Tasipimidine, a novel orally administered alpha-2 adrenoceptor agonist, alleviates canine acute anxiety associated with owner departure—A pilot study
Notice bibliographique
Résumé
Separation anxiety in dogs is a problematic behavior characterized by anxiety that occurs exclusively in the owner's absence or virtual absence, resulting in owner complaints of destructiveness, excessive vocalization, and elimination in the home. The consequences of separation anxiety may include that the owners surrender their dog to a shelter, or even have the dog euthanized. Adrenergic alpha-2 agonists have been shown to be effective in alleviating acute canine fear-based behavior problems at subsedative doses. In this study, the objective was to assess the efficacy of tasipimidine, a novel orally administered adrenergic alpha-2 agonist, in alleviating acute anxiety associated with owner departure in dogs. Twelve clinically healthy privately-owned dogs with a history of separation anxiety were enrolled in a double-blind, placebo-controlled, crossover clinical field study consisting of three 4-day treatment periods in randomized order each followed by a 3-day washout. In each treatment period a different treatment was administered. The three treatments were: placebo, tasipidimine 10ug/kg and tasipidimine 30 ug/kg, all prepared as an oral solution using the same base. At each of the 4-day treatment period study treatment was administered once daily one hour before owner´s departure. Effects of treatment on signs of separation anxiety were assessed by the owner using video recordings. Owner departure related acute anxiety severity score, dog's alertness, usability of the product and adverse events were recorded. Overall, the results showed a statistically significant treatment effect favoring tasipimidine ( P = 0.001). When the doses were separately compared to placebo, the dog owners rated the effect of the study treatment more often positively after administering tasipimidine 30 µg/kg compared to placebo (OR 5.40; 95% CI 1.15-25.2; P = 0.032). A statistically significant reduction with the 30 µg/kg dose was seen in destructive/rearranging behavior ( P = 0.006) and vocalization ( P = 0.036). Most of the dogs were scored to be fully responsive at all time points (66.7%) and able to stand up and walk normally (91.7%), and none of the dogs was scored to be unresponsive or unable to walk. No serious adverse events were reported. The majority of the owners found the product very easy (75.0%) or easy (15.7%) to use. This was a small, cross-over study with one target to select the clinically most suitable dose. Tasipimidine should be further studied in a larger parallel group study to further evaluate its effect as a treatment option for dogs suffering from separation anxiety.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».