586. Systematic Literature Review of the 13-valent Pneumococcal Conjugate Vaccine (PCV13) Effectiveness Against Invasive Pneumococcal Disease in Children Globally
Notice bibliographique
Résumé
Abstract Background After a decade of 13-valent pneumococcal conjugate vaccine (PCV13) use in children, many observational studies have evaluated PCV13 vaccine effectiveness (VE) in various epidemiologic and geographic settings. The objective of this study was to systematically review the global evidence on VE of PCV13 against IPD in children. Methods A systematic literature review using Cochrane methods was conducted in November 2021 to evaluate PCV13 VE against vaccine-type and serotype-specific IPD in children. A search of Medline, Embase, the Cochrane Library (CENTRAL and CDSR), and 5 key conferences (2019-2021) was conducted, and eligible English-language articles were abstracted. Results 15 studies on PCV13 VE were included, primarily from Europe (n=7) and North America (n=3) as well as Africa (n=2), Australasia (n=2), and Asia (n=1). 11 reported VE in children who completed the full vaccination schedule [3+1 (n=3), 2+1 (n=4), 3+0 (n=3), and mixed 3+1 or 2+1 schedules (n=1)] (Table 1). 4 studies did not report VE after the complete vaccination schedule. 8 studies reported PCV13-type VE, 3 reported PCV7-type VE, and 6 reported PCV13 non-PCV7 VE. PCV13-type VE was 90 and 91% in studies using a 3+1 schedule (n=2), 76% and 79% in studies using a 2+1 schedule (n=2) and ranged from 59% to 94% in a 3+0 schedule (n=3), with variability by study design and age range (Table 1). One study reported 100% PCV13-type VE in Spain where mixed 3+1 and 2+1 schedules were used. All PCV13-type VE results were statistically significant except two outcomes restricted to children 12-24 month of age from a single study in Australia. High VE was reported against PCV13 non-PCV7 serotype IPD for fully vaccinated children across all schedules, ranging from 60% to 100% (n=6). PCV13 was effective against the shared PCV7 serotypes, ranging from 75% to 83% (n=3). Conclusion Children fully vaccinated with PCV13 have a high level of direct protection against vaccine-type IPD, irrespective of geographic variation. PCV13 VE against the shared PCV7 serotypes remained high and PCV13 VE was also high for the 6 additional PCV13-non PCV7 serotypes. PCV13 VE tended to be higher in 3+1 schedules and additional analyses by dosing schedule are needed. Disclosures Johnna Perdrizet, MPH, Pfizer Inc: Employee|Pfizer Inc: Stocks/Bonds Iwona Pustulka, MSc, Pfizer Inc.: I'm an employee of Evidera who have been paid by Pfizer Inc. to conduct an SLR which results are presented in the abstract Carol A. Forbes, PhD, Evidera (part of Thermo Fisher Scientific): Employee|Pfizer Inc: I am an employee of Evidera (part of Thermo Fisher Scientific)who have been paid by Pfizer Inc. to carry out the work reported in this abstract|Thermo Fisher Scientific: Stocks/Bonds Emily Horn, MSc, Pfizer Inc: Employee Bradford D. Gessner, M.D., M.P.H., Pfizer Inc.: Employee|Pfizer Inc.: Stocks/Bonds Kyla hayford, PhD, Pfizer Vaccines: Employed|Pfizer Vaccines: Stocks/Bonds.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,000 | 0,002 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».