The Relationship of Circulating Extracellular Vesicles to Small Vessel Disease in Acute Ischemic Stroke
Notice bibliographique
Résumé
The association between Extracellular Vesicles (EVs) and Small Vessel Disease (SVD) might aid in the accurate early diagnosis and prognosis of acute ischemic stroke (AIS). This may be crucial for implementing the appropriate care plan and follow-up measures to limit the risk of permanent damage and prevent future occurrences. The purpose of the present study was to investigate the connection between circulating levels of EVs from various cellular origins and AIS severity biomarkers, established risk factors, and the presence of SVD as determined by noninvasive MRI imaging.The count of total circulating medium-size EVs and their phenotyping according to cellular origins were determined by flow cytometry analysis in platelet-free plasma from healthy volunteers and patients with AIS. Then, the relationship between the circulating of EVs to SVD and other risk factors was studied.When compared with controls, AIS patients exhibited a significantly higher number of circulating EVs originating from the endothelial cells, platelets, activated platelets, erythrocytes, and granulocytes. Multinomial logistic regression analysis showed a strong association between increased numbers of EVs derived from activated platelets (CD62P+) and erythrocytes (CD235a+) and the odds risk of AIS. However, it was found that a one-unit increase in CD235a+ EVs is associated with a 0.77-unit decrease in the odds of having SVD. Most AIS patients with SVD had hypertension, white matter ischemia, silent infarct, Basis Pontis ischemia, and cerebral microbleeds. However, the most significant risk for SVD was found in patients with hypertension on admission. Patients with hypertension on admission were 9.33 times more likely to have SVD than patients without hypertension on admission.Our findings underscore the value of circulating EVs as biomarkers of cell activation and thrombosis in AIS. Furthermore, our findings suggest a potential pathophysiological role for EVs in the onset and development of SVD and an interrelationship with major risk factors for AIS such as hypertension. Altogether, the association of EVs and non-invasive MRI imaging assessment of SVD presence may represent a novel combined approach for the identification of individuals with the highest risk of AIS and patients with the highest odds of recurrent stroke. This study was made possible by Qatar National Research Fund [grant No. NPRP11S-0114-180289]. The statements made herein are solely the responsibility of the authors. This is the full abstract presented at the American Physiology Summit 2023 meeting and is only available in HTML format. There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».