Pigmented squamous cell carcinoma in situ with amyloid deposition mimicking melanoma
Notice bibliographique
Résumé
Clinical presentationA 68-year-old female presented with an 18-months history of an incidentally noticed asymptomatic lesion on the right buttock. There was no personal or family history of skin cancer, no tanning booth use, and minimal sun exposure. On examination, there was a 12 × 5 mm brown-black plaque with irregular borders (Fig 1).Dermatoscopic appearanceContact polarized dermatoscopic examination revealed a multicomponent pattern composed of gray and brown dots and structureless zones (Fig 2).Fig 2Contact polarized dermatoscopic image showing a multicomponent pattern composed of gray and brown dots and structureless zones.View Large Image Figure ViewerDownload Hi-res image Download (PPT)Histologic diagnosisHistology demonstrated full-thickness epidermal atypia and presence of eosinophilic globules in the papillary dermis (Fig 3). A crystal violet stain was positive in some globules compatible with amyloid (Fig 4).Key messagePigmented squamous cell carcinoma in situ (SCCis) is an uncommon variant of SCCis. It most commonly presents as progressively enlarging papules/plaques, typically in photoexposed areas. Pigmented SCCis is often seen in dark skin phototypes and may clinically mimic melanoma, pigmented basal cell carcinoma, and seborrheic keratosis. Dermatoscopy may aid in diagnosis and can reveal multicomponent pattern, atypical glomerular vascular structures, absence of a pigment network or pseudonetwork, diffuse pigmentation or blotches, hypopigmented structureless areas, or brown or gray dots in a linear fashion.1Cameron A. Rosendahl C. Tschandl P. Riedl E. Kittler H. Dermatoscopy of pigmented Bowen's disease.J Am Acad Dermatol. 2010; 62: 597-604https://doi.org/10.1016/j.jaad.2009.06.008Abstract Full Text Full Text PDF PubMed Scopus (106) Google Scholar Histologically, pigmented SCCis shows full-thickness epidermal keratinocyte atypia, dyskeratosis, nuclear pleomorphism, and apoptosis. Amyloid has been observed in these cutaneous neoplasms.2Baykal C. Hurdogan O. Babuna Kobaner G. Ekinci A.P. Buyukbabani N. Secondary localized cutaneous amyloidosis is not rare in Bowen's disease and bowenoid papulosis.Turk Patoloji Derg. 2022; 38: 54-59https://doi.org/10.5146/tjpath.2021.01530Crossref PubMed Scopus (1) Google Scholar Treatment involves surgical excision, electrodessication and curettage, photodynamic therapy, and topical chemotherapeutic agents. In our case, the lesion was treated with surgical excision.Fig 3Routine histology demonstrating full-thickness epidermal atypia and eosinophilic globules in the papillary dermis (hematoxylin and eosin stain; 10× magnification).View Large Image Figure ViewerDownload Hi-res image Download (PPT)Fig 4Crystal violet stain showing amyloid deposits in the papillary dermis (20× magnification).View Large Image Figure ViewerDownload Hi-res image Download (PPT) Clinical presentationA 68-year-old female presented with an 18-months history of an incidentally noticed asymptomatic lesion on the right buttock. There was no personal or family history of skin cancer, no tanning booth use, and minimal sun exposure. On examination, there was a 12 × 5 mm brown-black plaque with irregular borders (Fig 1). A 68-year-old female presented with an 18-months history of an incidentally noticed asymptomatic lesion on the right buttock. There was no personal or family history of skin cancer, no tanning booth use, and minimal sun exposure. On examination, there was a 12 × 5 mm brown-black plaque with irregular borders (Fig 1). Dermatoscopic appearanceContact polarized dermatoscopic examination revealed a multicomponent pattern composed of gray and brown dots and structureless zones (Fig 2). Contact polarized dermatoscopic examination revealed a multicomponent pattern composed of gray and brown dots and structureless zones (Fig 2). Histologic diagnosisHistology demonstrated full-thickness epidermal atypia and presence of eosinophilic globules in the papillary dermis (Fig 3). A crystal violet stain was positive in some globules compatible with amyloid (Fig 4).Key messagePigmented squamous cell carcinoma in situ (SCCis) is an uncommon variant of SCCis. It most commonly presents as progressively enlarging papules/plaques, typically in photoexposed areas. Pigmented SCCis is often seen in dark skin phototypes and may clinically mimic melanoma, pigmented basal cell carcinoma, and seborrheic keratosis. Dermatoscopy may aid in diagnosis and can reveal multicomponent pattern, atypical glomerular vascular structures, absence of a pigment network or pseudonetwork, diffuse pigmentation or blotches, hypopigmented structureless areas, or brown or gray dots in a linear fashion.1Cameron A. Rosendahl C. Tschandl P. Riedl E. Kittler H. Dermatoscopy of pigmented Bowen's disease.J Am Acad Dermatol. 2010; 62: 597-604https://doi.org/10.1016/j.jaad.2009.06.008Abstract Full Text Full Text PDF PubMed Scopus (106) Google Scholar Histologically, pigmented SCCis shows full-thickness epidermal keratinocyte atypia, dyskeratosis, nuclear pleomorphism, and apoptosis. Amyloid has been observed in these cutaneous neoplasms.2Baykal C. Hurdogan O. Babuna Kobaner G. Ekinci A.P. Buyukbabani N. Secondary localized cutaneous amyloidosis is not rare in Bowen's disease and bowenoid papulosis.Turk Patoloji Derg. 2022; 38: 54-59https://doi.org/10.5146/tjpath.2021.01530Crossref PubMed Scopus (1) Google Scholar Treatment involves surgical excision, electrodessication and curettage, photodynamic therapy, and topical chemotherapeutic agents. In our case, the lesion was treated with surgical excision.Fig 4Crystal violet stain showing amyloid deposits in the papillary dermis (20× magnification).View Large Image Figure ViewerDownload Hi-res image Download (PPT) Histology demonstrated full-thickness epidermal atypia and presence of eosinophilic globules in the papillary dermis (Fig 3). A crystal violet stain was positive in some globules compatible with amyloid (Fig 4).Key messagePigmented squamous cell carcinoma in situ (SCCis) is an uncommon variant of SCCis. It most commonly presents as progressively enlarging papules/plaques, typically in photoexposed areas. Pigmented SCCis is often seen in dark skin phototypes and may clinically mimic melanoma, pigmented basal cell carcinoma, and seborrheic keratosis. Dermatoscopy may aid in diagnosis and can reveal multicomponent pattern, atypical glomerular vascular structures, absence of a pigment network or pseudonetwork, diffuse pigmentation or blotches, hypopigmented structureless areas, or brown or gray dots in a linear fashion.1Cameron A. Rosendahl C. Tschandl P. Riedl E. Kittler H. Dermatoscopy of pigmented Bowen's disease.J Am Acad Dermatol. 2010; 62: 597-604https://doi.org/10.1016/j.jaad.2009.06.008Abstract Full Text Full Text PDF PubMed Scopus (106) Google Scholar Histologically, pigmented SCCis shows full-thickness epidermal keratinocyte atypia, dyskeratosis, nuclear pleomorphism, and apoptosis. Amyloid has been observed in these cutaneous neoplasms.2Baykal C. Hurdogan O. Babuna Kobaner G. Ekinci A.P. Buyukbabani N. Secondary localized cutaneous amyloidosis is not rare in Bowen's disease and bowenoid papulosis.Turk Patoloji Derg. 2022; 38: 54-59https://doi.org/10.5146/tjpath.2021.01530Crossref PubMed Scopus (1) Google Scholar Treatment involves surgical excision, electrodessication and curettage, photodynamic therapy, and topical chemotherapeutic agents. In our case, the lesion was treated with surgical excision. Pigmented squamous cell carcinoma in situ (SCCis) is an uncommon variant of SCCis. It most commonly presents as progressively enlarging papules/plaques, typically in photoexposed areas. Pigmented SCCis is often seen in dark skin phototypes and may clinically mimic melanoma, pigmented basal cell carcinoma, and seborrheic keratosis. Dermatoscopy may aid in diagnosis and can reveal multicomponent pattern, atypical glomerular vascular structures, absence of a pigment network or pseudonetwork, diffuse pigmentation or blotches, hypopigmented structureless areas, or brown or gray dots in a linear fashion.1Cameron A. Rosendahl C. Tschandl P. Riedl E. Kittler H. Dermatoscopy of pigmented Bowen's disease.J Am Acad Dermatol. 2010; 62: 597-604https://doi.org/10.1016/j.jaad.2009.06.008Abstract Full Text Full Text PDF PubMed Scopus (106) Google Scholar Histologically, pigmented SCCis shows full-thickness epidermal keratinocyte atypia, dyskeratosis, nuclear pleomorphism, and apoptosis. Amyloid has been observed in these cutaneous neoplasms.2Baykal C. Hurdogan O. Babuna Kobaner G. Ekinci A.P. Buyukbabani N. Secondary localized cutaneous amyloidosis is not rare in Bowen's disease and bowenoid papulosis.Turk Patoloji Derg. 2022; 38: 54-59https://doi.org/10.5146/tjpath.2021.01530Crossref PubMed Scopus (1) Google Scholar Treatment involves surgical excision, electrodessication and curettage, photodynamic therapy, and topical chemotherapeutic agents. In our case, the lesion was treated with surgical excision. Pigmented squamous cell carcinoma in situ (SCCis) is an uncommon variant of SCCis. It most commonly presents as progressively enlarging papules/plaques, typically in photoexposed areas. Pigmented SCCis is often seen in dark skin phototypes and may clinically mimic melanoma, pigmented basal cell carcinoma, and seborrheic keratosis. Dermatoscopy may aid in diagnosis and can reveal multicomponent pattern, atypical glomerular vascular structures, absence of a pigment network or pseudonetwork, diffuse pigmentation or blotches, hypopigmented structureless areas, or brown or gray dots in a linear fashion.1Cameron A. Rosendahl C. Tschandl P. Riedl E. Kittler H. Dermatoscopy of pigmented Bowen's disease.J Am Acad Dermatol. 2010; 62: 597-604https://doi.org/10.1016/j.jaad.2009.06.008Abstract Full Text Full Text PDF PubMed Scopus (106) Google Scholar Histologically, pigmented SCCis shows full-thickness epidermal keratinocyte atypia, dyskeratosis, nuclear pleomorphism, and apoptosis. Amyloid has been observed in these cutaneous neoplasms.2Baykal C. Hurdogan O. Babuna Kobaner G. Ekinci A.P. Buyukbabani N. Secondary localized cutaneous amyloidosis is not rare in Bowen's disease and bowenoid papulosis.Turk Patoloji Derg. 2022; 38: 54-59https://doi.org/10.5146/tjpath.2021.01530Crossref PubMed Scopus (1) Google Scholar Treatment involves surgical excision, electrodessication and curettage, photodynamic therapy, and topical chemotherapeutic agents. In our case, the lesion was treated with surgical excision. None disclosed.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».