Retinal tissue oxygenation differs between eye fundus regions, but not with age, sex, and intraocular pressure in non‐human primates
Notice bibliographique
Résumé
Abstract Purpose: Oxygen plays a central role in multiple physiological and pathophysiological processes, and retinal oxygen supply has been found to be an important factor in many ocular diseases. Animal models are often used to study the pathophysiological mechanisms of diseases, especially non‐human primates (NHP) due to their great similarities with humans. Few data are available on the quantification of oxygen in the retina of NHP. The objectives of the study were to establish NHP tissue oxygen saturation (StO 2 ) normative values in different eye fundus regions, compare StO 2 in these regions and analyse how StO 2 correlates to age, sex and intraocular pressure (IOP). Methods: 44 vervet monkeys (28 males/16 females, 5–28 years old) were included in the study. IOP was measured in both eyes with an ocular tonometer. StO 2 was measured in both eyes using the Zilia Ocular oximeter in the temporal (tONH) and nasal (nONH) optic nerve head, the peripapillary region (pPL) and the perifovea (pFV). T ‐tests were used to compare between regions (paired), between both eyes (paired) and between sexes (independent). Kendall's tau was used to assess the correlation between StO 2 and age, as well as that between StO 2 and IOP. Results: Mean StO 2 was 55.7% ± 4.3% in the tONH, 55.0% ± 3.9% in the nONH, 63.9% ± 7.3% in the pPL and 74.2% ± 3.4% in the pFV. No significant difference in StO 2 was observed between the left and the right eyes, just as no significant difference was observed between tONH and nONH. The StO 2 was lower in tONH and nONH than in pPL ( p = 0.0226 and 0.0060, respectively). No correlation was found between StO 2 and age, StO 2 and sex, or StO 2 and IOP. Conclusions: StO 2 in the retinal tissue of NHP has been assessed for the first time. Regional variations similar to previous human studies were observed. The results of this study show the applicability of the Zilia Ocular on NHP and provide normative values that can serve as a basis for future studies.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».