P38 Feasibility of detection and quantification of post ICU syndrome in a cohort of cirrhosis patients
Notice bibliographique
Résumé
<h3>Background and Aims</h3> Cirrhosis accounts for 3 to 4.5% of admissions to the Intensive Care Unit (ICU) and modern advances in ICU care have improved survival. Prolonged ICU stays are associated with physical and psychological sequelae like post -traumatic stress disorder, anxiety, depression and sexual dysfunction. Post intensive care syndrome (PICS) affects patients and families, and is associated with increased healthcare costs. Hitherto, the prevalence and severity of PICS in cirrhosis has not been investigated. This pilot study aims to determine its prevalence and the feasibility of using common psychological measures in its assessment. <h3>Method</h3> We identified patients with cirrhosis admitted to ICU for organ support from 2017 to 2021. Non-cirrhotic controls were randomly selected for the same period. Demographic data, aetiology and severity of cirrhosis, reason for ITU admission, mechanical ventilation duration, previous psychological morbidity, dependency and sedation details were recorded. Validated questionnaires [Pittsburgh Sleep Quality Index (PSQI), Montreal Cognitive Assessment (MOCA), Patient Health Questionnaire (PHQ-9), Impact of Events Scale, Generalized Anxiety Disorder 7 (GAD-7), and sexual dysfunction questionnaire] were used to assess for features of PICS in a post-ICU survival clinic or following contact by investigators. Mann-Whitney U test was used to detect statistical significance. <h3>Results</h3> 36 chronic liver disease patients were screened for eligibility. 6 patients had died at the time of recruitment, 8 did not require organ support and 2 did not have a definitive diagnosis of cirrhosis and were excluded. 3 patients could not be contacted. 17 were included in the study. Controls were selected from an existing database of ICU patients. Mean age was 52 years in the cirrhosis group and 47 in controls. Aetiology of cirrhosis was alcohol in 70.6%, non-alcoholic fatty liver disease in 11.8%, autoimmune in 5.9% and cryptogenic in 5.9%. Mean MELD was 19 and mean ACLF score was 48. The mean intubation period was 13 days in the cirrhosis group and 23 in controls. 64.7% of the cirrhosis patients were sedated with propofol and fentanyl compared to 47.1% of controls. 35.3% of patients in cirrhosis group had a psychiatric background versus 17.6% of controls. 47.1% of cirrhosis patients required psychological support after ICU admission versus 35.29% of control. 5 of 6 psychological morbidity scores were numerically higher in the cirrhosis cohort, however statistical difference was not detected (see table 1). <h3>Conclusion</h3> We identified an increased need for psychiatric support post-ICU in cirrhosis patients compared to controls, though in this pilot study significant differences in morbidity was not detected through questionnaire returns. This signal requires further study in larger cohorts.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».