P-753 Pregnancy complications and placental histology following embryo transfer with a thinner endometrium
Notice bibliographique
Résumé
Abstract Study question Our objective was to assess perinatal outcomes and placental findings following in vitro fertilization (IVF) with a thinner endometrium. Summary answer Live births following IVF with a thinner endometrium were associated with placental mediated obstetric complications and lower birthweight, yet with no differences in placental histology. What is known already A lower average birth weight and higher rate of small for gestational age infants have been demonstrated in both fresh transfer and frozen transfer cycles with thinner endometrial thicknesses. Additional adverse outcomes associated with thin endometrium included hypertensive disorders of pregnancy, placenta previa, cesarean section and overall obstetric complications. Yet, no study has explored placental histology in such cases. Study design, size, duration This was a retrospective cohort study of 1057 deliveries following IVF, between 2009 and 2017. All placentas were sent to pathology irrelevant of pregnancy complication status, per protocol at our institution. Participants/materials, setting, methods Data was from a university-affiliated tertiary hospital. Included were live singleton births after IVF, compared according to maximum endometrial thickness prior to transfer: thinner endometrium group, defined as < 9-millimeters, as compared to controls, defined as ≥ 9-millimeters. Outcomes were placental findings, including anatomic, inflammatory, vascular malperfusion and villous maturation lesions and obstetric and perinatal outcomes. Continuous and categorial variables were compared as appropriate, and logistic and linear regression analyses employed.to control for confounders. Main results and the role of chance A total 292 deliveries in the thinner endometrium group, and 765 in the control (thicker) group were compared. Maternal demographics were similar between the groups, except for main treatment indication, which was more commonly diminished reserve in patients with a thinner endometrium – 17.8% vs. 9.4%, and less commonly male factor – 27.0% vs. 35.6%, p = 0.003. Live births following fresh transfer were more common in the control group, while the thinner endometrium group was notable for a higher rate of single blastocyst transfers. When controlling for confounding effects, thinner endometrium was associated with an increased rate of obstetric complications (preterm delivery, preeclampsia, low birth weight or placental abruption) - 26.0% vs. 17.5%, p = 0.001, while placental histological examination demonstrated no differences in anatomical, inflammatory or vascular lesions. In a linear regression analysis, after adjustment for confounders, thinner endometrium was associated with lower birthweights – β -101.3 grams, 95% CI (-185.0 to -17.6 grams), p = 0.01. Limitations, reasons for caution The study was limited by sample size. Missing historical information included obstetric complications in previous deliveries, which would increase the risk of reoccurrence in subsequent pregnancies and data regarding endometrial trauma (curettage for example). Wider implications of the findings Transfer with a thinner endometrium was associated with placental mediated complications and lower birthweights, despite similar placental histology. This may result from functional placental changes throughout implantation and placentation. Preventive measures for adverse obstetric outcomes, such as Micropirin, in cases in which endometrial thicknesses are suboptimal are to be determined. Trial registration number Not applicable
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».