Ultrasound investigation of the brachial artery diameter as a non-invasive method for exposure of endothelial dysfunction in patients with ischemic heart disease and concomitant gastroesophageal reflux disease
Notice bibliographique
Résumé
Objective — to assess endothelial dysfunction in patients with ischemic heart disease (IHD) with concomitant gastroesophageal reflux disease (GERD) with the use of high-quality ultrasound imaging of the brachial artery.Materials and methods. The study involved 100 patients, who were divided into two groups. The first group included 60 patients (43 male (71.7 %), 17 female (28.3 %)) aged 42 to 60 years (the mean age 53.79 ± 3.9 years) with IHD and concomitant nonerosive form of GERD. Second group included 40 patients (28 (70 %) male, 12 (30 %) female) aged 39 to 60 years (the mean age 53.0 ± 4.6 years) with IHD without comorbidites. The control group consisted of 20 healthy participants with matching age (mean 47 ± 6.1 years old) and gender (7 (35 %) male, 13 (65 %) female). The IHD diagnosis was established according to ICD-10, Unified clinical protocol for primary, secondary and tertiary care «Stable ischemic heart disease», 2013 European Society of Cardiology guidelines on the management of stable coronary artery disease. The GERD diagnosis was made according to ICD-10 and The Montreal definition and classification of gastroesophageal reflux disease (2006). BP was measured by the Scipione Riva-Rocci/Korotkoff method using Microlife BP AG1 — 20 sphygmomanometer (Switzerland) after 10 minutes rest in sitting and supine positions to measure systolic BP. Measurements of endothelial dysfunction were conducted using reactive hyperemia test and nitroglycerine test. Brachial artery (BA) diameter measurement was conducted on Aloka-SSD-650 ultrasound scanner (Japan) using high-definition linear probe. All collected data were entered into the electronic database. Statistical processing was performed with variation and nonparametric biomedical statistics using Excel for Windows, Statistica 6.0 and SPSS Statistics statistical software. Statistical significance was determined using Student’s t-test and Wilcoxon signed-rank test. The difference in results was considered statistically significant with p-value < 0.05.Results. The obtained results showed a significant difference in BA diameter measurements between both groups of patients and control group. At the same time, the difference in BA diameter measurements between first and second study groups was not significant, while difference in BA diameter measurements between second study group and control group was significant. After conducting reactive hyperemia tests, the significantly decreased rate of BA diameter increase (p < 0.001) was noted in patients with IHD with concomitant GERD, both compared to control group and patients with IHD without comorbidities. After sublingual nitroglycerine, the significantly (p < 0.001) increased rate of BA diameter increase was defined in all study groups, evidencing the probe adequacy.Conclusions. The non-invasive high-quality ultrasound Doppler scan method to determine brachial artery dilatation during occlusion test can be used to evaluate degree of endothelial dysfunction both in people with cardiovascular diseases and people with other pathologies with underlying abnormal endothelial function.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,003 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».