A69 ASSESSING COVID-19 VACCINATION COMPLIANCE AND HESITANCY IN THE EARLY ADULT (18-25YRS) INFLAMMATORY BOWEL DISEASE (IBD) POPULATION
Notice bibliographique
Résumé
Abstract Background Effective strategies at educating high risk IBD patients about COVID-19 and the benefits of vaccination is critical. Purpose The primary objective of this study was to assess the impact of early adulthood (18-25 years) on COVID-19 vaccination compliance. Secondary objectives were to assess the impact of early adulthood on vaccine hesitancy and reasons for non-compliance. Method A retrospective chart review was performed on all eligible IBD patients. Inclusion criteria: patients followed at Women’s College Hospital, age 18 years and older, diagnosis of Crohn’s disease (CD), Ulcerative Colitis (UC) or Indeterminant Colitis (IC). Data was collected between January 01 and August 31, 2022. Demographic data, level of immunosuppression and COVID-19 vaccine status were collected. All participants identified as not fully vaccinated (defined as less than 3 COVID-19 vaccines) were enrolled into the second phase of the study in which a modified Oxford COVID-19 Vaccine Hesitancy Scale was administered, and reasons for vaccine hesitancy discussed and addressed using a prepared educational template. Chi-square test evaluated the impact of age on vaccination status. Adjusted logistic regression was also performed. Fisher exact test evaluated the impact of age on willingness to accept vaccination counseling. Generalized linear regression model evaluated the impact of this on vaccine hesitancy. Result(s) 287 patients were included in the study of which 254 (89%) were immunosuppressed, 197 (69%) were female. 144 (50%) had CD, 136 (47%) had UC and 7 (2.4%) had IC. There were significantly more young adults who were under/unvaccinated 22/82 (27%) compared to older adults 22/205 (11%), p=0.0006 . Gender, IBD phenotype, immunosuppression status did not significantly affect vaccination status. The only variable found to significantly affect vaccination status on adjusted logistic regression was age, >25 years associated with OR 3.25 (95% CI 1.63-6.50) for full vaccination. 32/39 study subjects who were un/under-vaccinated agreed to counseling (82% of the early adults and 82% of older adults). Gender, IBD phenotype, immunesuppression status and age had no impact on uptake. Linear regression modeling found no significant impact on vaccine hesitancy by age, gender, IBD phenotype or immunesuppression. The main reasons described by patients for hesitancy included safety concerns and potential side effects (43%), perceived low risk (27%), prior COVID-19 infection (17%), lack of knowledge of current public health guidance (13%). Conclusion(s) Early adult IBD patients were found to be significantly less compliant with obtaining COVID-19 vaccines. This hesitancy mainly stems from concerns regarding vaccine safety and efficacy and perceived low risk. More targeted education strategies are required to increase awareness and ensure vaccine compliance. Please acknowledge all funding agencies by checking the applicable boxes below None Disclosure of Interest None Declared
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,004 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».