Midlife and current physical activity is associated with functional brain connectivity in older age
Notice bibliographique
Résumé
Abstract Background Previous studies have shown a physically active lifestyle in both midlife and later life to benefit cognition and brain health in older age. However, exploring the influence of physical activity engagement on functional brain connectivity is needed to fully understand the neural mechanism underlying the effect of physical engagement. Additionally, in order to give lifestyle advice to different age groups, it is important to understand the unique contributions of physical activity at different life stages, which has rarely been examined. Method The current study investigated the effect of self‐reported midlife and current physical activity engagement on functional connectivity among 105 cognitively high functioning older adults (age = 66.6±4.1). Self‐reported midlife and current moderate‐to‐vigorous physical activity (MVPA) were recorded using the Lifetime Total Physical Activity Questionnaire. We included covariates in all analyses (i.e., age, sex, years of education, socioeconomic status, genetic risk of Alzheimer’s disease (i.e., APOE ε4 carrier status). Five regions of interest (ROIs) were selected based on previous literature on the relationship between exercise and brain health which included: prefrontal (i.e., bilateral superior frontal, middle frontal, and pars opercularis of the inferior frontal gyrus), and bilateral hippocampus. Result Results showed that people who were active in midlife had greater functional connectivity between middle frontal gyrus and superior parietal region, postcentral gyrus (Voxel p <0.005, Cluster p <0.05 FDR corrected; figure 1a) than people who were relatively inactive in midlife. This effect stayed the same after controlling for current MVPA time. Secondly, the results showed that people who were active currently have greater functional connectivity between hippocampus and frontal pole (Voxel p <0.005, Cluster p <0.05 FDR corrected; figure 1b). Currently active participants also showed greater functional connectivity between pars triangularis of the inferior frontal gyrus, and bilateral middle temporal region, and frontal pole (Voxel p <0.001, Cluster p <0.05 FDR corrected; figure1c) compared to currently inactive participants, which stayed consistent after controlling for midlife MVPA time. Conclusion As a conclusion, although midlife and current MVPA time were positively associated with each other, they both influence brain functional connectivity in later life independently. The results emphasize the importance of keeping a physically active lifestyle across midlife and into later life.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».