Subureteral Polydimethylsiloxane Injection Versus Extravesical Reimplantation For Primary Low Grade Vesicoureteral Reflux in Children: A Comparative Study

No AccessJournal of UrologyPEDIATRIC UROLOGY1 Jan 2003Subureteral Polydimethylsiloxane Injection Versus Extravesical Reimplantation For Primary Low Grade Vesicoureteral Reflux in Children: A Comparative Study HAMDY ABOUTALEB, STÉPHANE BOLDUC, JYOTI UPADHYAY, WALID FARHAT, DARIUS J. BÄGLI, and ANTOINE E. KHOURY HAMDY ABOUTALEBHAMDY ABOUTALEB , STÉPHANE BOLDUCSTÉPHANE BOLDUC , JYOTI UPADHYAYJYOTI UPADHYAY , WALID FARHATWALID FARHAT , DARIUS J. BÄGLIDARIUS J. BÄGLI , and ANTOINE E. KHOURYANTOINE E. KHOURY View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)64114-6AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We compare the outcome of extravesical ureteral reimplantation to endoscopic polydimethylsiloxane (Macroplastique, Uroplasty, Inc., Minneapolis, Minnesota) subureteral injection for primary low grade vesicoureteral reflux in children. Materials and Methods: Between 1997 and 2000, 180 patients underwent polydimethylsiloxane injection (74, 108 ureters) or extravesical ureteral reimplantation (106, 166 ureters) for low grade vesicoureteral reflux. Low grade reflux was defined as grades I to III. Outcome analysis included success rates, de novo hydronephrosis, voiding efficiency, urinary tract infections and complications. Results: Mean patient age at surgery for the injection and surgery groups was 60 and 77 months, and mean followup was 12 and 15 months, respectively. Of the patients who underwent single injection 80.6% were cured of reflux at 3 months and 91.6% were cured at last followup. Success rate after reimplantation was 95.8% at 3 months which improved to 98.8% 1 year later. The success rate was significantly different between the injection and reimplantation groups at 3 and 12 months (p <0.01). Postoperative complications in the reimplantation group included transient urinary retention after bilateral surgery in 2 patients (3.3%), suprapubic fluid collections in 2 and wound seroma in 1. No complications occurred in the polydimethylsiloxane group. Conclusions: Extravesical ureteral reimplantation has near perfect success with a low but definite complication rate. Polydimethylsiloxane offers high success rates for reflux in an ambulatory setting with no short-term complications. Currently, endoscopic polydimethylsiloxane injection is our preferred mode of therapy for low grade vesicoureteral reflux in children when surgical correction is indicated. References 1 : Pediatric Vesicoureteral Reflux Guidelines Panel summary report on the management of primary vesicoureteral reflux in children. J Urol1997; 157: 1846. Link, Google Scholar 2 : Extravesical nondismembered ureteroplasty with detrusorhaphy: a renewed technique to correct vesicoureteral reflux in children. J Urol1992; 148: 704. Link, Google Scholar 3 : Detrusorrhaphy: extravesical ureteral advancement to correct vesicoureteral reflux in children. J Urol1987; 138: 947. Link, Google Scholar 4 : Are postoperative studies justified after extravesical reimplantation?. J Urol2000; 164: 1064. Link, Google Scholar 5 : Multicenter survey of endoscopic treatment of vesicoureteral reflux using polytetrafluoroethylene. J Urol1998; 160: 1007. Link, Google Scholar 6 : Endoscopic injection of gluteraldehyde cross-linked bovine dermal collagen for correction of vesicoureteral reflux. J Urol1991; 145: 115. Link, Google Scholar 7 : Migration and granulomatous reaction after periurethral injection of polytef (Teflon). JAMA1984; 251: 3277. Crossref, Medline, Google Scholar 8 : Endoscopic substances for the treatment of vesicoureteral reflux. Urology1997; 50: 489. Crossref, Medline, Google Scholar 9 : Evaluation of polydimethylsiloxane as an alternative in the endoscopic treatment of vesicoureteral reflux. J Urol1994; 152: 1221. Link, Google Scholar 10 : Efficacy of endoscopic subureteral polydimethylsiloxane injection for treatment of vesicoureteral reflux in children: a North American clinical report. J Urol2001; 166: 1880. Link, Google Scholar 11 : Parental preferences in management of vesicoureteral reflux. J Urol2001; 166: 240. Link, Google Scholar 12 : Silicone implant rupture: detection with US. Radiology1993; 187: 761. Crossref, Medline, Google Scholar 13 : Contralateral reflux after unilateral ureteral reimplantation in patients with a history of resolved contralateral reflux. J Urol1995; 154: 1171. Link, Google Scholar 14 : Newly diagnosed contralateral reflux following successful unilateral endoscopic correction: is it due to a "pop off" mechanism?. J Urol1997; 158: 1213. Link, Google Scholar 15 : Voiding efficiency after ureteral reimplantation: comparison of extravesical and intravesical techniques. J Urol1995; 153: 1972. Link, Google Scholar 16 : The pelvic plexus and antireflux surgery: topographical findings and clinical consequences. J Urol2001; 165: 1652. Link, Google Scholar 17 : Infection pattern in children with vesicoureteral reflux randomly allocated to operation or long-term antibacterial prophylaxis. J Urol1992; 148: 1650. Link, Google Scholar 18 : Bladder symptoms and urinary infections. Nurs Times1991; 87: 55. Medline, Google Scholar 19 : Experience with vesicoureteral reflux in children: clinical characteristics. J Urol1997; 158: 574. Link, Google Scholar 20 : Dextranomer/hyaluronic acid copolymer implantation for vesicoureteral reflux: a randomized comparison with antibiotic prophylaxis. J Pediatr2002; 140: 230. Crossref, Medline, Google Scholar From the Division of Urology, The Hospital for Sick Children, Toronto, Ontario, Canada© 2003 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited by Aboutaleb H, Eldib D, Farahat Y, Abouelgreed T and Zanaty F (2022) Efficacy of Bladder Ultrasound in Prediction of Resolution of Vesicoureteral Reflux After Endoscopic Subureteral Hyaluronic Acid/Dextranomer (Deflux) InjectionUrology, 10.1016/j.urology.2022.01.015, VOL. 165, (299-304), Online publication date: 1-Jul-2022. Salih E, Eldamanhory H, Selmy G and Galal H (2021) Comparison of Subureteral Endoscopic Injection of Dextranomer/Hyaluronic Acid and Lich-Gregoir Ureteral Reimplantation in the Treatment of Pediatric Primary Vesicoureteral Reflux: A Prospective Randomized StudyJournal of Laparoendoscopic & Advanced Surgical Techniques, 10.1089/lap.2020.0973, VOL. 31, NO. 6, (719-723), Online publication date: 1-Jun-2021. Peters C (2020) History of Minimally Invasive and Robotic Assisted Surgery in Pediatric Urology Minimally Invasive and Robotic-Assisted Surgery in Pediatric Urology, 10.1007/978-3-030-57219-8_1, (3-18), . Choi J, Kim H, Ko Y, Lee Y and Song P (2016) Recurrent Urinary Tract Infection by Bladder Stone Resulting from Subureteral Injection Polydimethylsiloxane (Macroplastique®) for Treatment of Vesicoureteral RefluxUrogenital Tract Infection, 10.14777/uti.2016.11.2.62, VOL. 11, NO. 2, (62), . Van Batavia J, Nees S, Fast A, Combs A and Glassberg K (2014) Outcomes of vesicoureteral reflux in children with non-neurogenic lower urinary tract dysfunction treated with dextranomer/hyaluronic acid copolymer (Deflux)Journal of Pediatric Urology, 10.1016/j.jpurol.2013.10.017, VOL. 10, NO. 3, (482-487), Online publication date: 1-Jun-2014. Garcia-Aparicio L, Rovira J, Blazquez-Gomez E, García-García L, Giménez-Llort A, Rodo J and Morales L (2013) Randomized clinical trial comparing endoscopic treatment with dextranomer hyaluronic acid copolymer and Cohen's ureteral reimplantation for vesicoureteral reflux: Long-term resultsJournal of Pediatric Urology, 10.1016/j.jpurol.2013.03.003, VOL. 9, NO. 4, (483-487), Online publication date: 1-Aug-2013. Bush N (2012) Risk of Febrile Urinary Tract Infection After Reflux Surgery—Does the Type of Procedure Matter?Journal of Urology, VOL. 189, NO. 1, (14-15), Online publication date: 1-Jan-2013.Dwyer M, Husmann D, Rathbun S, Weight C and Kramer S (2012) Febrile Urinary Tract Infections After Ureteroneocystostomy and Subureteral Injection of Dextranomer/Hyaluronic Acid for Vesicoureteral Reflux—Do Choice of Procedure and Success Matter?Journal of Urology, VOL. 189, NO. 1, (275-282), Online publication date: 1-Jan-2013. Rowell A, Sangster G, Caraway J, Walker P, Elmajian D and Heldmann M (2012) Genitourinary Imaging: Part 1, Congenital Urinary Anomalies and Their ManagementAmerican Journal of Roentgenology, 10.2214/AJR.11.8197, VOL. 199, NO. 5, (W545-W553), Online publication date: 1-Nov-2012. Aubert D (2010) Traitement endoscopique du reflux vésico-urétéral par implant de polydiméthylsiloxane (Macroplastique™) : revue de la littératureProgrès en Urologie, 10.1016/j.purol.2009.10.017, VOL. 20, NO. 4, (251-259), Online publication date: 1-Apr-2010. Lacreuse I, Moog R, Kadoch V, Fischbach M, Poli Merol M and Becmeur F (2009) Autologous Adipocyte Graft in Endoscopic Treatment of Vesico-Renal Reflux in Children: A Preliminary StudyPediatric Reports, 10.4081/pr.2009.e7, VOL. 1, NO. 1, (e7) (2009) Bibliography Hinman's Atlas Of Pediatric Urologic Surgery, 10.1016/B978-0-7216-0645-3.00176-1, (873-923), . Ching C and Palmer J (2008) Surgical management of vesicoureteral refluxPediatric Health, 10.2217/17455111.2.2.205, VOL. 2, NO. 2, (205-216), Online publication date: 1-Apr-2008. Oh M, Kim H, Bae J, Park H, Kim J and Moon D (2008) Technical Considerations of Endoscopic Subureteral Injection for the Treatment of Vesicoureteral RefluxChonnam Medical Journal, 10.4068/cmj.2008.44.1.17, VOL. 44, NO. 1, (17), . Demède D, Cheikhelard A, Hoch M and Mouriquand P (2008) Médecine factuelle et reflux vésico-urétéralEMC - Urologie, 10.1016/S1762-0953(06)75019-1, VOL. 1, NO. 1, (1-11), Online publication date: 1-Jan-2008. Sung H, Park H and Park K (2007) Experience of Subureteral Polydimethylsiloxane Injection Treatment in Children with Vesicoureteral RefluxKorean Journal of Urology, 10.4111/kju.2007.48.1.82, VOL. 48, NO. 1, (82), . APPELL R, DMOCHOWSKI R and HERSCHORN S (2006) Urethral injections for female stress incontinenceBJU International, 10.1111/j.1464-410X.2006.06305.x, VOL. 98, NO. s1, (27-30), Online publication date: 1-Sep-2006. Demède D, Cheikhelard A, Hoch M and Mouriquand P (2006) Médecine factuelle et reflux vésico-urétéralAnnales d'Urologie, 10.1016/j.anuro.2006.02.005, VOL. 40, NO. 3, (161-174), Online publication date: 1-Jun-2006. Tsai C, Lin V and Tang L (2006) Injectable biomaterials for incontinence and vesico-ureteral reflux: Current status and future promiseJournal of Biomedical Materials Research Part B: Applied Biomaterials, 10.1002/jbm.b.30428, VOL. 77B, NO. 1, (171-178), Online publication date: 1-Apr-2006. Kim H, Shim K and Moon D (2006) The Early Experience and Technical Aspects of Endoscopic Subureteral Polydimethylsiloxane Injection for Vesicoureteral RefluxKorean Journal of Urology, 10.4111/kju.2006.47.2.154, VOL. 47, NO. 2, (154), . Demède D, Cheikhelard A, Hoch M and Mouriquand P (2006) Medicina basada en la evidencia y reflujo vesicoureteralEMC - Urología, 10.1016/S1761-3310(06)47119-X, VOL. 38, NO. 3, (1-12), Online publication date: 1-Jan-2006. Kim C and Docimo S Pediatric Endourology Advanced Endourology, 10.1007/978-1-59259-954-7_19, (323-349) Soto Beauregard C, Rivilla Parra F and García Casillas J (2005) Tratamiento endoscópico con polidimetilxilosano en el reflujo vesicoureteralAnales de Pediatría, 10.1157/13075547, VOL. 62, NO. 6, (543-547), Online publication date: 1-Jun-2005. Pilatz A, Schultheiss D, Gabouev A, Schlote N, Mertsching H, Jonas U and Stief C (2005) In vitro viability of human cavernosal endothelial and fibroblastic cells after exposure to papaverine/phentolamine and prostaglandin E1BJU International, 10.1111/j.1464-410X.2005.05499.x, VOL. 95, NO. 9, (1351-1357), Online publication date: 1-Jun-2005. de la Peña Zarzuelo E (2005) Tratamiento del reflujo vesico-ureteral primario en la infancia: comparación de dos revisiones sistemáticasActas Urológicas Españolas, 10.1016/S0210-4806(05)73217-4, VOL. 29, NO. 2, (138-162), Online publication date: 1-Jan-2005. van Capelle J, Haan T, Sayed W and Azmy A (2004) The long-term outcome of the endoscopic subureteric implantation of polydimethylsiloxane for treating vesico-ureteric reflux in children: a retrospective analysis of the first 195 consecutive patients in two European centresBJU International, 10.1111/j.1464-410X.2004.05172.x, VOL. 94, NO. 9, (1348-1351), Online publication date: 1-Dec-2004. Appell R (2004) Urethral and bladder injections for incontinence including botoxAtlas of the Urologic Clinics, 10.1016/j.auc.2004.06.005, VOL. 12, NO. 2, (159-164), Online publication date: 1-Oct-2004. Austin J and Cooper C (2004) Vesicoureteral reflux: surgical approachesUrologic Clinics of North America, 10.1016/j.ucl.2004.04.018, VOL. 31, NO. 3, (543-557), Online publication date: 1-Aug-2004. Stein R and Th??roff J (2004) Correction of vesicoureteral reflux: where do we stand?Current Opinion in Urology, 10.1097/01.mou.0000135076.19968.02, VOL. 14, NO. 4, (219-225), Online publication date: 1-Jul-2004. HALACHMI S, FARHAT W, METCALFE P, BAGLI D, McLORIE G and KHOURY A (2018) Efficacy of Polydimethylsiloxane Injection to the Bladder Neck and Leaking Diverting Stoma for Urinary ContinenceJournal of Urology, VOL. 171, NO. 3, (1287-1290), Online publication date: 1-Mar-2004. Schlussel R (2004) Cystoscopic correction of refluxCurrent Urology Reports, 10.1007/s11934-004-0025-7, VOL. 5, NO. 2, (127-131), Online publication date: 1-Mar-2004. Montorsi F, Briganti A, Salonia A, Rigatti P and Burnett A (2004) Current and future strategies for preventing and managing erectile dysfunction following radical prostatectomy Sildenafil, 10.1007/978-3-0348-7945-3_4, (49-65), . Dmochowski R and Appell R (2003) Advancements in minimally invasive treatments for female stress urinary incontinence: Radiofrequency and bulking agentsCurrent Urology Reports, 10.1007/s11934-003-0005-3, VOL. 4, NO. 5, (350-355), Online publication date: 1-Oct-2003. Volume 169Issue 1January 2003Page: 313-316 Advertisement Copyright & Permissions© 2003 by American Urological Association, Inc.Keywordsinjectionsdimethylpolysiloxanesureterreimplantationvesico-ureteral refluxMetrics Author Information HAMDY ABOUTALEB More articles by this author STÉPHANE BOLDUC More articles by this author JYOTI UPADHYAY More articles by this author WALID FARHAT More articles by this author DARIUS J. BÄGLI More articles by this author ANTOINE E. KHOURY More articles by this author Expand All Advertisement PDF downloadLoading ...

Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.