Obituary for Dr. John C. Steele (1934–2022)

John C. Steele, who has died at the age of 87, was a neurologist who was devoted to attending his patients and to describing and understanding the causes of their maladies.He will be best remembered by his colleagues for his contribution of the seminal description of progressive supranuclear palsy (PSP) and his later investigation of the parkinsonismdementia/amyotrophic lateral sclerosis (ALS) complex (lytico-bodig) of Guam.He was born in 1934 in Toronto into a medical family, and he studied medicine at the University of Toronto from 1952 to 1960.He then trained in medicine, neurology, and neuropathology in Toronto from 1960 to 1966.During his residency at Sunnybrook Hospital, he looked after a 62-year-old Ukrainian veteran with progressive gait unsteadiness and a vertical gaze palsy who died in December 1960. 1 Neuropathological examination at the Banting Institute identified widespread neurofibrillary degeneration, which was initially diagnosed as postencephalitic parkinsonism.J. Clifford Richardson, attending physician and later head of neurology, had identified his first patient with this as yet unclassified disorder in 1955, and after Jerzy Olszewski reviewed the pathology of seven similar cases, the trio concluded that this was a distinct "new" clinicopathological entity.In retrospect, the disorder had probably been reported a few times previously in the literature, but it had not yet been defined as a discrete syndrome.Richardson presented the cases at the June 1963 meeting of the American Neurological Association, following which the neuropathologist Asao Hirano stood up and drew attention to the clinical and pathological similarities of the disorder and the parkinsonism dementia complex of Guam.Dr. Steele led the writing up of the nine cases published in April 1964 in Archives of Neurology, and subsequently suggested in a single-author paper published in Brain in 1972 that PSP was in fact a relatively common condition.[2][3][4] Steele-Richardson-Olszewski syndrome was a popular alternative label for the disease for many years, but the classical presentation later came to be known as Richardson's syndrome, a change in nomenclature strongly supported by Steele.After his neurology training in Canada, Steele spent time at National Hospital Queen Square working with Dr. Denis Williams and then studied clinical neurophysiology in Marseille in 1966-1967; he spent a further period of training at the Prasat Neurological Hospital in Bangkok.He then returned to Toronto, where he worked as a pediatric neurologist at the Hospital for Sick Children, Toronto, publishing on migraine, ------------------

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