Exploring the Therapeutic Opportunities of the Tumour Microenvironment in Treating Pancreatic Ductal Adenocarcinoma: A Literature Review
Notice bibliographique
Résumé
Introduction: Pancreatic ductal adenocarcinoma (PDA) is an invasive cancer of the exocrine pancreas with a 5-year survival rate (<8%), highlighting the need for new therapies to increase patient survivability and remission rates. Current treatment options with chemotherapeutics have yielded minimal success, warranting further research into targeting alternative pathways in tumour progression. The complex tumour microenvironment (TME) of PDA contributes significantly to tumorigenesis and may contain promising novel targets. The therapeutic potential of some known TME elements will be explored, namely hypoxia, MMPs, and TGF-β. These options each have their merits and differences, which are crucial to evaluate and assess the trajectory of PDA research in the future. Methods: A literature review was performed to summarize all available research on the different current therapeutic options and TME components that can be utilized for PDA treatment. The terms "hypoxia," "MMPs," and "TGF- β'' were used as keywords to search databases including Medline, Embase, and CINAHL. These were searched in combination with terms relevant to PDA and TME. Studies that were peer-reviewed and written in English were taken into consideration, with a focus on those that were published between 2017 and 2022. Results: Each TME element of hypoxia, MMPs, and TGF-β have specific distinctive targets of HIF-1α, TIMP-1, and SMAD-independent pathways, respectively. These present varying mechanisms of action which differ in their efficacies and limitations. Several of these therapies are currently undergoing clinical trials to better understand the role of each inhibitor. Discussion: This literature review provides insight into the current and future treatments for PDA. Exploiting the TME to develop therapeutic interventions presents a promising strategy to inhibit disease progression, yet research done in PDA is still preliminary due to the disease complexity, but it is moving towards a clinical settings. Conclusion: Accumulating evidence has suggested that several opportunities for targeted therapy in the PDA TME are very promising and not yet thoroughly investigated. This review aids in accessibility by summarizing important information regarding PDA and the necessary further research into targeting the TME to develop a novel therapeutic treatment.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,014 | 0,003 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,002 | 0,000 |
| Bibliométrie | 0,001 | 0,004 |
| Études des sciences et des technologies | 0,001 | 0,006 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,008 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».