P-330 The immune cell population of the human fallopian tubes in health and benign pathology: a systematic review
Notice bibliographique
Résumé
Abstract Study question What is the immune cell profile of the human fallopian tube in health and in benign pathological conditions? Summary answer The fallopian tubes have a distinct population of immune cells from the innate and adaptive subsystems. Variations have been observed in several tubal pathologies. What is known already The fallopian tubes play a key role in fertility; up to 30% of infertility cases have been reported due to tubal pathologies, which have been neglected due to the success of in vitro fertilisation (IVF). The fallopian tubes have been shown to harbour immune cell populations with the involvement of both the innate and adaptive arms of the immune system that provide surveillance against several pathogens. Therefore, characterisation of this population is vital in promoting a better understanding of tubal pathogenesis, and its influence on infertility, leading to improvements in the sexual and reproductive health of women. Study design, size, duration This systematic review was conducted on the 1st November 2021 and reported in accordance to PRISMA statement, and preceded by a prospectively written protocol registered with PROSPERO (registration number: CRD42021288257). CINAHL, EMBASE and EMCARE, Scopus and PubMed databases were searched for relevant published material. All studies that concerning the immune cells of human fallopian tubes in health or benign pathology of pre-menopausal, pregnant and/or post-menopausal women that published in English language were included. Participants/materials, setting, methods The predefined search strategy identified 3767 publications. Following screening, a total of 42 studies were included and data was extracted. The findings are thematically reported based on: (1) menopausal status and/or cycle phase; (2) pathophysiology; (3) immune cell types. A risk of bias assessment was performed using Newcastle-Ottawa scale (NOS) and a modified version for case studies. Main results and the role of chance T lymphocytes, predominantly CD8+ cytotoxic T cells, represent the most abundant immune cell population within the healthy fallopian tube. B lymphocytes, macrophages, natural killer (NK) cells and dendritic cells have also been identified. The number of macrophages demonstrated a consistent and significant increase during the progesterone-dominant secretory phase compared to the proliferative phase. A similar distribution of lymphocytes was reported in tubal ectopic pregnancies to that in healthy tubes. Macrophages, dendritic cells, and natural killer (NK) cells were observed in tubal pregnancies with a significant increase in the number of CD56+ and CD3+ cells in cases of tubal rupture. Salpingitis, hydrosalpinx and endometriosis are all characterised by an increased population of macrophages in comparison to healthy fallopian tubes. Limitations, reasons for caution Some studies scored poorly on the NOS, suggesting their findings to be treated with caution. The deficiency in published research into common tubal pathologies and inconsistent findings presented between studies only allowed limited conclusions to be formulated regarding these immune cell populations. Wider implications of the findings Comprehensive knowledge of the immune cell profile of the human fallopian tubes will provide greater understanding into the pathophysiology of common tubal disorders, potentially leading to innovative treatments in the future. Trial registration number not applicable
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,004 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,003 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».