S1040 Relationship Between Health-Related Quality of Life and Work Productivity in Patients With Ulcerative Colitis in the Tofacitinib OCTAVE Phase 3 Induction and Maintenance Studies
Notice bibliographique
Résumé
Introduction: Tofacitinib is an oral small molecule JAK inhibitor for the treatment of UC. Tofacitinib induction treatment has been shown to improve work productivity in patients (pts) with UC. However, the relationship between health-related quality of life (HRQoL) and work productivity in the tofacitinib OCTAVE clinical program has not been described. Methods: We aimed to evaluate the relationship between Inflammatory Bowel Disease Questionnaire (IBDQ) domains and Work Productivity and Activity Impairment-Ulcerative Colitis (WPAI-UC) components among pts in Phase 3 studies evaluating tofacitinib as induction or maintenance therapy for UC (OCTAVE Induction 1&2 [NCT01465763; NCT01458951]; OCTAVE Sustain [NCT01458574]). Relationships between IBDQ (total and domain scores) and WPAI-UC components (absenteeism, presenteeism, productivity loss, and activity impairment) were estimated using a repeated measures longitudinal model in which IBDQ domain score was a continuous anchor and WPAI-UC component score was the outcome (i.e., a linear relationship was imposed between the outcome and anchor). In sensitivity analyses, IBDQ domain score was used as a categorical anchor to assess the linearity assumption (which did not impose any functional relationship between outcome and anchor). Productivity loss includes absenteeism and presenteeism and thus is the most comprehensive WPAI-UC component. Analyses used all available pooled data from pts receiving tofacitinib or placebo. Results: Relationships between IBDQ total score and WPAI-UC components were very similar when using the IBDQ total score as a continuous anchor, compared with a categorical anchor, supporting the linearity assumption. The relationship between IBDQ total score and productivity loss was robust, with IBDQ total scores of 224 and 32 (higher score = better HRQoL) corresponding to a 5.6% (95% CI 3.4, 7.8) and 100.7% (97.3, 104.1) impact, respectively (Table). For every 16-point increase in IBDQ total score, productivity loss (0–100%) improved by 7.9% (7.5, 8.4; Table). Similar trends were observed between IBDQ total score and activity impairment and presenteeism; the relationship with absenteeism was weak. Similar relationships were observed between IBDQ domains and WPAI-UC components. Conclusion: In induction and maintenance studies, robust relationships between IBDQ (total and domain scores) and productivity loss were observed. These post hoc clinical trial data may not be fully generalizable to clinical practice. Table 1. - Percentage of productivity loss at IBDQ total scores in patients with UC in OCTAVE Phase 3 induction and maintenance studies (main model with IBDQ total score as a continuous anchor) Productivity loss, least squares mean, % (95% CI) IBDQ total score 32 100.7 (97.3, 104.1) 40 96.8 (93.6, 99.9) 60 86.9 (84.2, 89.5) 80 76.9 (74.7, 79.2) 100 67.0 (65.3, 68.8) 120 57.1 (55.7, 58.5) 140 47.2 (46.1, 48.4) 160 37.3 (36.2, 38.4) 180 27.4 (26.1, 28.8) 200 17.5 (15.8, 19.2) 220 7.6 (5.5, 9.7) 224 5.6 (3.4, 7.8) Point decrease in IBDQ total score 1 0.5 (0.5, 05) 16 7.9 (7.5, 8.4) The WPAI-UC is a self-administered six-item survey that generates four metrics: absenteeism (work time missed), presenteeism (impairment whilst working), productivity loss (overall work impairment from the combination of absenteeism and presenteeism), and activity impairment (non-work activity impairment). WPAI component scores are expressed as percentages, with a higher percentage indicating greater impairment and less productivityThe IBDQ evaluates disease-related quality of life by 32 items over four domains: bowel (total domain score ranges from 10 to 70), emotional (total domain score ranges from 12 to 84), social (total domain score ranges from 5 to 35), and systemic (total domain score ranges from 5 to 35). For the total score (ranges from 32 to 224) and each domain, a higher score indicates a better quality of lifeCI, confidence interval; IBDQ, Inflammatory Bowel Disease Questionnaire; UC, ulcerative colitis; WPAI-UC, Work Productivity and Activity Impairment-Ulcerative Colitis
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,006 | 0,007 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,003 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,007 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».