the midesophagus. Staging investigations also showed an incidental floor of mouth SCC. She progressed straight to surgical resection of her dual primary pathologies. She underwent an uncomplicated 2-field MIE with a floor of mouth resection, flap reconstruction, and elective tracheostomy due to limited mouth opening with a 14-day hospital stay. Final histopathology showed a T1bN0 esophageal SCC and a T2N0 oral SCC with a close deep margin. Unfortunately, this patient developed a recurrence of her oral cancer 6 months following surgery and was treated with palliative intent.Patient 3 was diagnosed with ALL aged 40 years. He developed recurrent ALL 4 years later and underwent AHSCT. He had induction therapy with busulfan and fludarabine, total brain irradiation, and total body irradiation with 400 cGy. Following his transplant, he had significant GvHD affecting his oral mucosa with frequent ulcers, alimentary tract (nausea, cramps), skin, and liver, and developed avascular necrosis of both femoral heads. Six years posttransplant, he was diagnosed with a T3N1 SCC of the midesophagus due to symptomatic dysphagia. He underwent neoadjuvant CROSS followed by an uncomplicated 3-field MIE with an 8-day hospital stay. He made an excellent recovery, and histopathology showed a complete pathologic response. He remains disease free over 1-year postresection.CommentAlthough survival following AHSCT continues to improve, consequences include the development of solid-organ malignancy such as esophageal SCC.2Atsuta Y. Suzuki R. Yamashita T. Fukuda T. Miyamura K. Taniguchi S. et al.Continuing increased risk of oral/esophageal cancer after allogeneic hematopoietic stem cell transplantation in adults in association with chronic graft-versus-host disease.Ann Oncol. 2014; 25: 435-441Abstract Full Text Full Text PDF PubMed Scopus (68) Google Scholar,3Curtis R.E. Metayer C. Rizzo J.E. Socié G. Sobocinski K.A. Flowers M.E. et al.Impact of chronic GVHD therapy on the development of squamous-cell cancers after hematopoietic stem-cell transplantation: an international case-control study.Blood. 2005; 105: 3802-3811Crossref PubMed Scopus (238) Google Scholar Because of the chemotherapy, radiotherapy, and ongoing immune modulating therapy these patients receive for AHSCT, a role for definitive chemoradiotherapy has not been established, although it may be of use in selected cases.4Ino A. Sakanaka K. Inoo H. Ishida Y. Kanda J. Mizowaki T. Definitive radiotherapy for secondary esophageal cancer after allogenic hematopoietic stem cell transplantation.Int Cancer Conf J. 2021; 10: 201-206Crossref PubMed Google Scholar The authors feel that as the evidence base is limited, neoadjuvant therapy and resection should be the approach of choice. It is unclear if esophagogastric anastomosis in an esophagus affected by GvHD leads to greater perioperative complications, particularly a potentially devastating anastomotic leak. Kato and colleagues5Kato F. Daiko H. Kanamori J. Inamoto Y. Fukuda T. Hayashi K. et al.Esophagectomy for patients with squamous cell carcinoma of the esophagus after allogenic hematopoietic stem cell transplantation.Int J Clin Oncol. 2020; 25: 82-88Crossref PubMed Scopus (3) Google Scholar described 10 patients undergoing esophagectomy following AHSCT in a Japanese population and demonstrated a high rate of postoperative pneumonia. However, their patients received induction chemotherapy, and the majority underwent an open approach to esophagectomy. Herein, we demonstrate a series of 3 patients who underwent MIE with and without induction chemoradiotherapy without significant complication. Although our series is limited, there were no anastomotic complications.Although long-term survival is achievable after esophageal resection in this context, patients must be monitored for development of other malignancies. As GvHD is an independent risk for SCC, surveillance of the esophageal remnant and gastric conduit is warranted for these patients. Following AHSCT, patients should undergo screening for oropharyngeal and esophageal cancers. Esophagectomy is feasible in high-risk patients following allogenic hematopoietic stem cell transplantation for hematologic malignancy. Esophagectomy is feasible in high-risk patients following allogenic hematopoietic stem cell transplantation for hematologic malignancy. Survival rates following allogenic hematopoietic stem cell transplantation (AHSCT) for hematologic malignancies continue to improve.1Saunders I.M. Tan M. Koura D. Young R. Long-term follow-up of hematopoietic stem cell transplant survivors: a focus on screening, monitoring, and therapeutics.Pharmacotherapy. 2020; 40: 808-841Crossref PubMed Scopus (4) Google Scholar Patients undergo aggressive chemotherapy with or without radiation therapy, followed by relapse of their primary disease, leading to AHSCT. Preparation for transplantation requires intensive preconditioning with immune suppression and chemotherapy, followed by long-term immune suppression to modulate complications such as graft versus host disease (GvHD), an independent risk factor for solid-organ malignancy.1Saunders I.M. Tan M. Koura D. Young R. Long-term follow-up of hematopoietic stem cell transplant survivors: a focus on screening, monitoring, and therapeutics.Pharmacotherapy. 2020; 40: 808-841Crossref PubMed Scopus (4) Google Scholar These patients form a difficult cohort for esophagectomy due to their previous chemotherapy or radiation therapy in addition to necessary ongoing immune modulation. This series reports 3 consecutive patients, all with AHSCT and significant GvHD, developing interval esophageal squamous cell carcinoma (SCC) at varying remote intervals from their primary diagnosis and undergoing minimally invasive esophagectomy (MIE). Case SeriesOur institutional database was reviewed to identify appropriate cases. Patients provide consent for inclusion in this database and any research activity arising from it at diagnosis. Patient demographics and broad treatment approaches are outlined in Table 1. Patient 1 was initially diagnosed with chronic lymphocytic leukemia, which subsequently underwent transformation to non-Hodgkin lymphoma. Following relapse with non-Hodgkin lymphoma, he had induction therapy with busulfan and cyclophosphamide, followed by human leukocyte antigen–matched AHSCT. He had GvHD of the oral mucosa, connective tissue, and skin and 18 years following transplant was diagnosed with a T3N1 SCC due to symptomatic dysphagia. Following neoadjuvant CROSS chemoradiotherapy (41.4-Gy radiation with carboplatin and paclitaxel), he underwent an uncomplicated 2-field MIE with a 7-day hospital stay. His final histopathology showed a T2N1 tumor. He remains disease-free 3 years' postresection.Table 1Patient details for those with esophageal cancer following allogenic hematopoietic stem cell transplantationPatient 1Patient 2Patient 3SexMaleFemaleMalePrimary hematologic malignancyChronic lymphocytic leukemia with transformation to non-Hodgkin lymphoma and immune mediated thrombocytopeniaAcute lymphoblastic leukemiaAcute lymphoblastic leukemiaAge at diagnosis, y475040Primary chemotherapyCHOPDana Farber induction protocol∗Dana Farber induction protocol generally consists of doxorubicin, vincristine, dexamethasone, mercaptopurine, pegaspargase, methotrexate and subsequent intrathecal methotrexate, cytarabine, and hydrocortisone.Dana Farber induction protocol∗Dana Farber induction protocol generally consists of doxorubicin, vincristine, dexamethasone, mercaptopurine, pegaspargase, methotrexate and subsequent intrathecal methotrexate, cytarabine, and hydrocortisone.Age at hematopoietic stem cell transplant, y485044Induction regimenBusulfan and cyclophosphamideBusulfan and cyclophosphamide, TBI and whole-body irradiation with 400 cGyBusulfan, fludarabine, TBI, and whole-body irradiation with 400 cGyMaintenance immune suppressionCyclosporine and methotrexateCyclosporineNoneComplications secondary to BMTChronic GvHD, predominantly affecting skin and subcutaneous tissuesGvHD, predominantly affecting skin, oral mucosa and causing benign esophageal strictureGvHD affecting mouth, alimentary tract, liver, eyes and skin. AVN of both femoral headsInterval to diagnosis of esophageal cancer, y1846HistologyModerately differentiated SCC distal esophagusModerately differentiated SCC of distal third of esophagusInvasive moderately differentiated SCC of midesophaguscTNMcT3N1M0cT1bN0M0cT3N1M0Perioperative therapyCROSSNone, straight to surgeryCROSSOperative intervention2-field (Ivor Lewis with stapled intra-thoracic anastomosis) MIE2-field (Ivor Lewis with stapled intra-thoracic anastomosis) MIE3-field (McKeown with stapled modified Collard cervical anastomosis) MIEFinal TNMypT2N1MxpT1bN0MxypTxN0Mx (complete pathologic response)30-d morbidityNoneNoneNone30-d mortalityNoNoNoNotesPrevious whole-brain irradiation. Also has synchronous floor of mouth SCC resected at time of MIEPrevious whole-brain irradiationCHOP, Cyclophosphamide, doxorubicin, vincristine, prednisolone; TBI, total brain irradiation; BMT, bone marrow transplant; GvHD, graft versus host disease; AVN, avascular necrosis; SCC, squamous cell carcinoma; CROSS, 41.4-Gy radiation with carboplatin and paclitaxel; MIE, minimally invasive esophagectomy; TNM, tumor-node-metastasis.∗ Dana Farber induction protocol generally consists of doxorubicin, vincristine, dexamethasone, mercaptopurine, pegaspargase, methotrexate and subsequent intrathecal methotrexate, cytarabine, and hydrocortisone. Open table in a new tab Patient 2 was initially diagnosed with acute lymphoblastic leukemia (ALL) aged 50 years. Following chemotherapy, and total brain irradiation, she relapsed and underwent induction therapy with busulfan and cyclophosphamide and total body irradiation with 400 cGy and successful human leukocyte antigen–matched AHSCT. She had GvHD affecting the oral mucosa (frequent ulcers), skin, and alimentary tract, with a benign esophageal stricture requiring multiple serial dilatations over 2 years and occasional cramps. During endoscopy, she was incidentally found to have a T1bN0 SCC of the midesophagus. Staging investigations also showed an incidental floor of mouth SCC. She progressed straight to surgical resection of her dual primary pathologies. She underwent an uncomplicated 2-field MIE with a floor of mouth resection, flap reconstruction, and elective tracheostomy due to limited mouth opening with a 14-day hospital stay. Final histopathology showed a T1bN0 esophageal SCC and a T2N0 oral SCC with a close deep margin. Unfortunately, this patient developed a recurrence of her oral cancer 6 months following surgery and was treated with palliative intent.Patient 3 was diagnosed with ALL aged 40 years. He developed recurrent ALL 4 years later and underwent AHSCT. He had induction therapy with busulfan and fludarabine, total brain irradiation, and total body irradiation with 400 cGy. Following his transplant, he had significant GvHD affecting his oral mucosa with frequent ulcers, alimentary tract (nausea, cramps), skin, and liver, and developed avascular necrosis of both femoral heads. Six years posttransplant, he was diagnosed with a T3N1 SCC of the midesophagus due to symptomatic dysphagia. He underwent neoadjuvant CROSS followed by an uncomplicated 3-field MIE with an 8-day hospital stay. He made an excellent recovery, and histopathology showed a complete pathologic response. He remains disease free over 1-year postresection. Our institutional database was reviewed to identify appropriate cases. Patients provide consent for inclusion in this database and any research activity arising from it at diagnosis. Patient demographics and broad treatment approaches are outlined in Table 1. Patient 1 was initially diagnosed with chronic lymphocytic leukemia, which subsequently underwent transformation to non-Hodgkin lymphoma. Following relapse with non-Hodgkin lymphoma, he had induction therapy with busulfan and cyclophosphamide, followed by human leukocyte antigen–matched AHSCT. He had GvHD of the oral mucosa, connective tissue, and skin and 18 years following transplant was diagnosed with a T3N1 SCC due to symptomatic dysphagia. Following neoadjuvant CROSS chemoradiotherapy (41.4-Gy radiation with carboplatin and paclitaxel), he underwent an uncomplicated 2-field MIE with a 7-day hospital stay. His final histopathology showed a T2N1 tumor. He remains disease-free 3 years' postresection. CHOP, Cyclophosphamide, doxorubicin, vincristine, prednisolone; TBI, total brain irradiation; BMT, bone marrow transplant; GvHD, graft versus host disease; AVN, avascular necrosis; SCC, squamous cell carcinoma; CROSS, 41.4-Gy radiation with carboplatin and paclitaxel; MIE, minimally invasive esophagectomy; TNM, tumor-node-metastasis. Patient 2 was initially diagnosed with acute lymphoblastic leukemia (ALL) aged 50 years. Following chemotherapy, and total brain irradiation, she relapsed and underwent induction therapy with busulfan and cyclophosphamide and total body irradiation with 400 cGy and successful human leukocyte antigen–matched AHSCT. She had GvHD affecting the oral mucosa (frequent ulcers), skin, and alimentary tract, with a benign esophageal stricture requiring multiple serial dilatations over 2 years and occasional cramps. During endoscopy, she was incidentally found to have a T1bN0 SCC of the midesophagus. Staging investigations also showed an incidental floor of mouth SCC. She progressed straight to surgical resection of her dual primary pathologies. She underwent an uncomplicated 2-field MIE with a floor of mouth resection, flap reconstruction, and elective tracheostomy due to limited mouth opening with a 14-day hospital stay. Final histopathology showed a T1bN0 esophageal SCC and a T2N0 oral SCC with a close deep margin. Unfortunately, this patient developed a recurrence of her oral cancer 6 months following surgery and was treated with palliative intent. Patient 3 was diagnosed with ALL aged 40 years. He developed recurrent ALL 4 years later and underwent AHSCT. He had induction therapy with busulfan and fludarabine, total brain irradiation, and total body irradiation with 400 cGy. Following his transplant, he had significant GvHD affecting his oral mucosa with frequent ulcers, alimentary tract (nausea, cramps), skin, and liver, and developed avascular necrosis of both femoral heads. Six years posttransplant, he was diagnosed with a T3N1 SCC of the midesophagus due to symptomatic dysphagia. He underwent neoadjuvant CROSS followed by an uncomplicated 3-field MIE with an 8-day hospital stay. He made an excellent recovery, and histopathology showed a complete pathologic response. He remains disease free over 1-year postresection. CommentAlthough survival following AHSCT continues to improve, consequences include the development of solid-organ malignancy such as esophageal SCC.2Atsuta Y. Suzuki R. Yamashita T. Fukuda T. Miyamura K. Taniguchi S. et al.Continuing increased risk of oral/esophageal cancer after allogeneic hematopoietic stem cell transplantation in adults in association with chronic graft-versus-host disease.Ann Oncol. 2014; 25: 435-441Abstract Full Text Full Text PDF PubMed Scopus (68) Google Scholar,3Curtis R.E. Metayer C. Rizzo J.E. Socié G. Sobocinski K.A. Flowers M.E. et al.Impact of chronic GVHD therapy on the development of squamous-cell cancers after hematopoietic stem-cell transplantation: an international case-control study.Blood. 2005; 105: 3802-3811Crossref PubMed Scopus (238) Google Scholar Because of the chemotherapy, radiotherapy, and ongoing immune modulating therapy these patients receive for AHSCT, a role for definitive chemoradiotherapy has not been established, although it may be of use in selected cases.4Ino A. Sakanaka K. Inoo H. Ishida Y. Kanda J. Mizowaki T. Definitive radiotherapy for secondary esophageal cancer after allogenic hematopoietic stem cell transplantation.Int Cancer Conf J. 2021; 10: 201-206Crossref PubMed Google Scholar The authors feel that as the evidence base is limited, neoadjuvant therapy and resection should be the approach of choice. It is unclear if esophagogastric anastomosis in an esophagus affected by GvHD leads to greater perioperative complications, particularly a potentially devastating anastomotic leak. Kato and colleagues5Kato F. Daiko H. Kanamori J. Inamoto Y. Fukuda T. Hayashi K. et al.Esophagectomy for patients with squamous cell carcinoma of the esophagus after allogenic hematopoietic stem cell transplantation.Int J Clin Oncol. 2020; 25: 82-88Crossref PubMed Scopus (3) Google Scholar described 10 patients undergoing esophagectomy following AHSCT in a Japanese population and demonstrated a high rate of postoperative pneumonia. However, their patients received induction chemotherapy, and the majority underwent an open approach to esophagectomy. Herein, we demonstrate a series of 3 patients who underwent MIE with and without induction chemoradiotherapy without significant complication. Although our series is limited, there were no anastomotic complications.Although long-term survival is achievable after esophageal resection in this context, patients must be monitored for development of other malignancies. As GvHD is an independent risk for SCC, surveillance of the esophageal remnant and gastric conduit is warranted for these patients. Following AHSCT, patients should undergo screening for oropharyngeal and esophageal cancers. Although survival following AHSCT continues to improve, consequences include the development of solid-organ malignancy such as esophageal SCC.2Atsuta Y. Suzuki R. Yamashita T. Fukuda T. Miyamura K. Taniguchi S. et al.Continuing increased risk of oral/esophageal cancer after allogeneic hematopoietic stem cell transplantation in adults in association with chronic graft-versus-host disease.Ann Oncol. 2014; 25: 435-441Abstract Full Text Full Text PDF PubMed Scopus (68) Google Scholar,3Curtis R.E. Metayer C. Rizzo J.E. Socié G. Sobocinski K.A. Flowers M.E. et al.Impact of chronic GVHD therapy on the development of squamous-cell cancers after hematopoietic stem-cell transplantation: an international case-control study.Blood. 2005; 105: 3802-3811Crossref PubMed Scopus (238) Google Scholar Because of the chemotherapy, radiotherapy, and ongoing immune modulating therapy these patients receive for AHSCT, a role for definitive chemoradiotherapy has not been established, although it may be of use in selected cases.4Ino A. Sakanaka K. Inoo H. Ishida Y. Kanda J. Mizowaki T. Definitive radiotherapy for secondary esophageal cancer after allogenic hematopoietic stem cell transplantation.Int Cancer Conf J. 2021; 10: 201-206Crossref PubMed Google Scholar The authors feel that as the evidence base is limited, neoadjuvant therapy and resection should be the approach of choice. It is unclear if esophagogastric anastomosis in an esophagus affected by GvHD leads to greater perioperative complications, particularly a potentially devastating anastomotic leak. Kato and colleagues5Kato F. Daiko H. Kanamori J. Inamoto Y. Fukuda T. Hayashi K. et al.Esophagectomy for patients with squamous cell carcinoma of the esophagus after allogenic hematopoietic stem cell transplantation.Int J Clin Oncol. 2020; 25: 82-88Crossref PubMed Scopus (3) Google Scholar described 10 patients undergoing esophagectomy following AHSCT in a Japanese population and demonstrated a high rate of postoperative pneumonia. However, their patients received induction chemotherapy, and the majority underwent an open approach to esophagectomy. Herein, we demonstrate a series of 3 patients who underwent MIE with and without induction chemoradiotherapy without significant complication. Although our series is limited, there were no anastomotic complications. Although long-term survival is achievable after esophageal resection in this context, patients must be monitored for development of other malignancies. As GvHD is an independent risk for SCC, surveillance of the esophageal remnant and gastric conduit is warranted for these patients. Following AHSCT, patients should undergo screening for oropharyngeal and esophageal cancers.

Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.